Imperial College London
Dr Kikkeri Naresh

DrKikkeriNaresh

Faculty of Medicine, Department of Immunology and Inflammation

Visiting Professor
 
 
 
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Contact

 

+44 (0)20 3313 3969k.naresh

 
 
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Location

 

Office 6, Building 541, G-BlockHammersmith HospitalHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Ponnusamy:2020:10.1101/2020.06.17.157107,
author = {Ponnusamy, K and Tzioni, MM and Begum, M and Robinson, ME and Caputo, VS and Katsarou, A and Trasanidis, N and Xiao, X and Kostopoulos, IV and Iskander, D and Roberts, I and Trivedi, P and Auner, HW and Naresh, K and Chaidos, A and Karadimitris, A},
doi = {10.1101/2020.06.17.157107},
title = {The innate sensor ZBP1-IRF3 axis regulates cell proliferation in multiple myeloma},
url = {http://dx.doi.org/10.1101/2020.06.17.157107},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - <jats:title>Abstract</jats:title><jats:p>ZBP1 is an inducible, non-constitutively expressed cellular nucleic acid sensor that triggers type I interferon (IFN) responses via phosphorylation and activation of the transcription factor (TF) IRF3 by TBK1. However, the role of the ZBP1-IRF3 axis in cancer is not known. Here we show that ZBP1 is selectively and constitutively expressed in late B cell development and it is required for optimal T cell-dependent humoral immune responses. In the plasma cell (PC) cancer multiple myeloma, interaction of constitutively expressed ZBP1 with TBK1 and IRF3 results in IRF3 phosphorylation. Notably, rather than IFN type I response genes, IRF3 directly activates, in part through co-operation with the PC lineage-defining TF IRF4, cell cycle genes thus promoting myeloma cell proliferation. This generates a novel, potentially therapeutically targetable and relatively selective myeloma cell addiction to the ZBP1-IRF3 axis. These data expand our knowledge of the role of cellular immune sensors in cancer biology.</jats:p>
AU  - Ponnusamy,K
AU  - Tzioni,MM
AU  - Begum,M
AU  - Robinson,ME
AU  - Caputo,VS
AU  - Katsarou,A
AU  - Trasanidis,N
AU  - Xiao,X
AU  - Kostopoulos,IV
AU  - Iskander,D
AU  - Roberts,I
AU  - Trivedi,P
AU  - Auner,HW
AU  - Naresh,K
AU  - Chaidos,A
AU  - Karadimitris,A
DO  - 10.1101/2020.06.17.157107
PY  - 2020///
TI  - The innate sensor ZBP1-IRF3 axis regulates cell proliferation in multiple myeloma
UR  - http://dx.doi.org/10.1101/2020.06.17.157107
ER  -
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