Imperial College London


Faculty of EngineeringDepartment of Electrical and Electronic Engineering

Visiting Professor



+44 (0)20 7594 1594k.nikolic




Bessemer 420CBessemer BuildingSouth Kensington Campus






BibTex format

author = {Mirza, K and Alenda, A and Eftekhar, A and Grossman, N and Nikolic, K and Bloom, S and Toumazou, C},
doi = {10.1142/S0129065718500065},
journal = {International Journal of Neural Systems},
title = {Influence of cholecystokinin-8 on compound nerve action potentials from ventral gastric vagus in rats},
url = {},
volume = {28},
year = {2018}

RIS format (EndNote, RefMan)

AB - Objective:Vagus Nerve Stimulation (VNS) has shown great promise as a potential therapy for anumber of conditions, such as epilepsy, depression and forNeurometabolic Therapies, especially fortreating obesity. The objective of this study was to characterise the left ventral subdiaphragmaticgastric trunk of vagus nerve (SubDiaGVN) and to analyse the influence of intravenous injection of guthormone cholecystokinin octapeptide (CCK-8) on compound nerve action potential (CNAP) observedon the same branch, with the aim of understanding the impact of hormones on VNS and incorporatingthe methods and results into closed loop implant design.Methods:The cervical region of the left vagus nerve (CerVN) of male Wistar rats was stimulatedwith electric current and the elicited CNAPs were recorded on the SubDiaGVN under four differentconditions:Control(no injection),Saline,CCK1(100 pmol/kg) andCCK2(1000 pmol/kg) injections.Results:We identified the presence of Aδ, B, C1, C2, C3 and C4 fibres with their respective velocityranges. Intravenous administration of CCKin vivoresults in selective, statistically significant reductionof CNAP components originating from A and B fibres, but with no discernible effect on the C fibresinn=7animals. The affected CNAP components exhibit statistically significant (pSaline−CCK1= 0.02andpSaline−CCK2= 0.007) higher normalized stimulation thresholds.Conclusion:This approach of characterising the vagus nerve can be used in closed loop systems todeterminewhento initiate VNS and also to tune the stimulation dose, which is patient specific andchanges over time.
AU - Mirza,K
AU - Alenda,A
AU - Eftekhar,A
AU - Grossman,N
AU - Nikolic,K
AU - Bloom,S
AU - Toumazou,C
DO - 10.1142/S0129065718500065
PY - 2018///
SN - 0129-0657
TI - Influence of cholecystokinin-8 on compound nerve action potentials from ventral gastric vagus in rats
T2 - International Journal of Neural Systems
UR -
UR -
VL - 28
ER -