Summary
Kieran obtained his PhD in malaria immunity from Imperial College London in 2001. He began research into acute inflammation and organ injury during sepsis at the Kennedy Institute for Rheumatology and then Chelsea Westminster Hospital, Imperial College Campus. He has published a broad range of articles related to sepsis and severe burns injury, particularly on the role of monocytes as orchestrators of acute lung injury. His research is currently focussed on the emerging roles of extracellular vesicles in critical care-related disease, investigating the intravascular trafficking of microvesicles and their contribution to acute lung injury.
He is a course organiser and lecturer in the intercalated medical Anaesthesia and Critical Care specialty BSc.
Publications
Journals
Tan YY, O'Dea KP, Tsiridou DM, et al., 2023, Circulating Myeloid Cell-derived Extracellular Vesicles as Mediators of Indirect Acute Lung Injury, American Journal of Respiratory Cell and Molecular Biology, Vol:68, ISSN:1044-1549, Pages:140-149
Tsiridou DM, Sachouli E, Takata M, et al., 2022, Neutrophil-Derived Microvesicles Enhance Pulmonary Vascular Inflammation via a Toll-like Receptor 4 Signaling-Dependent Mechanism., Faseb J, Vol:36 Suppl 1
Soni S, O'Dea K, Abe E, et al., 2022, Microvesicle-mediated communication within the alveolar space: mechanisms of uptake by epithelial cells and alveolar macrophages, Frontiers in Immunology, Vol:13, ISSN:1664-3224
Tan YY, O'Dea KP, Patel BV, et al., 2022, Investigation of microvesicle uptake by mouse lung-marginated monocytes in vitro., Bio-protocol, Vol:12, ISSN:2331-8325, Pages:1-1
Conference
Baldi RF, Soni S, Patel BV, et al., 2022, Macrophage-Derived Microvesicles Induce Alveolar Epithelial Cell Death in an In Vitro Stretch Model, International Conference of the American-Thoracic-Society, AMER THORACIC SOC, ISSN:1073-449X