Imperial College London


Faculty of Natural SciencesDepartment of Life Sciences

Senior Lecturer



+44 (0)20 7594 5742k.okuse Website




407Sir Ernst Chain BuildingSouth Kensington Campus





Research in our laboratory focuses on the molecular mechanism of pain pathways. We employ primary cultures of sensory neurons and macrophages, live cell imaging, and molecular biology.

1. Roles of neuropeptide VGF and its receptor in neuropathic pain.

2. Roles of macrophages in hyper-excitation of sensory neurons.

3. The mechanism of hypersensitisation of sensory neurons in chronic pain conditions.




Karu K, Swanwick RS, Novejarque-Gadea A, et al., 2020, Quantitative proteomic analysis of the central amygdala in neuropathic pain model rats, Journal of Proteome Research, Vol:19, ISSN:1535-3893, Pages:1592-1619

Soliman N, Okuse K, Rice A, 2019, VGF, a biomarker and potential target for the treatment of neuropathic pain?, Pain Reports, Vol:4, ISSN:2471-2531, Pages:1-14

Rizaner N, Onkal R, Fraser SP, et al., 2016, Intracellular calcium oscillations in strongly metastatic human breast and prostate cancer cells: control by voltage-gated sodium channel activity., European Biophysics Journal, Vol:45, ISSN:0175-7571, Pages:735-748

Moss PJ, Huang W, Dawes J, et al., 2015, Macrophage-sensory neuronal interaction in HIV-1 gp120-induced neurotoxicity, British Journal of Anaesthesia, Vol:114, ISSN:0007-0912, Pages:499-508


Okuse K, Ayub M, Swanwick R, et al., 2014, METHODS OF TREATING PAIN BY INHIBITION OF VGF ACTIVITY, WO2013110945

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