Imperial College London
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Dr Kris V Parag

Faculty of Medicine, School of Public Health

Research Fellow
 
 
 
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Contact

 

k.parag

 
 
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Location

 

Wright Fleming WingSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Buss:2021:10.1126/science.abe9728,
author = {Buss, LF and Prete, CA and Abrahim, CMM and Mendrone, A and Salomon, T and de, Almeida-Neto C and França, RFO and Belotti, MC and Carvalho, MPSS and Costa, AG and Crispim, MAE and Ferreira, SC and Fraiji, NA and Gurzenda, S and Whittaker, C and Kamaura, LT and Takecian, PL and da, Silva Peixoto P and Oikawa, MK and Nishiya, AS and Rocha, V and Salles, NA and de, Souza Santos AA and da, Silva MA and Custer, B and Parag, KV and Barral-Netto, M and Kraemer, MUG and Pereira, RHM and Pybus, OG and Busch, MP and Castro, MC and Dye, C and Nascimento, VH and Faria, NR and Sabino, EC},
doi = {10.1126/science.abe9728},
journal = {Science},
pages = {288--292},
title = {Three-quarters attack rate of SARS-CoV-2 in the Brazilian Amazon during a largely unmitigated epidemic.},
url = {http://dx.doi.org/10.1126/science.abe9728},
volume = {371},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spread rapidly in Manaus, the capital of Amazonas state in northern Brazil. The attack rate there is an estimate of the final size of the largely unmitigated epidemic that occurred in Manaus. We use a convenience sample of blood donors to show that by June 2020, 1 month after the epidemic peak in Manaus, 44% of the population had detectable immunoglobulin G (IgG) antibodies. Correcting for cases without a detectable antibody response and for antibody waning, we estimate a 66% attack rate in June, rising to 76% in October. This is higher than in São Paulo, in southeastern Brazil, where the estimated attack rate in October was 29%. These results confirm that when poorly controlled, COVID-19 can infect a large proportion of the population, causing high mortality.
AU  - Buss,LF
AU  - Prete,CA
AU  - Abrahim,CMM
AU  - Mendrone,A
AU  - Salomon,T
AU  - de,Almeida-Neto C
AU  - França,RFO
AU  - Belotti,MC
AU  - Carvalho,MPSS
AU  - Costa,AG
AU  - Crispim,MAE
AU  - Ferreira,SC
AU  - Fraiji,NA
AU  - Gurzenda,S
AU  - Whittaker,C
AU  - Kamaura,LT
AU  - Takecian,PL
AU  - da,Silva Peixoto P
AU  - Oikawa,MK
AU  - Nishiya,AS
AU  - Rocha,V
AU  - Salles,NA
AU  - de,Souza Santos AA
AU  - da,Silva MA
AU  - Custer,B
AU  - Parag,KV
AU  - Barral-Netto,M
AU  - Kraemer,MUG
AU  - Pereira,RHM
AU  - Pybus,OG
AU  - Busch,MP
AU  - Castro,MC
AU  - Dye,C
AU  - Nascimento,VH
AU  - Faria,NR
AU  - Sabino,EC
DO  - 10.1126/science.abe9728
EP  - 292
PY  - 2021///
SN  - 1095-9203
SP  - 288
TI  - Three-quarters attack rate of SARS-CoV-2 in the Brazilian Amazon during a largely unmitigated epidemic.
T2  - Science
UR  - http://dx.doi.org/10.1126/science.abe9728
UR  - https://www.ncbi.nlm.nih.gov/pubmed/33293339
UR  - https://science.sciencemag.org/content/early/2020/12/07/science.abe9728?versioned=true
VL  - 371
ER  -
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