Koralia Paschalaki is a Postdoctoral Clinical Research Fellow within the Airway Disease and Vascular Science sections of the National Heart and Lung Institute (NHLI), Imperial College London.
Dr Paschalaki qualified in Medicine from the University of Crete (Greece) and then completed specialist medical training in Respiratory Medicine in Athens. She joined Professor Peter J. Barnes' group in 2008. She also works in Dr Anna Randi’s group in the Vascular Science section of the NHLI.
Dr Paschalaki’s research interest is focused on the molecular mechanisms of endothelial dysfunction and vascular disease in smokers and patients with COPD, and uses endothelial progenitor cells as a tool to study vascular disease in patients. During her PhD, she found accelerated aging and increased DNA damage of endothelial progenitors in smoking groups due to epigenetic molecular dysfunction. These findings provide new insights into the molecular mechanisms involved in endothelial dysfunction in smokers and COPD patients, and are of great clinical importance as cardiovascular disease is a major cause of death in these groups. Her aim is to further investigate the mechanisms of endothelial progenitors dysfunction and vascular aging as contributors to atherosclerosis in smokers and COPD patients, and identify possible pharmacological treatments to target cardiovascular disease.
Paschalaki KE, Randi AM, 2018, Recent advances in endothelial colony forming cells toward their use in clinical translation, Frontiers in Medicine, Vol:5, ISSN:2296-858X
et al., 2017, Downregulation of MicroRNA-126 Augments DNA Damage Response in Cigarette Smokers and COPD Patients., Am J Respir Crit Care Med
et al., 2013, Dysfunction of endothelial progenitor cells from smokers and chronic obstructive pulmonary disease patients due to increased DNA damage and senescence, Stem Cells, Vol:31, ISSN:1066-5099, Pages:2813-2826
et al., 2013, Cellular and molecular basis of von Willebrand disease: studies on blood outgrowth endothelial cells, Blood, Vol:121, Pages:2773-2784
et al., 2011, Endothelial von Willebrand factor regulates angiogenesis, Blood, Vol:117, ISSN:0006-4971, Pages:1071-1080