Summary
I am a Senior Clinical Research Fellow in Vaccinology and Honorary Consultant at Imperial College London. I studied as an undergraduate in Medicine at Newnham College, University of Cambridge and Imperial College London, before qualifying as a junior doctor and undertaking specialist professional training in Genitourinary and HIV Medicine.
I am the clinical Principle Investigator across the diverse portfolio of vaccine studies at the Imperial NIHR Clinical Research Facility http://imperial.crf.nihr.ac.uk/. Working closely with Professor Robin Shattock in the Department of Infectious Disease, this work involves the crucial early-stage development of potential vaccines against pathogens such as HIV and chlamydia and includes first-in-man studies of potential vaccines. I also work closely with the Oxford Vaccine Group and Jenner Institute developing vaccines against diverse infections including ebola and malaria.
I hold a St. Mary’s Development Trust award for human vaccine research to investigate how T cells orchestrate the response to immunogens in the blood and secondary lymphoid tissue. This work is particularly important in helping us to design sophisticated vaccines that can induce the broadly neutralising antibody response required to protect against difficult targets such as HIV.
In 2019 I was awarded the Margaret Johnson prize by the British HIV Association for my work on influenza vaccine.
Publications
Journals
Tregoning JS, Brown ES, Cheeseman HM, et al., 2020, Vaccines for COVID-19, Clinical and Experimental Immunology, Vol:202, ISSN:0009-9104, Pages:162-192
Folegatti PM, Ewer KJ, Aley PK, et al., 2020, Safety and immunogenicity of the ChAdOx1 nCoV-19 vaccine against SARS-CoV-2: a preliminary report of a phase 1/2, single-blind, randomised controlled trial., The Lancet, Vol:396, ISSN:0140-6736, Pages:467-478
Saeed Z, Rowan A, Greiller C, et al., 2020, Enhanced T-cell maturation and monocyte aggregation are features of cellular inflammation in human T-lymphotropic virus type-1-associated myelopathy, Clinical Infectious Diseases, Vol:70, ISSN:1058-4838, Pages:1326-1335
Cole M, Saeed Z, Shaw A, et al., 2019, Responses to quadrivalent influenza vaccine reveal distinct circulating CD4+CXCR5+ T cell subsets in men living with HIV, Scientific Reports, Vol:9, ISSN:2045-2322
Francis-Morris A, Mackie NE, Eliahoo J, et al., 2019, Compromised CD4:CD8 ratio recovery in people living with HIV aged over 50 years: an observational study, Hiv Medicine, Vol:21, ISSN:1464-2662, Pages:109-118