Imperial College London
Alternate

DrKathleenSim

Faculty of Medicine, Department of Infectious Disease

Honorary Clinical Research Fellow
 
 
 
//

Contact

 

+44 (0)20 7594 3717k.sim

 
 
//

Location

 

125Wright Fleming WingSt Mary's Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Kroll:2020:10.1016/j.xcrm.2020.100077,
author = {Kroll, JS and Hall, L and Kiu, R and Shaw, A and Sim, K and Clarke, P and Dalby, MJ and Caim, S and Leclaire, C and Lawson, M and Ketskemety, J and Fardus-Reid, F and Chalken, L and Kujawska, M and Mitra, S and Belted, G and Swann, J and Alcon-Giner, C and McColl, K},
doi = {10.1016/j.xcrm.2020.100077},
journal = {Cell Reports Medicine},
title = {Microbiota supplementation with Bifidobacterium and Lactobacillus modifies the preterm infant gut microbiota and metabolome: an observational study},
url = {http://dx.doi.org/10.1016/j.xcrm.2020.100077},
volume = {1},
year = {2020}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Supplementation with members of the early-life microbiota as “probiotics” is increasingly used in attempts to beneficially manipulate the preterm infant gut microbiota. We performed a large observational longitudinal study comprising two preterm groups: 101 infants orally supplemented with Bifidobacterium and Lactobacillus (Bif/Lacto) and 133 infants non-supplemented (control) matched by age, sex, and delivery method. 16S rRNA gene profiling on fecal samples (n = 592) showed a predominance of Bifidobacterium and a lower abundance of pathobionts in the Bif/Lacto group. Metabolomic analysis showed higher fecal acetate and lactate and a lower fecal pH in the Bif/Lacto group compared to the control group. Fecal acetate positively correlated with relative abundance of Bifidobacterium, consistent with the ability of the supplemented Bifidobacterium strain to metabolize human milk oligosaccharides into acetate. This study demonstrates that microbiota supplementation is associated with a Bifidobacterium-dominated preterm microbiota and gastrointestinal environment more closely resembling that of full-term infants.
AU  - Kroll,JS
AU  - Hall,L
AU  - Kiu,R
AU  - Shaw,A
AU  - Sim,K
AU  - Clarke,P
AU  - Dalby,MJ
AU  - Caim,S
AU  - Leclaire,C
AU  - Lawson,M
AU  - Ketskemety,J
AU  - Fardus-Reid,F
AU  - Chalken,L
AU  - Kujawska,M
AU  - Mitra,S
AU  - Belted,G
AU  - Swann,J
AU  - Alcon-Giner,C
AU  - McColl,K
DO  - 10.1016/j.xcrm.2020.100077
PY  - 2020///
SN  - 2666-3791
TI  - Microbiota supplementation with Bifidobacterium and Lactobacillus modifies the preterm infant gut microbiota and metabolome: an observational study
T2  - Cell Reports Medicine
UR  - http://dx.doi.org/10.1016/j.xcrm.2020.100077
UR  - http://hdl.handle.net/10044/1/82162
VL  - 1
ER  -
Download