Imperial College London
Alternate

DrKostasTsilidis

Faculty of Medicine, School of Public Health

Reader in Cancer Epidemiology and Prevention
 
 
 
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Contact

 

+44 (0)20 7594 2623k.tsilidis

 
 
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Location

 

School of Public HealthWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Christakoudi:2021:10.1038/s41598-021-89176-6,
author = {Christakoudi, S and Evangelou, E and Riboli, E and Tsilidis, K},
doi = {10.1038/s41598-021-89176-6},
journal = {Scientific Reports},
pages = {1--18},
title = {GWAS of allometric body-shape indices in UK Biobank identifies loci suggesting associations with morphogenesis, organogenesis, adrenal cell renewal and cancer},
url = {http://dx.doi.org/10.1038/s41598-021-89176-6},
volume = {11},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Genetic studies have examined body-shape measures adjusted for body mass index (BMI), while allometric indices are additionally adjusted for height. We performed the first genome-wide association study of A Body Shape Index (ABSI), Hip Index (HI) and the new Waist-to-Hip Index and compared these with traditional indices, using data from the UK Biobank Resource for 219,872 women and 186,825 men with white British ancestry and Bayesian linear mixed-models (BOLT-LMM). One to two thirds of the loci identified for allometric body-shape indices were novel. Most prominent was rs72959041 variant in RSPO3 gene, expressed in visceral adipose tissue and regulating adrenal cell renewal. Highly ranked were genes related to morphogenesis and organogenesis, previously additionally linked to cancer development and progression. Genetic associations were fewer in men compared to women. Prominent region-specific associations showed variants in loci VEGFA and HMGA1 for ABSI and KLF14 for HI in women, and C5orf67 and HOXC4/5 for ABSI and RSPO3, VEGFA and SLC30A10 for HI in men. Although more variants were associated with waist and hip circumference adjusted for BMI compared to ABSI and HI, associations with height had previously been reported for many of the additional variants, illustrating the importance of adjusting correctly for height.
AU  - Christakoudi,S
AU  - Evangelou,E
AU  - Riboli,E
AU  - Tsilidis,K
DO  - 10.1038/s41598-021-89176-6
EP  - 18
PY  - 2021///
SN  - 2045-2322
SP  - 1
TI  - GWAS of allometric body-shape indices in UK Biobank identifies loci suggesting associations with morphogenesis, organogenesis, adrenal cell renewal and cancer
T2  - Scientific Reports
UR  - http://dx.doi.org/10.1038/s41598-021-89176-6
UR  - https://www.nature.com/articles/s41598-021-89176-6
UR  - http://hdl.handle.net/10044/1/89403
VL  - 11
ER  -
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