Imperial College London
Alternate

DrKostasTsilidis

Faculty of Medicine, School of Public Health

Reader in Cancer Epidemiology and Prevention
 
 
 
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Contact

 

+44 (0)20 7594 2623k.tsilidis

 
 
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Location

 

Praed StreetSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Bouras:2021:10.1007/s12672-021-00402-z,
author = {Bouras, E and Papandreou, C and Tzoulaki, I and Tsilidis, K},
doi = {10.1007/s12672-021-00402-z},
journal = {Discover Oncology},
pages = {1--1},
title = {Endogenous sex steroid hormones and colorectal cancer risk: a systematic review and meta-analysis},
url = {http://dx.doi.org/10.1007/s12672-021-00402-z},
volume = {12},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Preclinical data suggest that endogenous sex steroid hormones may be implicated in colorectal cancer (CRC) development, however, findings from epidemiological studies are conflicting. The aim of this systematic review and meta-analysis was to investigate the associations between endogenous concentrations of sex hormones and CRC risk. PubMed and Scopus were searched until June 2020 for prospective studies evaluating the association between pre-diagnostic plasma/serum concentrations of estradiol, testosterone and sex-hormone binding globulin (SHBG) and CRC risk. Summary relative risks (RRs) and 95% confidence intervals (CIs) were estimated using the inverse-variance weighted random-effects model based on the DerSimonian-Laird estimator. Eight studies were included in the meta-analysis after evaluating 3,859 non-duplicate records. Four of the eight studies had a nested case–control design, one study was a case-cohort and the rest three studies were cohort studies, and they included on average 295 cases (range:48–732) and 2,105 controls. No associations were found for endogenous sex steroid hormones in men or post-menopausal women with CRC risk, with evidence for substantial heterogeneity observed among women. Findings from this meta-analysis do not support presence of associations between pre-diagnostic concentrations of testosterone, estradiol and SHBG with incident CRC risk in men and post-menopausal women.
AU  - Bouras,E
AU  - Papandreou,C
AU  - Tzoulaki,I
AU  - Tsilidis,K
DO  - 10.1007/s12672-021-00402-z
EP  - 1
PY  - 2021///
SN  - 2730-6011
SP  - 1
TI  - Endogenous sex steroid hormones and colorectal cancer risk: a systematic review and meta-analysis
T2  - Discover Oncology
UR  - http://dx.doi.org/10.1007/s12672-021-00402-z
UR  - https://link.springer.com/article/10.1007/s12672-021-00402-z
UR  - http://hdl.handle.net/10044/1/88425
VL  - 12
ER  -
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