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@article{Tsilidis:2021:ajcn/nqab003,
author = {Tsilidis, KK and Papadimitriou, N and Dimou, N and Gill, D and Lewis, SJ and Martin, RM and Murphy, N and Markozannes, G and Zuber, V and Cross, AJ and Burrows, K and Lopez, DS and Key, TJ and Travis, RC and Perez-Cornago, A and Hunter, DJ and van, Duijnhoven FJB and Albanes, D and Arndt, V and Berndt, SI and Bézieau, S and Bishop, DT and Boehm, J and Brenner, H and Burnett-Hartman, A and Campbell, PT and Casey, G and Castellví-Bel, S and Chan, AT and Chang-Claude, J and de, la Chapelle A and Figueiredo, JC and Gallinger, SJ and Giles, GG and Goodman, PJ and Gsur, A and Hampe, J and Hampel, H and Hoffmeister, M and Jenkins, MA and Keku, TO and Kweon, S-S and Larsson, SC and Le, Marchand L and Li, CI and Li, L and Lindblom, A and Martín, V and Milne, RL and Moreno, V and Nan, H and Nassir, R and Newcomb, PA and Offit, K and Pharoah, PDP and Platz, EA and Potter, JD and Qi, L and Rennert, G and Sakoda, LC and Schafmayer, C and Slattery, ML and Snetselaar, L and Schenk, J and Thibodeau, S},
doi = {ajcn/nqab003},
journal = {American Journal of Clinical Nutrition},
pages = {1490--1502},
title = {Genetically predicted circulating concentrations of micronutrients and risk of colorectal cancer among individuals of European descent: a Mendelian randomization study},
url = {http://dx.doi.org/10.1093/ajcn/nqab003},
volume = {113},
year = {2021}
}

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TY  - JOUR
AB  - BACKGROUND: The literature on associations of circulating concentrations of minerals and vitamins with risk of colorectal cancer is limited and inconsistent. Evidence from randomized controlled trials (RCTs) to support the efficacy of dietary modification or nutrient supplementation for colorectal cancer prevention is also limited. OBJECTIVES: To complement observational and RCT findings, we investigated associations of genetically predicted concentrations of 11 micronutrients (β-carotene, calcium, copper, folate, iron, magnesium, phosphorus, selenium, vitamin B-6, vitamin B-12, and zinc) with colorectal cancer risk using Mendelian randomization (MR). METHODS: Two-sample MR was conducted using 58,221 individuals with colorectal cancer and 67,694 controls from the Genetics and Epidemiology of Colorectal Cancer Consortium, Colorectal Cancer Transdisciplinary Study, and Colon Cancer Family Registry. Inverse variance-weighted MR analyses were performed with sensitivity analyses to assess the impact of potential violations of MR assumptions. RESULTS: Nominally significant associations were noted for genetically predicted iron concentration and higher risk of colon cancer [ORs per SD (ORSD): 1.08; 95% CI: 1.00, 1.17; P value = 0.05] and similarly for proximal colon cancer, and for vitamin B-12 concentration and higher risk of colorectal cancer (ORSD: 1.12; 95% CI: 1.03, 1.21; P value = 0.01) and similarly for colon cancer. A nominally significant association was also noted for genetically predicted selenium concentration and lower risk of colon cancer (ORSD: 0.98; 95% CI: 0.96, 1.00; P value = 0.05) and similarly for distal colon cancer. These associations were robust to sensitivity analyses. Nominally significant inverse associations were observed for zinc and risk of colorectal and distal colon cancers, but sensitivity analyses could not be performed. None of these findings survived correction for multiple testing. Genetica
AU  - Tsilidis,KK
AU  - Papadimitriou,N
AU  - Dimou,N
AU  - Gill,D
AU  - Lewis,SJ
AU  - Martin,RM
AU  - Murphy,N
AU  - Markozannes,G
AU  - Zuber,V
AU  - Cross,AJ
AU  - Burrows,K
AU  - Lopez,DS
AU  - Key,TJ
AU  - Travis,RC
AU  - Perez-Cornago,A
AU  - Hunter,DJ
AU  - van,Duijnhoven FJB
AU  - Albanes,D
AU  - Arndt,V
AU  - Berndt,SI
AU  - Bézieau,S
AU  - Bishop,DT
AU  - Boehm,J
AU  - Brenner,H
AU  - Burnett-Hartman,A
AU  - Campbell,PT
AU  - Casey,G
AU  - Castellví-Bel,S
AU  - Chan,AT
AU  - Chang-Claude,J
AU  - de,la Chapelle A
AU  - Figueiredo,JC
AU  - Gallinger,SJ
AU  - Giles,GG
AU  - Goodman,PJ
AU  - Gsur,A
AU  - Hampe,J
AU  - Hampel,H
AU  - Hoffmeister,M
AU  - Jenkins,MA
AU  - Keku,TO
AU  - Kweon,S-S
AU  - Larsson,SC
AU  - Le,Marchand L
AU  - Li,CI
AU  - Li,L
AU  - Lindblom,A
AU  - Martín,V
AU  - Milne,RL
AU  - Moreno,V
AU  - Nan,H
AU  - Nassir,R
AU  - Newcomb,PA
AU  - Offit,K
AU  - Pharoah,PDP
AU  - Platz,EA
AU  - Potter,JD
AU  - Qi,L
AU  - Rennert,G
AU  - Sakoda,LC
AU  - Schafmayer,C
AU  - Slattery,ML
AU  - Snetselaar,L
AU  - Schenk,J
AU  - Thibodeau,SN
AU  - Ulrich,CM
AU  - Van,Guelpen B
AU  - Harlid,S
AU  - Visvanathan,K
AU  - Vodickova,L
AU  - Wang,H
AU  - White,E
AU  - Wolk,A
AU  - Woods,MO
AU  - Wu,AH
AU  - Zheng,W
AU  - Bueno-de-Mesquita,B
AU  - Boutron-Ruault,M-C
AU  - Hughes,DJ
AU  - Jakszyn,P
AU  - Kühn,T
AU  - Palli,D
AU  - Riboli,E
AU  - Giovannucci,EL
AU  - Banbury,BL
AU  - Gruber,SB
AU  - Peters,U
AU  - Gunter,MJ
DO  - ajcn/nqab003
EP  - 1502
PY  - 2021///
SN  - 0002-9165
SP  - 1490
TI  - Genetically predicted circulating concentrations of micronutrients and risk of colorectal cancer among individuals of European descent: a Mendelian randomization study
T2  - American Journal of Clinical Nutrition
UR  - http://dx.doi.org/10.1093/ajcn/nqab003
UR  - https://www.ncbi.nlm.nih.gov/pubmed/33740060
UR  - http://hdl.handle.net/10044/1/87146
VL  - 113
ER  -

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