Imperial College London
Alternate

DrKostasTsilidis

Faculty of Medicine, School of Public Health

Reader in Cancer Epidemiology and Prevention
 
 
 
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Contact

 

+44 (0)20 7594 2623k.tsilidis

 
 
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Location

 

School of Public HealthWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Lopez:2021:10.1007/s10552-021-01450-0,
author = {Lopez, DS and Huang, D and Tsilidis, KK and Canfield, S and Khera, M and Baillargeon, JG and Kuo, Y-F and Peek, MK and Platz, EA and Markides, K},
doi = {10.1007/s10552-021-01450-0},
journal = {Cancer Causes and Control},
pages = {965--976},
title = {The role of testosterone replacement therapy and statin use, and their combination, in prostate cancer},
url = {http://dx.doi.org/10.1007/s10552-021-01450-0},
volume = {32},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Purpose:Previous studies have reported conflicting results in the associations of testosterone replacement therapy (TTh) and statins use with prostate cancer (PCa). However, the combination of these treatments with PCa stage and grade at diagnosis and prostate cancer-specific mortality (PCSM) and by race/ethnicity remains unclear.Methods:We identified non-Hispanic White (NHW, N = 58,576), non-Hispanic Black (NHB, n = 9,703) and Hispanic (n = 4,898) men diagnosed with PCa in SEER-Medicare data 2007–2011. Pre-diagnostic prescription of TTh and statins was ascertained for this analysis. Multivariable-adjusted logistic and Cox proportional hazards models were used to evaluate the association of TTh and statins use with PCa stage and grade and PCSM.Results:22.5% used statins alone, 1.2% used TTh alone, and 0.8% used both. TTh and statins were independently, inversely associated with PCa advanced stage and high grade. TTh plus statins was associated with 44% lower odds of advanced stage PCa (OR 0.56, 95% CI 0.35–0.91). As expected, similar inverse associations were present in NHWs as the overall cohort is mostly comprised NHW men. In Hispanic men, statin use with or without TTh was inversely associated with aggressive PCa.Conclusions:Pre-diagnostic use of TTh or statins, independent or in combination, was inversely associated with aggressive PCa, including in NHW and Hispanics men, but was not with PCSM. The findings for use of statins with aggressive PCa are consistent with cohort studies. Future prospective studies are needed to explore the independent inverse association of TTh and the combined inverse association of TTh plus statins on fatal PCa.
AU  - Lopez,DS
AU  - Huang,D
AU  - Tsilidis,KK
AU  - Canfield,S
AU  - Khera,M
AU  - Baillargeon,JG
AU  - Kuo,Y-F
AU  - Peek,MK
AU  - Platz,EA
AU  - Markides,K
DO  - 10.1007/s10552-021-01450-0
EP  - 976
PY  - 2021///
SN  - 0957-5243
SP  - 965
TI  - The role of testosterone replacement therapy and statin use, and their combination, in prostate cancer
T2  - Cancer Causes and Control
UR  - http://dx.doi.org/10.1007/s10552-021-01450-0
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000654816700002&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://link.springer.com/article/10.1007%2Fs10552-021-01450-0
UR  - http://hdl.handle.net/10044/1/89954
VL  - 32
ER  -
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