Publications

BibTex format

@article{Huang:2023:10.1212/WNL.0000000000201489,
author = {Huang, J and Su, B and Karhunen, V and Gill, D and Zuber, V and Ahola-Olli, A and Palaniswamy, S and Auvinen, J and Herzig, K-H and Keinänen-Kiukaanniemi, S and Salmi, M and Jalkanen, S and Lehtimäki, T and Salomaa, V and Raitakari, OT and Matthews, PM and Elliott, P and Tsilidis, KK and Jarvelin, M-R and Tzoulaki, I and Dehghan, A},
doi = {10.1212/WNL.0000000000201489},
journal = {Neurology},
pages = {e568--e581},
title = {Inflammatory diseases, inflammatory biomarkers, and Alzheimer disease: an observational analysis and mendelian randomization},
url = {http://dx.doi.org/10.1212/WNL.0000000000201489},
volume = {100},
year = {2023}
}

Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - OBJECTIVES: Whether chronic autoimmune inflammatory diseases causally affect the risk of AD is controversial. We characterised the relationship between inflammatory diseases and the risk of AD and explore the role of circulating inflammatory biomarkers in the relationships between inflammatory diseases and AD. METHODS: We performed observational analyses for chronic autoimmune inflammatory diseases and risk of AD using data from 2,047,513 participants identified in the UK Clinical Practice Research Datalink (CPRD). Using data of a total of more than 1,100,000 individuals from 15 large scale genome-wide association study (GWAS) datasets, we performed two-sample Mendelian randomisation (MR) to investigate the relationships between chronic autoimmune inflammatory diseases, circulating inflammatory biomarker levels, and risk of AD. RESULTS: Cox regression models using CPRD data showed that overall incidence of AD was higher among patients with inflammatory bowel disease (IBD) (hazard ratio (HR)=1.17; 95%CI 1.15 to 1.19; P-value=2.1×10-4), other inflammatory polyarthropathies & systematic connective tissue disorders (OID) (HR=1.13; 95%CI 1.12 to 1.14; P-value=8.6×10-5), psoriasis (HR=1.13; 95%CI 1.10 to 1.16; P-value=2.6×10-4), rheumatoid arthritis (RA) (HR=1.08; 95%CI 1.06 to 1.11; P-value=4.0×10-4), and multiple sclerosis (MS) (HR=1.06; 95%CI 1.04 to 1.07; P-value=2.8×10-4) compared to the age (± 5 years) and sex-matched comparison groups free from all inflammatory diseases under investigation. Bidirectional MR analysis identified relationships between chronic autoimmune inflammatory diseases and circulating inflammatory biomarkers. Particularly, circulating monokine induced by gamma interferon (MIG) level was suggestively associated with a higher risk of AD (odds ratio from inverse variance weighted (ORIVW)=1.23; 95%CI 1.06 to 1.42; PIVW=0.007), and lower risk of Crohn's disease (ORIVW=0.73; 95%CI -0.62, 0.86; PIVW=1.3×10
AU  - Huang,J
AU  - Su,B
AU  - Karhunen,V
AU  - Gill,D
AU  - Zuber,V
AU  - Ahola-Olli,A
AU  - Palaniswamy,S
AU  - Auvinen,J
AU  - Herzig,K-H
AU  - Keinänen-Kiukaanniemi,S
AU  - Salmi,M
AU  - Jalkanen,S
AU  - Lehtimäki,T
AU  - Salomaa,V
AU  - Raitakari,OT
AU  - Matthews,PM
AU  - Elliott,P
AU  - Tsilidis,KK
AU  - Jarvelin,M-R
AU  - Tzoulaki,I
AU  - Dehghan,A
DO  - 10.1212/WNL.0000000000201489
EP  - 581
PY  - 2023///
SN  - 0028-3878
SP  - 568
TI  - Inflammatory diseases, inflammatory biomarkers, and Alzheimer disease: an observational analysis and mendelian randomization
T2  - Neurology
UR  - http://dx.doi.org/10.1212/WNL.0000000000201489
UR  - https://www.ncbi.nlm.nih.gov/pubmed/36384659
UR  - https://n.neurology.org/content/100/6/e568
UR  - http://hdl.handle.net/10044/1/100578
VL  - 100
ER  -

Download

DrKostasTsilidis

Contact

Location

Summary

Citation

BibTex format

RIS format (EndNote, RefMan)