Imperial College London
Portrait Picture

Dr Kenny Weir

Faculty of Natural Sciences, Department of Physics

Reader in Photonics
 
 
 
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Contact

 

+44 (0)20 7594 7501k.weir

 
 
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Location

 

636BBlackett LaboratorySouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Amrania:2016:10.1039/c5fd00150a,
author = {Amrania, H and Drummond, L and Coombes, RC and Shousha, S and Woodley-Barker, L and Weir, K and Hart, W and Carter, I and Phillips, CC},
doi = {10.1039/c5fd00150a},
journal = {Faraday Discussions},
pages = {539--553},
title = {New IR imaging modalities for cancer detection and for intra-cell chemical mapping with a sub-diffraction mid-IR s-SNOM},
url = {http://dx.doi.org/10.1039/c5fd00150a},
volume = {187},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - We present two new modalities for generating chemical maps. Both are mid-IR based and aimed at the biomedical community, but they differ substantially in their technological readiness. The first, so-called "Digistain", is a technologically mature "locked down" way of acquiring diffraction-limited chemical images of human cancer biopsy tissue. Although it is less flexible than conventional methods of acquiring IR images, this is an intentional, and key, design feature. It allows it to be used, on a routine basis, by clinical personnel themselves. It is in the process of a full clinical evaluation and the philosophy behind the approach is discussed. The second modality is a very new, probe-based "s-SNOM", which we are developing in conjunction with a new family of tunable "Quantum Cascade Laser" (QCL) diode lasers. Although in its infancy, this instrument can already deliver ultra-detailed chemical images whose spatial resolutions beat the normal diffraction limit by a factor of ∼1000. This is easily enough to generate chemical maps of the insides of single cells for the first time, and a range of new possible scientific applications are explored.
AU  - Amrania,H
AU  - Drummond,L
AU  - Coombes,RC
AU  - Shousha,S
AU  - Woodley-Barker,L
AU  - Weir,K
AU  - Hart,W
AU  - Carter,I
AU  - Phillips,CC
DO  - 10.1039/c5fd00150a
EP  - 553
PY  - 2016///
SN  - 1364-5498
SP  - 539
TI  - New IR imaging modalities for cancer detection and for intra-cell chemical mapping with a sub-diffraction mid-IR s-SNOM
T2  - Faraday Discussions
UR  - http://dx.doi.org/10.1039/c5fd00150a
UR  - http://hdl.handle.net/10044/1/34599
VL  - 187
ER  -
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