Imperial College London
Portrait Picture

Dr Kevin Woollard

Faculty of Medicine, Department of Immunology and Inflammation

Honorary Senior Lecturer
 
 
 
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Contact

 

+44 (0)20 3313 2357k.woollard Website

 
 
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Location

 

9N15CCommonwealth BuildingHammersmith Campus

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Summary

 

Publications

Publication Type
Year
to

137 results found

Rahman M, Frost G, Scott JF, Haskard DO, Woollard KJet al., 2015, CHARACTERISING HUMAN MONOCYTE SUBSETS AS LIPID VEHICLES FOLLOWING DIETARY STIMULI, 83rd Congress of the European-Atherosclerosis-Society (EAS), Publisher: ELSEVIER IRELAND LTD, Pages: E81-E81, ISSN: 0021-9150

Conference paper

Jackson WD, Weinrich TW, Woollard KJ, 2015, ATHEROGENIC DYSLIPIDEMIA MODULATES MONOCYTE SUBPOPULATION MIGRATION VIA RHOA, 83rd Congress of the European-Atherosclerosis-Society (EAS), Publisher: ELSEVIER IRELAND LTD, Pages: E10-E10, ISSN: 0021-9150

Conference paper

Tarzi RM, Liu J, Schneiter S, Hill NR, Page TH, Cook HT, Pusey CD, Woollard KJet al., 2015, CD14 expression is increased on monocytes in patients with anti-neutrophil cytoplasm antibody (ANCA)-associated vasculitis and correlates with the expression of ANCA autoantigens, CLINICAL AND EXPERIMENTAL IMMUNOLOGY, Vol: 181, Pages: 65-75, ISSN: 0009-9104

Journal article

Iqbal MB, Johns M, Cao J, Liu Y, Yu S-C, Hyde GD, Laffan MA, Marchese FP, Cho SH, Clark AR, Gavins FN, Woollard KJ, Blackshear PJ, Mackman N, Dean JL, Boothby M, Haskard DOet al., 2014, PARP-14 combines with tristetraprolin in the selective posttranscriptional control of macrophage tissue factor expression, Blood, Vol: 124, Pages: 3646-3655, ISSN: 0006-4971

Tissue factor (TF) (CD142) is a 47 kDa transmembrane cell surface glycoprotein that triggers the extrinsic coagulation cascade and links thrombosis with inflammation. Although macrophage TF expression is known to be regulated at the RNA level, very little is known about the mechanisms involved. Poly(adenosine 5′-diphosphate [ADP]-ribose)-polymerase (PARP)-14 belongs to a family of intracellular proteins that generate ADP-ribose posttranslational adducts. Functional screening of PARP-14–deficient macrophages mice revealed that PARP-14 deficiency leads to increased TF expression and functional activity in macrophages after challenge with bacterial lipopolysaccharide. This was related to an increase in TF messenger RNA (mRNA) stability. Ribonucleoprotein complex immunoprecipitation and biotinylated RNA pull-down assays demonstrated that PARP-14 forms a complex with the mRNA-destabilizing protein tristetraprolin (TTP) and a conserved adenylate-uridylate-rich element in the TF mRNA 3′ untranslated region. TF mRNA regulation by PARP-14 was selective, as tumor necrosis factor (TNF)α mRNA, which is also regulated by TTP, was not altered in PARP-14 deficient macrophages. Consistent with the in vitro data, TF expression and TF activity, but not TNFα expression, were increased in Parp14−/− mice in vivo. Our study provides a novel mechanism for the posttranscriptional regulation of TF expression, indicating that this is selectively regulated by PARP-14.

Journal article

Khamis R, Woollard K, Kojima C, Boyle J, Shah P, Chang S-H, Hyde G, Johns M, Haskard Det al., 2014, A novel immunoglobulin G autoantibody against a cryptic epitope in low density lipoprotein (LDL) revealed in atherosclerosis

Poster

Khamis R, Woollard K, Boyle JJ, Chang S-H, Hyde G, Johns M, Haskard Det al., 2014, A Novel Immunoglobulin G Autoantibody Against a Cryptic Epitope in Low Density Lipoprotein Induces Macrophage Tumour Necrosis Factor Release, Publisher: LIPPINCOTT WILLIAMS & WILKINS, ISSN: 0009-7322

Conference paper

Dufton N, Kemp J, Woollard K, Osuna-Almagro L, Yang Y, Birdsey G, Randi Aet al., 2014, Transcriptional regulation of the endothelial SDF-1/CXCR4/CXCR7 pathway by ERG plays a key role in the mobilization and transmigration of leukocytes during vascular inflammation, Publisher: SPRINGER, Pages: 966-967, ISSN: 0969-6970

Conference paper

Rogacev KS, Zawada AM, Emrich I, Seiler S, Boehm M, Fliser D, Woollard KJ, Heine GHet al., 2014, Lower Apo A-I and Lower HDL-C Levels Are Associated With Higher Intermediate CD14<SUP>++</SUP>CD16<SUP>+</SUP> Monocyte Counts That Predict Cardiovascular Events in Chronic Kidney Disease, ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, Vol: 34, Pages: 2120-2127, ISSN: 1079-5642

Journal article

Thiele JR, Habersberger J, Braig D, Schmidt Y, Goerendt K, Maurer V, Bannasch H, Scheichl A, Woollard KJ, von Dobschuetz E, Kolodgie F, Virmani R, Stark GB, Peter K, Eisenhardt SUet al., 2014, Dissociation of Pentameric to Monomeric C-Reactive Protein Localizes and Aggravates Inflammation In Vivo Proof of a Powerful Proinflammatory Mechanism and a New Anti-Inflammatory Strategy, CIRCULATION, Vol: 130, Pages: 35-+, ISSN: 0009-7322

Journal article

Jackson WD, Woollard KJ, 2014, Targeting monocyte and macrophage subpopulations for immunotherapy: a patent review (2009-2013), EXPERT OPINION ON THERAPEUTIC PATENTS, Vol: 24, Pages: 779-790, ISSN: 1354-3776

Journal article

Lumsden NGA, Woollard KJ, Andrews KA, Aprico A, Irvine JC, Jefferis AM, Fang KL, Kanellakis P, Bobik A, Chin-Dusting JFPet al., 2014, RAISED SOLUBLE P-SELECTIN MODULATES PLAQUE INSTABILITY IN AN EXPERIMENTAL MODEL OF VULNERABLE PLAQUE, 35th Annual Scientific Meeting of the High-Blood-Pressure-Research-Council-of-Australia (HBPRCA) / 39th Annual Scientific Meeting of the Australian-Atherosclerosis-Society (AAS), Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: E153-E153, ISSN: 0194-911X

Conference paper

Khamis R, Woollard K, Boyle J, Chang S-H, Hyde G, Johns M, Haskard Det al., 2014, A NOVEL IMMUNOGLOBULIN G AUTOANTIBODY AGAINST LOW DENSITY LIPOPROTEIN (LDL) WITH PATHOGENIC FUNCTIONS, Annual Conference of the British-Cardiovascular-Society, Publisher: BMJ PUBLISHING GROUP, Pages: A121-A121, ISSN: 1355-6037

Conference paper

Khamis RY, Woollard KJ, Hyde GD, Boyle JJ, Bicknell C, Hara T, Mauskapf A, Granger DW, Johnson JL, Ntziachristos V, Matthews PM, Jaffer FA, Haskard DOet al., 2014, DEVELOPMENT OF WHOLE BODY AND INTRAVASCULAR NEAR-INFRARED OPTICAL MOLECULAR IMAGING OF MARKERS OF PLAQUE VULNERABLITY IN ATHEROSCLEROSIS, Annual Conference of the British-Cardiovascular-Society

Poster

Woollard KJ, Lumsden NG, Andrews KL, Aprico A, Harris E, Irvine JC, Jefferis A-M, Fang L, Kanellakis P, Bobik A, Chin-Dusting JPFet al., 2014, Raised Soluble P-Selectin Moderately Accelerates Atherosclerotic Plaque Progression, PLOS ONE, Vol: 9, ISSN: 1932-6203

Journal article

Rogacev K, Zawada A, Emrich I, Seiler S, Boehm M, Fliser D, Woollard K, Heine Get al., 2014, INTERMEDIATE MONOCYTE COUNTS ARE DETERMINED BY SURROGATES OF CHOLESTEROL EFFLUX CAPACITY (APO A AND HDL CHOLESTEROL) AND PREDICT CARDIOVASCULAR EVENTS IN CHRONIC KIDNEY DISEASE, 51st Congress of the European-Renal-Association(ERA)/European-Dialysis-and-Transplant-Association (EDTA), Publisher: OXFORD UNIV PRESS, Pages: 409-410, ISSN: 0931-0509

Conference paper

Poesen R, Viaene L, Bammens B, Claes K, Evenepoel P, Meijers B, Bozic M, De Pablo C, Alvarez A, Sanchez-Niño MD, Ortiz A, Fernandez E, Valdivielso JM, Speer T, Zewinger S, Holy EW, Stähli BE, Triem S, Cvija H, Rohrer L, Seiler S, Heine GH, Jankowski V, Jankowski J, Camici G, Akhmedov A, Lüscher TF, Tanner FC, Fliser D, Isoyama N, Leurs P, Qureshi AR, Anderstam B, Heimburger O, Barany P, Stenvinkel P, Lindholm B, Bolasco P, Palleschi S, Rossi B, Atti M, Amore A, Coppo R, Loiacono E, Ghezzi PM, Palladino G, Caiazzo M, For The Sardinian Study Group, Di Napoli A, Tazza L, Franco F, Chicca S, Bossola M, Di Lallo D, Michelozzi P, Davoli M, Lucisano S, Arena A, Lupica R, Cernaro V, Trimboli D, Aloisi C, Montalto G, Santoro D, Buemi M, Burtey S, Poitevin S, Darbousset R, Gondouin B, Dubois C, Erkmen Uyar M, Bal Z, Bayraktar N, Gurlek Demirci B, Sayin B, Sezer S, Rogacev K, Zawada A, Emrich I, Seiler S, Böhm M, Fliser D, Woollard K, Heine G, Gbandjaba NY, Ghalim N, Saile R, Khalil A, Fujii H, Yamashita Y, Yonekura Y, Nakai K, Kono K, Goto S, Sugano M, Goto S, Ito Y, Nishi S, Leurs P, Meuwese C, Carrero JJ, Qureshi AR, Anderstam B, Barany P, Heimburger O, Stenvinkel P, Lindholm B, Riccio E, Sabbatini M, Bellizzi V, Pisani A, Svedberg O, Stenvinkel P, Qureshi AR, Barany P, Heimburger O, Leurs P, Isoyama N, Lindholm B, Anderstam B, Barreto-Silva MI, Lemos C, Costa-Silva F, Mendes R, Bregman R, Barreto-Silva MI, Lemos C, Vargas S, Barja-Fidalgo TC, Bregman R, Sidoti A, Lusini ML, Biagioli M, Sereni L, Ghezzi PM, Caiazzo M, Palladino G, Kara E, Ahbap E, Basturk T, Koç Y, Sakaci T, Sahutoglu T, Sevinc M, Akgol C, Unsal A, Snaedal S, Qureshi AR, Carrero JJ, Heimbürger O, Stenvinkel P, Bárány P, Paliouras C, Haviatsos T, Lamprianou F, Papagiannis N, Ntetskas G, Roufas K, Karvouniaris N, Anastasakis E, Moschos N, Alivanis P, Santoro D, Ingegneri MT, Vita G, Pisacane A, Bellinghieri G, Savica V, Buemi M, Lucisano S, Kim HK, Kim SC, Kimet al., 2014, CKD NUTRITION, INFLAMMATION AND OXIDATIVE STRESS., Pages: iii406-iii418

Conference paper

Woollard KJ, Pusey CD, 2014, The heterogeneous mononuclear phagocyte system of the kidney, KIDNEY INTERNATIONAL, Vol: 85, Pages: 1011-1014, ISSN: 0085-2538

Journal article

Khamis R, Woollard K, Hyde G, Hara T, Mauskapf A, Granger D, Johnson J, Ntziachristos V, Matthews PM, Jaffer F, Haskard Det al., 2014, NEAR-INFRARED FLUORESCENCE (NIRF) WHOLE BODY AND INTRA-ARTERIAL MOLECULAR IMAGING OF OXIDIZED LDL IN EXPERIMENTAL ATHEROSCLEROSIS, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol: 63, Pages: A2150-A2150, ISSN: 0735-1097

Journal article

Ling GS, Bennett J, Woollard KJ, Szajna M, Fossati-Jimack L, Taylor PR, Scott D, Franzoso G, Cook HT, Botto Met al., 2014, Integrin CD11b positively regulates TLR4-induced signalling pathways in dendritic cells but not in macrophages, Nature Communications, Vol: 5, Pages: 1-12, ISSN: 2041-1723

Tuned and distinct responses of macrophages and dendritic cells to Toll-like receptor 4 (TLR4) activation induced by lipopolysaccharide (LPS) underpin the balance between innate and adaptive immunity. However, the molecule(s) that confer these cell-type-specific LPS-induced effects remain poorly understood. Here we report that the integrin αM (CD11b) positively regulates LPS-induced signalling pathways selectively in myeloid dendritic cells but not in macrophages. In dendritic cells, which express lower levels of CD14 and TLR4 than macrophages, CD11b promotes MyD88-dependent and MyD88-independent signalling pathways. In particular, in dendritic cells CD11b facilitates LPS-induced TLR4 endocytosis and is required for the subsequent signalling in the endosomes. Consistent with this, CD11b deficiency dampens dendritic cell-mediated TLR4-triggered responses in vivo leading to impaired T-cell activation. Thus, by modulating the trafficking and signalling functions of TLR4 in a cell-type-specific manner CD11b fine tunes the balance between adaptive and innate immune responses initiated by LPS.

Journal article

Woollard KJ, 2013, Immunological aspects of atherosclerosis, CLINICAL SCIENCE, Vol: 125, Pages: 221-235, ISSN: 0143-5221

Journal article

Khamis R, Woollard K, Chang SH, Granger DW, Boyle JJ, Johns M, Matthews PM, Haskard DOet al., 2013, The Near Infra-Red (NIRF) molecular imaging of oxidised LDL in atherosclerosis with the native autoantibody LO1, and its molecularly expressed cysteine-tagged Fab construct (LO1-Fab-cys), Congress of the European-Society-of-Cardiology (ESC), Publisher: OXFORD UNIV PRESS, Pages: 29-29, ISSN: 0195-668X

Conference paper

Jackson W, Khamis R, Haskard D, Woollard Ket al., 2013, 165 SCAVENGER RECEPTORS MEDIATE UPTAKE OF MODIFIED LDL BY CIRCULATING BLOOD MONOCYTE SUBSETS: CONSEQUENCES FOR ATHEROSCLEROSIS., Pages: A95-A96, ISSN: 1355-6037

Conference paper

Khamis R, Woollard K, Granger D, Chang S-H, Boyle JJ, Johns VM, Matthews PM, Haskard DOet al., 2013, IMAGING BEYOND THE LUMEN: NEAR INFRA-RED IN VIVO MOLECULAR IDENTIFICATION OF OXIDISED LDL IN ATHEROSCLEROSIS USING MAB LO1, AND THE GENERATION AND DEVELOPMENT OF ITS MOLECULARLY EXPRESSED CYSTEINE-TAGGED CHIMERIC FAB CONSTRUCT (LO1-FAB-CYS), Annual Conference of the British-Cardiovascular-Society (BCS), Publisher: BMJ PUBLISHING GROUP, ISSN: 1355-6037

Conference paper

Michell DL, Andrews KL, Huet O, Woollard KJ, Moore XL, Chin-Dusting JPFet al., 2012, HIGH INTRALUMINAL PRESSURE INDUCES VASCULAR INFLAMMATION, 33rd Annual Scientific Meeting of the High-Blood-Pressure-Research-Council-of-Australia (HBPRCA), Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: 491-491, ISSN: 0194-911X

Conference paper

Carlin LM, Auffray C, Satoh T, Woollard K, Geissmann Fet al., 2012, Functions and molecular mechanisms of patrolling monocytes, 6th European Meeting on Vascular Biology and Medicine (EMVBM), Publisher: ELSEVIER SCIENCE INC, Pages: 328-328, ISSN: 1537-1891

Conference paper

Woollard KJ, 2012, Immunobiology of Monocytes and Macrophages in Inflammatory Bowel Disease, CROHN'S DISEASE AND ULCERATIVE COLITIS: FROM EPIDEMIOLOGY AND IMMUNOBIOLOGY TO A RATIONAL DIAGNOSTIC AND THERAPEUTIC APPROACH, Editors: Baumgart, Publisher: SPRINGER, Pages: 169-174, ISBN: 978-1-4614-0997-7

Book chapter

Woollard KJ, 2012, Immune Cells: Monocytes and Macrophages, Chrons Disease and Ulcerative Colitis

Book chapter

Michell DL, Andrews KL, Woollard KJ, Chin-Dusting JPFet al., 2011, Imaging Leukocyte Adhesion to the Vascular Endothelium at High Intraluminal Pressure, JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, ISSN: 1940-087X

Journal article

Michell D, Andrews K, Moore XL, Huet O, Woollard K, Chin-Dusting Jet al., 2011, INCREASES IN PRESSURE INDUCES LEUKOCYTE ADHESION IN THE ENDOTHELIUM, 32nd Annual Scientific Meeting of the High Blood Pressure Research Council of Australia, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: 127-127, ISSN: 0194-911X

Conference paper

Stamatiades E, Jordan N, Carlin L, Woollard K, Geissmann Fet al., 2011, THE ROLE OF MONOCYTES IN KIDNEY DAMAGE-CELLULAR MARKERS AND THERAPEUTIC TARGETS IN LUPUS NEPHRITIS?, 10th World Congress on Inflammation, Publisher: BIRKHAUSER VERLAG AG, Pages: 187-187, ISSN: 1023-3830

Conference paper

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