Imperial College London
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Dr Karl (Gus) Zimmerman

Faculty of Medicine, Department of Brain Sciences

Research Associate
 
 
 
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Contact

 

karl.zimmerman11 Website

 
 
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Location

 

Sir Michael Uren HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Laverse:2020:braincomms/fcaa137,
author = {Laverse, E and Guo, T and Zimmerman, K and Foiani, MS and Velani, B and Morrow, P and Adejuwon, A and Bamford, R and Underwood, N and George, J and Brooke, D and OBrien, K and Cross, MJ and Kemp, SPT and Heslegrave, AJ and Hardy, J and Sharp, DJ and Zetterberg, H and Morris, HR},
doi = {braincomms/fcaa137},
journal = {Brain Communications},
pages = {1--10},
title = {Plasma glial fibrillary acidic protein and neurofilament light chain, but not tau, are biomarkers of sports-related mild traumatic brain injury},
url = {http://dx.doi.org/10.1093/braincomms/fcaa137},
volume = {2},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Mild traumatic brain injury is a relatively common event in contact sports and there is increasing interest in the long-term neurocognitive effects. The diagnosis largely relies on symptom reporting and there is a need for objective tools to aid diagnosis and prognosis. There are recent reports that blood biomarkers could potentially help triage patients with suspected injury and normal CT findings. We have measured plasma concentrations of glial and neuronal proteins and explored their potential in the assessment of mild traumatic brain injury in contact sport.We recruited a prospective cohort of active male rugby players, who had pre-season baseline plasma sampling. From this prospective cohort, we recruited 25 players diagnosed with mild traumatic brain injury. We sampled post-match rugby players without head injuries as post-match controls. We measured plasma neurofilament light chain, tau and glial fibrillary acidic protein levels using ultrasensitive single molecule array technology. The data was analysed at the group and individual player level.Plasma glial fibrillary acidic protein concentration was significantly increased 1-hour post-injury in mild traumatic brain injury cases compared to the non-injured group (p = 0.017). Pairwise comparison also showed that glial fibrillary acidic protein levels were higher in players after a head injury in comparison to their pre-season levels at both 1-hour and 3 to 10-days post-injury time points (p = 0.039 and 0.040, respectively). There was also an increase in neurofilament light chain concentration in brain injury cases compared to the pre-season levels within the same individual at both time points (p = 0.023 and 0.002, respectively). Tau was elevated in both the non-injured control group and the 1-hour post-injury group compared to pre-season levels (p = 0.007 and 0.015, respectively). Furthermore, receiver operating characteristic analysis showed that glial
AU  - Laverse,E
AU  - Guo,T
AU  - Zimmerman,K
AU  - Foiani,MS
AU  - Velani,B
AU  - Morrow,P
AU  - Adejuwon,A
AU  - Bamford,R
AU  - Underwood,N
AU  - George,J
AU  - Brooke,D
AU  - OBrien,K
AU  - Cross,MJ
AU  - Kemp,SPT
AU  - Heslegrave,AJ
AU  - Hardy,J
AU  - Sharp,DJ
AU  - Zetterberg,H
AU  - Morris,HR
DO  - braincomms/fcaa137
EP  - 10
PY  - 2020///
SN  - 2632-1297
SP  - 1
TI  - Plasma glial fibrillary acidic protein and neurofilament light chain, but not tau, are biomarkers of sports-related mild traumatic brain injury
T2  - Brain Communications
UR  - http://dx.doi.org/10.1093/braincomms/fcaa137
UR  - https://academic.oup.com/braincomms/article/2/2/fcaa137/5902445
UR  - http://hdl.handle.net/10044/1/83540
VL  - 2
ER  -
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