Imperial College London
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Dr Kate Mitchell

Faculty of Medicine, School of Public Health

Honorary Senior Research Fellow
 
 
 
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Contact

 

+44 (0)20 7594 3342kate.mitchell Website

 
 
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Location

 

UG4Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Silhol:2020:10.1097/QAI.0000000000002340,
author = {Silhol, R and Boily, M-C and Dimitrov, D and German, D and Flynn, C and Farley, JE and Gelman, M and Hughes, JP and Donnell, D and Adeyeye, A and Remien, RH and Beyrer, C and Paz-Bailey, G and Wejnert, C and Mitchell, KM},
doi = {10.1097/QAI.0000000000002340},
journal = {JAIDS: Journal of Acquired Immune Deficiency Syndromes},
pages = {253--262},
title = {Understanding the HIV epidemic among MSM in Baltimore: a modelling study estimating the impact of past HIV interventions and who acquired and contributed to infections.},
url = {http://dx.doi.org/10.1097/QAI.0000000000002340},
volume = {84},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - INTRODUCTION: Men who have sex with men (MSM) in the United States (US) are disproportionately affected by HIV. We estimated the impact of past interventions and contribution of different population groups to incident MSM HIV infections. SETTING: Baltimore, US METHODS:: We used a deterministic model, parameterised and calibrated to demographic and epidemic Baltimore MSM data, to estimate the fraction of HIV infections among MSM averted by condoms and antiretroviral therapy (ART) over 1984-2017 and the fraction of infections acquired and transmission contributed by MSM from different demographic groups and disease and care continuum stages over 10-year periods from 1988 to 2017, using population attributable fractions (PAFs). RESULTS: Condom use and ART averted 19% (95% uncertainty interval: 14-25%) and 23% (15-31%) of HIV infections that would have occurred since 1984 and 1996, respectively. Over 2008-2017, 46% (41-52%) of incident infections were acquired by, and 35% (27-49%) of transmissions contributed by MSM aged 18-24 years old (who constitute 27% of all MSM, 19% of HIV+ MSM). MSM with undiagnosed HIV infection, those with diagnosed infection but not in care, and those on ART contributed to 41% (31-54%), 46% (25-56%), and 14% (7-28%) of transmissions, respectively. CONCLUSION: Condoms and ART have modestly impacted the HIV epidemic among Baltimore MSM to date. Interventions reaching MSM with diagnosed infection who are not in care should be implemented since the largest percentage of HIV transmissions among Baltimore MSM are attributed to this group.
AU  - Silhol,R
AU  - Boily,M-C
AU  - Dimitrov,D
AU  - German,D
AU  - Flynn,C
AU  - Farley,JE
AU  - Gelman,M
AU  - Hughes,JP
AU  - Donnell,D
AU  - Adeyeye,A
AU  - Remien,RH
AU  - Beyrer,C
AU  - Paz-Bailey,G
AU  - Wejnert,C
AU  - Mitchell,KM
DO  - 10.1097/QAI.0000000000002340
EP  - 262
PY  - 2020///
SN  - 1525-4135
SP  - 253
TI  - Understanding the HIV epidemic among MSM in Baltimore: a modelling study estimating the impact of past HIV interventions and who acquired and contributed to infections.
T2  - JAIDS: Journal of Acquired Immune Deficiency Syndromes
UR  - http://dx.doi.org/10.1097/QAI.0000000000002340
UR  - https://www.ncbi.nlm.nih.gov/pubmed/32141958
UR  - https://journals.lww.com/jaids/Abstract/publishahead/Understanding_the_HIV_epidemic_among_MSM_in.96217.aspx
UR  - http://hdl.handle.net/10044/1/77359
VL  - 84
ER  -
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