Imperial College London
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DrKeithFraser

Faculty of Medicine, School of Public Health

Research Associate
 
 
 
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Contact

 

keith.fraser Website

 
 
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Location

 

School of Public HealthWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@unpublished{Fraser:2020:rs.3.rs-72317/v1,
author = {Fraser, KJ and Mwandigha, L and Traore, S and Traore, M and Doumbia, S and Junnila, A and Revay, E and Beier, J and Marshall, J and Ghani, A and Muller, G},
doi = {rs.3.rs-72317/v1},
title = {Estimating the potential impact of Attractive Targeted Sugar Baits (ATSBs) as a new vector control tool for Plasmodium falciparum malaria},
url = {http://dx.doi.org/10.21203/rs.3.rs-72317/v1},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - UNPB
AB  - <jats:title>Abstract</jats:title>        <jats:p><jats:bold>Background:</jats:bold> Attractive targeted sugar baits (ATSBs) are a promising new tool for malaria control as they can target outdoor-feeding mosquito populations, in contrast to current vector control tools which predominantly target indoor-feeding mosquitoes. <jats:bold>Methods: </jats:bold>We sought to estimate the potential impact of these new tools on <jats:italic>Plasmodium falciparum</jats:italic> malaria prevalence in African settings by combining data from a recent entomological field trial of ATSBs undertaken in Mali with mathematical models of malaria transmission. <jats:bold>Results:</jats:bold> The entomological study showed a significant reduction of 55.4% (95 % CI 33.7-77.1%) in mosquito catch numbers, and a larger reduction of ~91% (95% CI 75-100%) in the entomological inoculation rate due to the fact that, in the presence of ATSBs, most mosquitoes do not live long enough to transmit malaria. The key parameter determining impact on the mosquito population is the excess mortality due to ATSBs, which we estimate from the observed reduction in mosquito catch numbers to be lower (mean 0.13 per mosquito per day, seasonal range 0.10-0.16 per day) than the bait feeding rate obtained from one-day staining tests (mean 0.34 per mosquito per day, seasonal range 0.28-0.38 per day). Using a mathematical model capturing the lifecycle of <jats:italic>P. falciparum</jats:italic> malaria in mosquitoes and humans and incorporating the excess mortality, we predict that ATSBs could result in large reductions (>30% annually) in prevalence and clinical incidence of malaria, even in regions with an existing high malaria burden. <jats:bold>Conclusions: </jats:bold>Results suggest that this new tool could provide a promising addition to existing vector control tools and result in significant reductions in malaria burde
AU  - Fraser,KJ
AU  - Mwandigha,L
AU  - Traore,S
AU  - Traore,M
AU  - Doumbia,S
AU  - Junnila,A
AU  - Revay,E
AU  - Beier,J
AU  - Marshall,J
AU  - Ghani,A
AU  - Muller,G
DO  - rs.3.rs-72317/v1
PY  - 2020///
TI  - Estimating the potential impact of Attractive Targeted Sugar Baits (ATSBs) as a new vector control tool for Plasmodium falciparum malaria
UR  - http://dx.doi.org/10.21203/rs.3.rs-72317/v1
ER  -
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