Imperial College London


Faculty of Natural SciencesDepartment of Chemistry

Chair in Chemical Biology



+44 (0)20 7594 5837keith.willison Website CV




301FMolecular Sciences Research HubWhite City Campus





The group’s research interests cover a range of topics including eukaryotic protein folding and single molecule approaches to protein dynamics and protein counting. Everything we do involves interdisciplinary approaches to biological research problems – we collaborate with physicists, mathematicians and engineers across Imperial College.

We were founder members of the  Centre for Doctoral Training in Chemical Biology and the Institute of Chemical Biology. The EPSRC-funded CDT started life in 2003 and was recently renewed for a 4th round of student intake from 2019-2024. In the first three CDT programmes we trained around 150 PhDs in Chemical Biology subjects ranging from optics, spectroscopies, microfluidics and other physical science-based platforms to biological problems such as artificial vesicles/cells and cancer drug discovery.



Ying L, Tahirbegi B, Magness A, et al., 2020, A novel Aβ40 assembly at physiological concentration, Scientific Reports, Vol:10, ISSN:2045-2322

Wang X, Wilkinson MD, Lin X, et al., 2020, Single-molecule nanopore sensing of actin dynamics and drug binding, Chemical Science, Vol:11, ISSN:2041-6520, Pages:970-979

Sowley H, Liu Z, Davies J, et al., 2019, Detection of drug binding to a target protein using EVV 2DIR spectroscopy, Journal of Physical Chemistry B, Vol:123, ISSN:1520-5207, Pages:3598-3606

Paulose Nadappuram B, Cadinu P, Barik A, et al., 2019, Nanoscale tweezers for single cell biopsies, Nature Nanotechnology, Vol:14, ISSN:1748-3387, Pages:80-88

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