Imperial College London
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ProfessorKeithWillison

Faculty of Natural Sciences, Department of Chemistry

Chair in Chemical Biology
 
 
 
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Contact

 

+44 (0)20 7594 5837keith.willison Website CV

 
 
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Location

 

301FMolecular Sciences Research HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@inproceedings{Tahirbegi:2018:10.1016/j.bpj.2017.11.2383,
author = {Tahirbegi, B and Magness, AJ and Boillat, A and Willison, KR and Klug, DR and Knopfel, T and Ying, L},
doi = {10.1016/j.bpj.2017.11.2383},
pages = {430A--430A},
publisher = {Biophysical Society},
title = {Probing synaptic amyloid-beta aggregation promoted by copper release},
url = {http://dx.doi.org/10.1016/j.bpj.2017.11.2383},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - CPAPER
AB  - Whether or not the metal ions released during synaptic transmission induce amyloid-beta oligomer formation in the vicinity of synapses is a central question pertinent to the molecular mechanism of Alzheimer's disease. Recently, through a combination of experimental kinetics studies and coupled reaction-diffusion simulations, we predicted that Cu(II) rather than Zn(II) plays an important role in the very early stages (i.e., dimer formation) of Aβ aggregation in the synapse. Single molecule photobleaching analysis is a powerful tool to determine the stoichiometry of amyloid-beta oligomers which enables us to examine the time course of small amyloid-beta oligomer formation in solution, immobilised to a solid-phase substrate or artificial lipid membrane, and in live neurons in the presence of Cu(II). Preliminary results indicate that small amyloid-beta oligomers can be locked in their oligomeric state without dissociation on a poly-lysine coated surface and that Cu(II) increases the diversity and abundance of amyloid-beta oligomers.
AU  - Tahirbegi,B
AU  - Magness,AJ
AU  - Boillat,A
AU  - Willison,KR
AU  - Klug,DR
AU  - Knopfel,T
AU  - Ying,L
DO  - 10.1016/j.bpj.2017.11.2383
EP  - 430
PB  - Biophysical Society
PY  - 2018///
SN  - 0006-3495
SP  - 430
TI  - Probing synaptic amyloid-beta aggregation promoted by copper release
UR  - http://dx.doi.org/10.1016/j.bpj.2017.11.2383
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000430450000644&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/60796
ER  -
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