Imperial College London
Alternate

Emeritus ProfessorKimFox

Faculty of Medicine, National Heart & Lung Institute

Emeritus Professor
 
 
 
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Contact

 

+44 (0)20 7594 7966kim.fox

 
 
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Assistant

 

Ms Deborah Curcher +44 (0)20 7594 7966

 
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Location

 

Guy Scadding BuildingRoyal Brompton Campus

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Summary

 

Publications

Citation

BibTex format

@article{Biscaglia:2020:10.1177/2047487319871217,
author = {Biscaglia, S and Campo, G and Sorbets, E and Ford, I and Fox, K and Greenlaw, N and Parkhomenko, O and Tardif, J-C and Tavazzi, L and Tendera, M and Wetherall, K and Ferrari, R and Steg, G},
doi = {10.1177/2047487319871217},
journal = {European Journal of Preventive Cardiology},
pages = {426--436},
title = {Relationship between physical activity  and long-term outcomes in patients with stable coronary artery disease},
url = {http://dx.doi.org/10.1177/2047487319871217},
volume = {27},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - AIMS To ascertain the relationship between level of physical activity and outcomes and to discriminate the determinants of physical activity performance or avoidance.METHODS CLARIFY is an international prospective registry of 32370 consecutive outpatients with stable coronary artery disease who were followed for up to 5 years. Patients were grouped according to the level and frequency of physical activity: i) sedentary (n=5223; 16.1%); ii) only light physical activity most weeks (light; n=16634; 51.4%); iii) vigorous physical activity once or twice per week (vigorous ≤2×; n=5427; 16.8%); iv) vigorous physical activity three or more times per week (vigorous >2×; n=5086; 15.7%). The primary outcome was the composite of cardiovascular death, myocardial infarction, and stroke.RESULTS Patients performing vigorous physical activity ≤2× had the lowest risk of the primary outcome (hazard ratio [HR], 0.82; 95% confidence interval [CI], 0.71-0.93; P = .0031) taking the light group as reference. Engaging in more frequent exercise did not result in further outcome benefit. All-cause death, cardiovascular death, and stroke occurred less frequently in patients performing vigorous physical activity ≤2×. However, the rate of myocardial infarction was comparable between the four physical activity groups. Female sex, peripheral artery disease, diabetes, previous myocardial infarction or stroke, pulmonary disease, and body mass index all emerged as independent predictors of lower physical activity.CONCLUSION Vigorous physical activity once or twice per week was associated with superior cardiac outcomes compared to patients performing no or a low level of physical activity in outpatients with stable coronary artery disease.
AU  - Biscaglia,S
AU  - Campo,G
AU  - Sorbets,E
AU  - Ford,I
AU  - Fox,K
AU  - Greenlaw,N
AU  - Parkhomenko,O
AU  - Tardif,J-C
AU  - Tavazzi,L
AU  - Tendera,M
AU  - Wetherall,K
AU  - Ferrari,R
AU  - Steg,G
DO  - 10.1177/2047487319871217
EP  - 436
PY  - 2020///
SN  - 2047-4873
SP  - 426
TI  - Relationship between physical activity  and long-term outcomes in patients with stable coronary artery disease
T2  - European Journal of Preventive Cardiology
UR  - http://dx.doi.org/10.1177/2047487319871217
UR  - https://journals.sagepub.com/doi/suppl/10.1177/2047487319871217
UR  - http://hdl.handle.net/10044/1/73570
VL  - 27
ER  -
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