Imperial College London
Alternate

Emeritus ProfessorKimFox

Faculty of Medicine, National Heart & Lung Institute

Emeritus Professor
 
 
 
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Contact

 

+44 (0)20 7594 7966kim.fox

 
 
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Assistant

 

Ms Deborah Curcher +44 (0)20 7594 7966

 
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Location

 

Guy Scadding BuildingRoyal Brompton Campus

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Summary

 

Publications

Citation

BibTex format

@article{Parma:2020:10.1002/ejhf.1827,
author = {Parma, Z and Jasilek, A and Greenlaw, N and Ferrari, R and Ford, I and Tardiff, J-C and Fox, K and Tendera, M},
doi = {10.1002/ejhf.1827},
journal = {European Journal of Heart Failure},
pages = {804--812},
title = {Incident heart failure in outpatients with chronic coronary syndrome: results from the international prospective CLARIFY registry},
url = {http://dx.doi.org/10.1002/ejhf.1827},
volume = {22},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - AimThe contemporary incidence of heart failure (HF) in patients with chronic coronary syndrome is unclear. We aimed to study the incidence and predictors of cardiovascular (CV) death, HF hospitalization or newonset HF not requiring hospitalization, in patients included in the CLARIFY registry.Methods and resultsCLARIFY is a contemporary, international registry of ambulatory patients with chronic coronary artery disease, conducted in 45 countries. At baseline, data on demographics, ethnicity, CV risk factors, medical history, cardiac parameters and medication were collected. Patients were followed up yearly up to 5 years. In this analysis, 26 769 patients with no HF history were included. At 5year followup, 4393 patients (16.4%) reached the primary endpoint comprising CV death, HF hospitalization, or newonset HF. Only 16.7% of them (n = 732) required hospitalization for HF. Allcause death occurred in 6.6% of patients (61.4% were CV). Age over 70 years, left ventricular ejection fraction <50%, Canadian Cardiovascular Society class ≥2 angina, atrial fibrillation or paced rhythm on the ECG, body mass index <20 kg/m2, and a history of stroke, were the most robust predictors of the primary outcome. Age <50 years, Asian ethnicity, and percutaneous revascularization were negative predictors of the outcome.ConclusionA sizeable proportion of patients with chronic coronary syndrome develop HF, which only infrequently requires hospitalization. Early identification of patients with HF may lead to early treatment, and help to further decrease mortality and morbidity. This concept needs confirmation in future studies.
AU  - Parma,Z
AU  - Jasilek,A
AU  - Greenlaw,N
AU  - Ferrari,R
AU  - Ford,I
AU  - Tardiff,J-C
AU  - Fox,K
AU  - Tendera,M
DO  - 10.1002/ejhf.1827
EP  - 812
PY  - 2020///
SN  - 1388-9842
SP  - 804
TI  - Incident heart failure in outpatients with chronic coronary syndrome: results from the international prospective CLARIFY registry
T2  - European Journal of Heart Failure
UR  - http://dx.doi.org/10.1002/ejhf.1827
UR  - https://onlinelibrary.wiley.com/doi/full/10.1002/ejhf.1827
UR  - http://hdl.handle.net/10044/1/78458
VL  - 22
ER  -
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