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@article{Mak:2021:eurjpc/zwab011,
author = {Mak, K-H and Vidal-Petiot, E and Young, R and Sorbets, E and Greenlaw, N and Ford, I and Tendera, M and Ferrari, R and Tardiff, J-C and Udell, JA and Escobedo, J and Fox, K and Steg, PG},
doi = {eurjpc/zwab011},
journal = {European Journal of Preventive Cardiology},
pages = {1795--1806},
title = {Prevalence of diabetic and impact on cardiovascular events and mortality in patients with chronic coronary syndromes, across multiple geographical regions and ethnicities},
url = {http://dx.doi.org/10.1093/eurjpc/zwab011},
volume = {28},
year = {2021}
}

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TY  - JOUR
AB  - Background: In contrast with the setting of acute myocardial infarction, there are limited data regarding the impact of diabetes mellitus on clinical outcomes in contemporary cohorts of patients with chronic coronary syndromes. We aimed to investigate the prevalence and prognostic impact of diabetes according to geographical regions and ethnicity. Methods: CLARIFY is an observational registry of patients with chronic coronary syndromes, enrolled across 45 countries in Europe, Asia, America, Middle East, Australia and Africa in 2009-2010, and followed-up yearly for 5 years. Chronic coronary syndromes were defined by ≥1 of the following criteria: prior myocardial infarction, evidence of coronary stenosis >50%, proven symptomatic myocardial ischemia, or prior revascularisation procedure. Results: Among 32,694patients, 9502 (29%) had diabetes, with a regional prevalence ranging from below 20% in Northern Europe to approximately 60% in the Gulf countries. In a multivariable-adjusted Cox proportional hazards model, diabetes was associated with increased risks for the primary outcome(cardiovascular death, myocardial infarction or stroke)with an adjusted hazard ratio of1.28(95% CI 1.18-1.39) and for all secondary outcomes (all-cause and cardiovascular mortality, myocardial infarction, stroke, heart failure and coronary revascularization). Differences on outcomes according to geography and ethnicity were modest. Conclusion: In patients with chronic coronary syndromes, diabetes is independently associated with mortality and cardiovascular events, including heart failure, which is not accounted by demographics, prior medical history, left ventricular ejection fraction, or use of secondary prevention medication. This is observed across multiple geographic regions and ethnicities, despite marked disparities in the prevalence of diabetes.
AU  - Mak,K-H
AU  - Vidal-Petiot,E
AU  - Young,R
AU  - Sorbets,E
AU  - Greenlaw,N
AU  - Ford,I
AU  - Tendera,M
AU  - Ferrari,R
AU  - Tardiff,J-C
AU  - Udell,JA
AU  - Escobedo,J
AU  - Fox,K
AU  - Steg,PG
DO  - eurjpc/zwab011
EP  - 1806
PY  - 2021///
SN  - 2047-4873
SP  - 1795
TI  - Prevalence of diabetic and impact on cardiovascular events and mortality in patients with chronic coronary syndromes, across multiple geographical regions and ethnicities
T2  - European Journal of Preventive Cardiology
UR  - http://dx.doi.org/10.1093/eurjpc/zwab011
UR  - http://hdl.handle.net/10044/1/86817
VL  - 28
ER  -

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