Imperial College London
Alternate

Emeritus ProfessorKimFox

Faculty of Medicine, National Heart & Lung Institute

Emeritus Professor
 
 
 
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Contact

 

+44 (0)20 7594 7966kim.fox

 
 
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Assistant

 

Ms Deborah Curcher +44 (0)20 7594 7966

 
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Location

 

Guy Scadding BuildingRoyal Brompton Campus

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Summary

 

Publications

Citation

BibTex format

@article{Bouabdallaoui:2021:10.1177/2047487320918728,
author = {Bouabdallaoui, N and Messas, N and Greenlaw, N and Ferrari, R and Ford, I and Fox, KM and Tendera, M and P, Naidoo D and Hassager, C and Gabriel, Steg P and Tardif, J-C and CLARIFY, Investigators},
doi = {10.1177/2047487320918728},
journal = {Eur J Prev Cardiol},
pages = {1460--1466},
title = {Impact of smoking on cardiovascular outcomes in patients with stable coronary artery disease.},
url = {http://dx.doi.org/10.1177/2047487320918728},
volume = {28},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - AIMS: Smoking is a major preventable risk factor for cardiovascular disease and mortality. However, the 'smoker's paradox' suggests that it is associated with better survival after acute myocardial infarction. We aimed to investigate the impact of smoking on mortality and cardiovascular outcomes in patients with stable coronary artery disease. METHODS: The international CLARIFY registry included 32,703 patients with stable coronary artery disease between 2009 and 2010. Among the 32,378 patients included in the present analysis, Cox proportional hazards models (adjusted for age, sex, geographic region, prior myocardial infarction, and revascularization status) were used to estimate associations between smoking status and outcomes. Patients were stratified as follows: 41.3% of patients never smoked, 12.5% were current smokers and 46.2% were former smokers. RESULTS: Current smokers were younger than never-smokers and former smokers (59 vs. 66 and 64 years old, respectively, p < 0.0001). There were more men among current or former smokers compared with never-smokers. Compared with never-smokers, both current and former smokers were at higher risk of all-cause death (hazard ratio = 1.96 and 1.37) and cardiovascular death (hazard ratio = 1.92 and 1.38) within five years (all p < 0.05). Similarly graded and increased risks were present for myocardial infarction and the composite of cardiovascular death, myocardial infarction and stroke (all p < 0.05). CONCLUSION: In contrast to the 'smoker's paradox', current smokers with stable coronary artery disease have a greatly increased risk of future cardiovascular events, including mortality, compared with never-smokers. In former smokers, cardiovascular risk remains elevated albeit at an intermediate level between that of current and never-smokers, reinforcing the importance of smoking cessation. (ISRCTN43070564).
AU  - Bouabdallaoui,N
AU  - Messas,N
AU  - Greenlaw,N
AU  - Ferrari,R
AU  - Ford,I
AU  - Fox,KM
AU  - Tendera,M
AU  - P,Naidoo D
AU  - Hassager,C
AU  - Gabriel,Steg P
AU  - Tardif,J-C
AU  - CLARIFY,Investigators
DO  - 10.1177/2047487320918728
EP  - 1466
PY  - 2021///
SP  - 1460
TI  - Impact of smoking on cardiovascular outcomes in patients with stable coronary artery disease.
T2  - Eur J Prev Cardiol
UR  - http://dx.doi.org/10.1177/2047487320918728
UR  - https://www.ncbi.nlm.nih.gov/pubmed/34695217
VL  - 28
ER  -
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