Imperial College London

Dr Alan King Lun Liu

Faculty of MedicineDepartment of Brain Sciences

Honorary Clinical Research Fellow







Burlington DanesHammersmith Campus





I am a post-doctoral research neuropathologist and a medical doctor graduated from Imperial College School of Medicine in 2018. During my medical degree, I obtained a joint-PhD from Imperial College and the University of Hong Kong with a thesis titled "Clinicopathological investigations of the cholinergic basal forebrain in Lewy body disorders and ageing". Currently, I am the NIHR Academic Clinical Fellow in Neurology at the University of Oxford, an honorary research fellow at Imperial College London and an honorary clinical fellow at University of Liverpool specialising in the non-motor and non-dopaminergic aspects of Lewy body disorders. My research expertise includes the study of human basal forebrain cholinergic system in neurodegenerative diseases and the clinicopathological correlations of non-motor symptoms in Parkinson's disease. I have also pioneered the development of next-generation tissue clearing in human brain tissues, a novel technique which enables three-dimensional visualisation of anatomical structures.

I have served as a council member of the Clinical Neurosciences Section of the Royal Society of Medicine for 7 years and I am currently a member of the British Neuropathological Society. I was part of the founding committee (2012-13) and co-president (2013-14) of the Imperial College Neuroscience Society with the aim to make neuroscience more accessible to students. Subsequently, I co-founded the London Students' Neuroscience Network (LSNeuroN) with representatives from 4 other university neuroscience societies in London (QMBL, UCL, KCL and St. Georges).

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Selected Publications

Journal Articles

Liu KL, Chau TW, Lim EJ, et al., 2019, Hippocampal CA2 Lewy pathology is associated with cholinergic degeneration in Parkinson’s disease with cognitive decline, Acta Neuropathologica Communications, Vol:7, ISSN:2051-5960

Liu AKL, Lim EJ, Ahmed I, et al., 2018, Review: revisiting the human cholinergic nucleus of the diagonal band of Broca, Neuropathology and Applied Neurobiology, Vol:44, ISSN:0305-1846, Pages:647-662

Lai HM, Liu KL, Ng HHM, et al., 2018, Next generation histology methods for three-dimensional imaging of fresh and archival human brain tissues, Nature Communications, Vol:9, ISSN:2041-1723

Liu AKL, Hurry MED, Ng OTW, et al., 2015, Bringing CLARITY to the human brain: visualization of Lewy pathology in three dimensions, Neuropathology and Applied Neurobiology, Vol:42, ISSN:1365-2990, Pages:573-587

Liu AKL, Chang RC-C, Pearce RKB, et al., 2015, Nucleus basalis of Meynert revisited: anatomy, history and differential involvement in Alzheimer's and Parkinson's disease, Acta Neuropathologica, Vol:129, ISSN:0001-6322, Pages:527-540

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