Imperial College London
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Dr Alan King Lun Liu

Faculty of Medicine, Department of Brain Sciences

Honorary Clinical Research Fellow
 
 
 
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Contact

 

king.liu09

 
 
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Location

 

Burlington DanesHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Liu:2018:10.1111/nan.12513,
author = {Liu, AKL and Lim, EJ and Ahmed, I and Chang, RC-C and Pearce, RKB and Gentleman, SM},
doi = {10.1111/nan.12513},
journal = {Neuropathology and Applied Neurobiology},
pages = {647--662},
title = {Review: revisiting the human cholinergic nucleus of the diagonal band of Broca},
url = {http://dx.doi.org/10.1111/nan.12513},
volume = {44},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Although the nucleus of the vertical limb of the diagonal band of Broca (nvlDBB) is the second largest cholinergic nucleus in the basal forebrain, after the nucleus basalis of Meynert (nbM), it has not generally been a focus for studies of neurodegenerative disorders. However, the nvlDBB does have an important projection to the hippocampus and discrete lesions of the rostral basal forebrain have been shown to disrupt retrieval memory function, a major deficit seen in patients with Lewy body disorders. One reason for its neglect is that the anatomical boundaries of the nvlDBB are ill defined and this area of the brain is not part of routine diagnostic sampling protocols. We have reviewed the history and anatomy of the nvlDBB and now propose guidelines for distinguishing nvlDBB from other neighbouring cholinergic cell groups for standardising future clinicopathological work. Thorough review of the literature regarding neurodegenerative conditions reveals inconsistent results in terms of cholinergic neuronal loss within the nvlDBB. This is likely to be due to the use of variable neuronal inclusion criteria and omission of cholinergic immunohistochemical markers. Extrapolating from those studies showing significant nvlDBB neuronal loss in Lewy body dementia, we propose an anatomical and functional connection between the cholinergic component of the nvlDBB (Ch2) and the CA2 subfield in the hippocampus which may be especially vulnerable in Lewy body disorders. This article is protected by copyright. All rights reserved.
AU  - Liu,AKL
AU  - Lim,EJ
AU  - Ahmed,I
AU  - Chang,RC-C
AU  - Pearce,RKB
AU  - Gentleman,SM
DO  - 10.1111/nan.12513
EP  - 662
PY  - 2018///
SN  - 0305-1846
SP  - 647
TI  - Review: revisiting the human cholinergic nucleus of the diagonal band of Broca
T2  - Neuropathology and Applied Neurobiology
UR  - http://dx.doi.org/10.1111/nan.12513
UR  - https://www.ncbi.nlm.nih.gov/pubmed/30005126
UR  - https://onlinelibrary.wiley.com/doi/full/10.1111/nan.12513
UR  - http://hdl.handle.net/10044/1/62115
VL  - 44
ER  -
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