Imperial College London
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Dr Kiran Haresh Kumar Patel

Faculty of Medicine, National Heart & Lung Institute

Honorary Clinical Lecturer
 
 
 
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Contact

 

kiran.patel

 
 
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Location

 

ICTEM buildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Patel:2021:10.1186/s12902-021-00805-7,
author = {Patel, K and Li, X and Quint, J and Ware, J and Peters, N and Ng, FS},
doi = {10.1186/s12902-021-00805-7},
journal = {BMC Endocrine Disorders},
pages = {1--6},
title = {Increasing adiposity and the presence of cardiometabolic morbidity is associated with increased Covid-19-related mortality: results from the UK Biobank},
url = {http://dx.doi.org/10.1186/s12902-021-00805-7},
volume = {21},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Background: Although obesity, defined by body mass index (BMI), has been associated with a higher risk of hospitalisation and more severe course of illness in Covid-19 positive patients amongst the British population, it is unclear if this translates into increased mortality. Furthermore, given that BMI is an insensitive indicator of adiposity, the effect of adipose volume on Covid-19 outcomes is also unknown. Methods: We used the UK Biobank repository, which contains clinical and anthropometric data, and is linked to Public Health England Covid-19 healthcare records, to address our research question. We performed age- and sex- adjusted logistic regression and Chi-squared test to compute the odds for Covid-19-related mortality as a consequence of increasing BMI, other more sensitive indices of adiposity such as waist:hip ratio (WHR) and percent body fat, as well as concomitant cardiometabolic illness.Results: 13502 participants were tested for Covid-19 (mean age 70+8 years, 48.9% male). 1,582 tested positive (mean age 68+9 years, 52.8% male), of which 305 died (mean age 75+6 years, 65.5% male). Increasing adiposity was associated with higher odds for Covid-19-related mortality.  For every unit increase in BMI, WHR and percent body fat, the odds of death amongst the Covid19-positive participants increased by 1.04 (95% CI 1.01-1.07), 10.71 (95% CI 1.57-73.06) and 1.03 (95% CI 1.01-1.05), respectively (all p<0.05). Referenced to Covid-19 positive participants with a normal weight (BMI 18.5-25kg/m2), Covid-19 positive participants with BMI>35kg/m2 had significantly higher odds of Covid-19-related death (OR 1.70, 95% CI 1.06-2.74, p<0.05).  Covid-19-positive participants with metabolic (diabetes, hypertension, dyslipidaemia) or cardiovascular morbidity (atrial fibrillation, angina) also had higher odds of death.Conclusions: Anthropometric indices that are more sensitive to adipose volume and its distribution than BMI, as well as concurrent cardiometabolic illnes
AU  - Patel,K
AU  - Li,X
AU  - Quint,J
AU  - Ware,J
AU  - Peters,N
AU  - Ng,FS
DO  - 10.1186/s12902-021-00805-7
EP  - 6
PY  - 2021///
SN  - 1472-6823
SP  - 1
TI  - Increasing adiposity and the presence of cardiometabolic morbidity is associated with increased Covid-19-related mortality: results from the UK Biobank
T2  - BMC Endocrine Disorders
UR  - http://dx.doi.org/10.1186/s12902-021-00805-7
UR  - https://bmcendocrdisord.biomedcentral.com/articles/10.1186/s12902-021-00805-7
UR  - http://hdl.handle.net/10044/1/89832
VL  - 21
ER  -
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