Imperial College London
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Dr Kiran Haresh Kumar Patel

Faculty of Medicine, National Heart & Lung Institute

Honorary Clinical Lecturer
 
 
 
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Contact

 

kiran.patel

 
 
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Location

 

ICTEM buildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Patel:2021:10.1152/ajpheart.00565.2021,
author = {Patel, K and Hwang, T and Se, Liebers C and Ng, FS},
doi = {10.1152/ajpheart.00565.2021},
journal = {American Journal of Physiology: Heart and Circulatory Physiology},
title = {Epicardial adipose tissue as a mediator of cardiac arrhythmias},
url = {http://dx.doi.org/10.1152/ajpheart.00565.2021},
volume = {322},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Obesity is associated with higher risks of cardiac arrhythmias. Although this may be partly explained by concurrent cardiometabolic ill-health, growing evidence suggests that increasing adiposity independently confers risk for arrhythmias. Amongst fat depots, epicardial adipose tissue (EAT) exhibits a proinflammatory secretome, and given the lack of fascial separation, has been implicated as a transducer of inflammation to the underlying myocardium. The present review explores the mechanisms underpinning adverse electrophysiological remodelling as a consequence of EAT accumulation and the consequent inflammation. We first describe the physiological and pathophysiological function of EAT and its unique secretome, and subsequently discuss the evidence for ionic channel and connexin expression modulation as well as fibrotic remodelling induced by cytokines and free fatty acids that are secreted by EAT. Finally, we highlight how weight reduction and regression of EAT volume may cause reverse remodelling to ameliorate arrhythmic risk.
AU  - Patel,K
AU  - Hwang,T
AU  - Se,Liebers C
AU  - Ng,FS
DO  - 10.1152/ajpheart.00565.2021
PY  - 2021///
SN  - 0363-6135
TI  - Epicardial adipose tissue as a mediator of cardiac arrhythmias
T2  - American Journal of Physiology: Heart and Circulatory Physiology
UR  - http://dx.doi.org/10.1152/ajpheart.00565.2021
UR  - https://journals.physiology.org/doi/full/10.1152/ajpheart.00565.2021
UR  - http://hdl.handle.net/10044/1/93194
VL  - 322
ER  -
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