Imperial College London
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Dr Kiran Haresh Kumar Patel

Faculty of Medicine, National Heart & Lung Institute

Honorary Clinical Lecturer
 
 
 
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Contact

 

kiran.patel

 
 
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Location

 

ICTEM buildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Sau:2022:10.1161/JAHA.121.024260,
author = {Sau, A and Kaura, A and Ahmed, A and Patel, KHK and Li, X and Mulla, A and Glampson, B and Panoulas, V and Davies, J and Woods, K and Gautama, S and Shah, AD and Elliott, P and Hemingway, H and Williams, B and Asselbergs, FW and Melikian, N and Peters, NS and Shah, AM and Perera, D and Kharbanda, R and Patel, RS and Channon, KM and Mayet, J and Ng, FS},
doi = {10.1161/JAHA.121.024260},
journal = {Journal of the American Heart Association},
pages = {1--19},
title = {Prognostic significance of ventricular arrhythmias in 13444 patients with acute coronary syndrome: a retrospective cohort study based on routine clinical data (NIHR Health Informatics Collaborative VA-ACS Study)},
url = {http://dx.doi.org/10.1161/JAHA.121.024260},
volume = {11},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Background: A minority of acute coronary syndrome (ACS) cases are associated with ventricular arrhythmias (VA) and/or cardiac arrest (CA). We investigated the effect of VA/CA at time of ACS on long-term outcomes.Methods and Results: We analysed routine clinical data from 5 NHS Trusts in the United Kingdom, collected between 2010 and 2017, by the National Institute for Health Research Health Informatics Collaborative (NIHR HIC).13,444 patients with ACS, of which 376 (2.8%) had concurrent VA, survived to hospital discharge and were followed up for a median of 3.42 years. Patients with VA or CA at index presentation had significantly increased risks of subsequent VA during follow-up (VA group: adjusted HR 4.15, 95% CI 2.42-7.09, CA group: adjusted HR 2.60 95% CI 1.23-5.48). Patients who suffered a CA in the context of ACS and survived to discharge also had a 36% increase in long-term mortality (adjusted hazard ratio 1.36 (95% 1.04-1.78)), though the concurrent diagnosis of VA alone during ACS did not affect all-cause mortality (adjusted HR 1.03, 95% CI 0.80-1.33). Conclusions: Patients who develop VA or CA during ACS, who survive to discharge, have increased risks of subsequent VA, while those who have CA during ACS also have an increase in long-term mortality. These individuals may represent a subgroup at greater risk of subsequent arrhythmic events due to intrinsically lower thresholds for developing VA.
AU  - Sau,A
AU  - Kaura,A
AU  - Ahmed,A
AU  - Patel,KHK
AU  - Li,X
AU  - Mulla,A
AU  - Glampson,B
AU  - Panoulas,V
AU  - Davies,J
AU  - Woods,K
AU  - Gautama,S
AU  - Shah,AD
AU  - Elliott,P
AU  - Hemingway,H
AU  - Williams,B
AU  - Asselbergs,FW
AU  - Melikian,N
AU  - Peters,NS
AU  - Shah,AM
AU  - Perera,D
AU  - Kharbanda,R
AU  - Patel,RS
AU  - Channon,KM
AU  - Mayet,J
AU  - Ng,FS
DO  - 10.1161/JAHA.121.024260
EP  - 19
PY  - 2022///
SN  - 2047-9980
SP  - 1
TI  - Prognostic significance of ventricular arrhythmias in 13444 patients with acute coronary syndrome: a retrospective cohort study based on routine clinical data (NIHR Health Informatics Collaborative VA-ACS Study)
T2  - Journal of the American Heart Association
UR  - http://dx.doi.org/10.1161/JAHA.121.024260
UR  - https://www.ahajournals.org/doi/10.1161/JAHA.121.024260
UR  - http://hdl.handle.net/10044/1/94249
VL  - 11
ER  -
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