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@article{Borgas:2021:10.5306/wjco.v12.i6.482,
author = {Borgas, P and Gonzalez, G and Veselkov, K and Mirnezami, R},
doi = {10.5306/wjco.v12.i6.482},
journal = {World Journal of Clinical Oncology},
pages = {482--499},
title = {Phytochemically rich dietary components and the risk of colorectal cancer: A systematic review and meta-analysis of observational studies},
url = {http://dx.doi.org/10.5306/wjco.v12.i6.482},
volume = {12},
year = {2021}
}

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TY  - JOUR
AB  - BACKGROUNDPersonalized nutrition and protective diets and lifestyles represent a key cancer research priority. The association between consumption of specific dietary components and colorectal cancer (CRC) incidence has been evaluated by a number of population-based studies, which have identified certain food items as having protective potential, though the findings have been inconsistent. Herein we present a systematic review and meta-analysis on the potential protective role of five common phytochemically rich dietary components (nuts, cruciferous vegetables, citrus fruits, garlic and tomatoes) in reducing CRC risk.AIMTo investigate the independent impact of increased intake of specific dietary constituents on CRC risk in the general population.METHODSMedline and Embase were systematically searched, from time of database inception to January 31, 2020, for observational studies reporting CRC incidence relative to intake of one or more of nuts, cruciferous vegetables, citrus fruits, garlic and/or tomatoes in the general population. Data were extracted by two independent reviewers and analyzed in accordance with the Meta-analysis of Observational Studies in Epidemiology (MOOSE) and Preferred Reporting Items for Systematic Review and Meta-analysis (PRISMA) reporting guidelines and according to predefined inclusion/exclusion criteria. Effect sizes of studies were pooled using a random-effects model.RESULTSForty-six studies were identified. CRC risk was significantly reduced in patients with higher vs lower consumption of cruciferous vegetables [odds ratio (OR) = 0.90; 95% confidence interval (CI): 0.85-0.95; P < 0.005], citrus fruits (OR = 0.90; 95%CI: 0.84-0.96; P < 0.005), garlic (OR = 0.83; 95%CI: 0.76-0.91; P < 0.005) and tomatoes (OR = 0.89; 95%CI: 0.84-0.95; P < 0.005). Subgroup analysis showed that this association sustained when looking at case-control studies alone, for all of these four food items, but no significant difference was found in analys
AU  - Borgas,P
AU  - Gonzalez,G
AU  - Veselkov,K
AU  - Mirnezami,R
DO  - 10.5306/wjco.v12.i6.482
EP  - 499
PY  - 2021///
SN  - 2218-4333
SP  - 482
TI  - Phytochemically rich dietary components and the risk of colorectal cancer: A systematic review and meta-analysis of observational studies
T2  - World Journal of Clinical Oncology
UR  - http://dx.doi.org/10.5306/wjco.v12.i6.482
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000668832200007&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://www.wjgnet.com/2218-4333/full/v12/i6/482.htm
UR  - http://hdl.handle.net/10044/1/90955
VL  - 12
ER  -

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