Imperial College London

DrKonstantinosBeis

Faculty of Natural SciencesDepartment of Life Sciences

Reader in Membrane Protein Structural Biology
 
 
 
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Contact

 

+44 (0)1235 567 809konstantinos.beis Website

 
 
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Location

 

1.18Diamond Light Source LtdHarwell Science and Innovation Campus

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Summary

 

Summary

MEMBRANE PROTEIN STRUCTURAL BIOLOGY

The lab is based at the Research Complex at Harwell, Oxfordshire (https://www.rc-harwell.ac.uk/research-groups/beis-group/).

Membrane proteins represent around 30% of the proteomes of most organisms and more than 40% of drug targets and yet few structures of these molecules have been solved by x-ray crystallography. Drug resistance of bacterial pathogens is a rising crisis. Bacterial membrane proteins are essential for resistance since they are involved in the export of the drugs from the cell. My group is interested to determine the structure and function of these proteins in order to elucidate the molecular mechanism of drug resistance.Clinical isolate OmpK36 from ST258

The lab is also interested to exploit novel antibacterials as treatments for bacterial infections by understanding how bacteria secrete antibacterial peptides and hijack membrane transporters of other bacteria to inhibit their growth under nutrient starvation.

We are also investigating the mechanism and dynamics of ABC transporters by employing a multidisplinary approach of protein crystallography, transport assays and biophysical methods such as PELDOR/EPR and smFRET.

ABC dynamics


Publications

Journals

Mathavan I, Liu LJ, Robinson SW, et al., 2022, Identification of inhibitors of the Schistosoma mansoni VKR2 kinase domain, Acs Medicinal Chemistry Letters, Vol:13, ISSN:1948-5875, Pages:1715-1722

Wong J, David S, Sanchez Garrido J, et al., 2022, Recurrent emergence of Klebsiella pneumoniae carbapenem resistance mediated by an inhibitory ompK36 mRNA secondary structure, Proceedings of the National Academy of Sciences of Usa, Vol:119, ISSN:0027-8424, Pages:1-12

David S, Wong JLC, Sanchez-Garrido J, et al., 2022, Widespread emergence of OmpK36 loop 3 insertions among multidrug-resistant clones of Klebsiella pneumoniae., Plos Pathogens, Vol:18, ISSN:1553-7366, Pages:1-23

Low WW, Wong J, Beltran L, et al., 2022, Mating pair stabilization mediates bacterial conjugation species specificity, Nature Microbiology, Vol:7, ISSN:2058-5276, Pages:1016-1027

Conference

Beltran L, Seddon C, Frankel G, et al., 2022, Stabilizing bacterial conjugation via conjugation junction proteins, CELL PRESS, Pages:462A-462A, ISSN:0006-3495

More Publications