Imperial College London
Alternate

Professor Koon-Yang Lee

Faculty of Engineering, Department of Aeronautics

Professor in Polymer Engineering
 
 
 
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Contact

 

+44 (0)20 7594 5150koonyang.lee

 
 
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Location

 

325City and Guilds BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Caro-Astorga:2021:10.1038/s41467-021-25350-8,
author = {Caro-Astorga, J and Walker, KT and Herrera, N and Lee, K-Y and Ellis, T},
doi = {10.1038/s41467-021-25350-8},
journal = {Nature Communications},
pages = {1--9},
title = {Bacterial cellulose spheroids as building blocks for 3D and patterned living materials and for regeneration.},
url = {http://dx.doi.org/10.1038/s41467-021-25350-8},
volume = {12},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Engineered living materials (ELMs) based on bacterial cellulose (BC) offer a promising avenue for cheap-to-produce materials that can be programmed with genetically encoded functionalities. Here we explore how ELMs can be fabricated in a modular fashion from millimetre-scale biofilm spheroids grown from shaking cultures of Komagataeibacter rhaeticus. Here we define a reproducible protocol to produce BC spheroids with the high yield bacterial cellulose producer K. rhaeticus and demonstrate for the first time their potential for their use as building blocks to grow ELMs in 3D shapes. Using genetically engineered K. rhaeticus, we produce functionalized BC spheroids and use these to make and grow patterned BC-based ELMs that signal within a material and can sense and report on chemical inputs. We also investigate the use of BC spheroids as a method to regenerate damaged BC materials and as a way to fuse together smaller material sections of cellulose and synthetic materials into a larger piece. This work improves our understanding of BC spheroid formation and showcases their great potential for fabricating, patterning and repairing ELMs based on the promising biomaterial of bacterial cellulose.
AU  - Caro-Astorga,J
AU  - Walker,KT
AU  - Herrera,N
AU  - Lee,K-Y
AU  - Ellis,T
DO  - 10.1038/s41467-021-25350-8
EP  - 9
PY  - 2021///
SN  - 2041-1723
SP  - 1
TI  - Bacterial cellulose spheroids as building blocks for 3D and patterned living materials and for regeneration.
T2  - Nature Communications
UR  - http://dx.doi.org/10.1038/s41467-021-25350-8
UR  - https://www.ncbi.nlm.nih.gov/pubmed/34413311
UR  - https://www.nature.com/articles/s41467-021-25350-8
UR  - http://hdl.handle.net/10044/1/91263
VL  - 12
ER  -
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