Imperial College London

MrsLeilaAbar

Faculty of MedicineSchool of Public Health

Research Assistant in Nutrition
 
 
 
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Contact

 

+44 (0)20 7594 2786l.abar

 
 
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Location

 

Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Vingeliene:2016:10.1007/s10552-016-0755-0,
author = {Vingeliene, S and Chan, DS and Aune, D and Vieira, AR and Polemiti, E and Stevens, C and Abar, L and Rosenblatt, DN and Greenwood, DC and Norat, T},
doi = {10.1007/s10552-016-0755-0},
journal = {Cancer Causes & Control},
pages = {837--851},
title = {An update of the WCRF/AICR systematic literature review on esophageal and gastric cancers and citrus fruits intake.},
url = {http://dx.doi.org/10.1007/s10552-016-0755-0},
volume = {27},
year = {2016}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - PURPOSE: The 2007 World Cancer Research Fund/American Institute for Cancer Research expert report concluded that foods containing vitamin C probably protect against esophageal cancer and fruits probably protect against gastric cancer. Most of the previous evidence was from case-control studies, which may be affected by recall and selection biases. More recently, several cohort studies have examined these associations. We conducted a systematic literature review of prospective studies on citrus fruits intake and risk of esophageal and gastric cancers. METHODS: PubMed was searched for studies published until 1 March 2016. We calculated summary relative risks and 95 % confidence intervals (95 % CI) using random-effects models. RESULTS: With each 100 g/day increase of citrus fruits intake, a marginally significant decreased risk of esophageal cancer was observed (summary RR 0.86, 95 % CI 0.74-1.00, 1,057 cases, six studies). The associations were similar for squamous cell carcinoma (RR 0.87, 95 % CI 0.69-1.08, three studies) and esophageal adenocarcinoma (RR 0.93, 95 % CI 0.78-1.11, three studies). For gastric cancer, the nonsignificant inverse association was observed for gastric cardia cancer (RR 0.75, 95 % CI 0.55-1.01, three studies), but not for gastric non-cardia cancer (RR 1.02, 95 % CI 0.90-1.16, four studies). Consistent summary inverse associations were observed when comparing the highest with lowest intake, with statistically significant associations for esophageal (RR 0.77, 95 % CI 0.64-0.91, seven studies) and gastric cardia cancers (RR 0.62, 95 % CI 0.39-0.99, three studies). CONCLUSIONS: Citrus fruits may decrease the risk of esophageal and gastric cardia cancers, but further studies are needed.
AU - Vingeliene,S
AU - Chan,DS
AU - Aune,D
AU - Vieira,AR
AU - Polemiti,E
AU - Stevens,C
AU - Abar,L
AU - Rosenblatt,DN
AU - Greenwood,DC
AU - Norat,T
DO - 10.1007/s10552-016-0755-0
EP - 851
PY - 2016///
SN - 1573-7225
SP - 837
TI - An update of the WCRF/AICR systematic literature review on esophageal and gastric cancers and citrus fruits intake.
T2 - Cancer Causes & Control
UR - http://dx.doi.org/10.1007/s10552-016-0755-0
UR - http://hdl.handle.net/10044/1/34452
VL - 27
ER -