Imperial College London
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DrLukeAllsopp

Faculty of Medicine, National Heart & Lung Institute

Lecturer in Bacteriology of Chronic Respiratory Infection
 
 
 
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Contact

 

l.allsopp

 
 
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Location

 

G45Emmanuel Kaye BuildingRoyal Brompton Campus

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Summary

 

Publications

Citation

BibTex format

@article{Jones:2013:10.1371/journal.pone.0081132,
author = {Jones, C and Allsopp, L and Horlick, J and Kulasekara, H and Filloux, A},
doi = {10.1371/journal.pone.0081132},
journal = {PLoS ONE},
title = {Subinhibitory concentration of kanamycin induces the pseudomonas aeruginosa type VI secretion system},
url = {http://dx.doi.org/10.1371/journal.pone.0081132},
volume = {8},
year = {2013}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Pseudomonas aeruginosa is a Gram-negative bacterium found in natural environments including plants, soils and warm moist surfaces. This organism is also in the top ten of nosocomial pathogens, and prevalent in cystic fibrosis (CF) lung infections. The ability of P. aeruginosa to colonize a wide variety of environments in a lasting manner is associated with the formation of a resistant biofilm and the capacity to efficiently outcompete other microorganisms. Here we demonstrate that sub-inhibitory concentration of kanamycin not only induces biofilm formation but also induces expression of the type VI secretion genes in the H1-T6SS cluster. The H1-T6SS is known for its role in toxin production and bacterial competition. We show that the antibiotic induction of the H1-T6SS only occurs when a functional Gac/Rsm pathway is present. These observations may contribute to understand how P. aeruginosa responds to antibiotic producing competitors. It also suggests that improper antibiotic therapy may enhance P. aeruginosa colonization, including in the airways of CF patients.
AU  - Jones,C
AU  - Allsopp,L
AU  - Horlick,J
AU  - Kulasekara,H
AU  - Filloux,A
DO  - 10.1371/journal.pone.0081132
PY  - 2013///
SN  - 1932-6203
TI  - Subinhibitory concentration of kanamycin induces the pseudomonas aeruginosa type VI secretion system
T2  - PLoS ONE
UR  - http://dx.doi.org/10.1371/journal.pone.0081132
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000327216200117&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/65717
VL  - 8
ER  -
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