Publications
40 results found
Ayaru L, Wittmann J, MacRobert AJ, et al., 2007, Photodynamic therapy using verteporfin photosensitization in the pancreas and surrounding tissues in the Syrian golden hamster, PANCREATOLOGY, Vol: 7, Pages: 20-27, ISSN: 1424-3903
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- Citations: 42
Ayaru L, Pereira SP, Meyer T, et al., 2006, Alpha-fetoprotein specific CD4<SUP>+</SUP> T cell responses are unmasked during transarterial embolisation in hepatocellular carcinoma, Annual Meeting of the British-Society-of-Gastroenterology, Publisher: B M J PUBLISHING GROUP, Pages: A24-A24, ISSN: 0017-5749
Ayaru L, Pereira SP, Meyer T, et al., 2006, Alpha-fetoprotein specific CD4+ T cell responses are unmasked during transarterial embolisation in hepatocellular carcinoma, 41st Annual Meeting of the European-Association-for-the-Study-of-the-Liver, Publisher: ELSEVIER SCIENCE BV, Pages: S11-S11, ISSN: 0168-8278
Matull WR, Dias A, Ayaru L, et al., 2005, Biliary tract cancer: A dual tertiary centre experience in the United Kingdom, 56th Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases, Publisher: JOHN WILEY & SONS INC, Pages: 379A-379A, ISSN: 0270-9139
Pereira SP, Ayaru L, Hatfield ARW, et al., 2005, Photodynamic therapy (PDT) of malignant biliary strictures using mesotetrahydroxyphenylchlorin (mTHPC)., 41st Annual Meeting of the American-Society-of-Clinical-Oncology, Publisher: AMER SOC CLINICAL ONCOLOGY, Pages: 351S-351S, ISSN: 0732-183X
Ayaru L, Bown SG, Pereira SP, 2005, Photodynamic therapy for pancreatic and biliary tract carcinoma., Int J Gastrointest Cancer, Vol: 35, Pages: 1-13, ISSN: 1537-3649
The prognosis of patients with pancreatic and biliary tract cancer treated with conventional therapies such as stent insertion or chemotherapy is often poor, and new approaches are urgently needed. Surgery is the only curative treatment but is appropriate in less than 20% of cases, and even then it is associated with a 5-yr survival of less than 30% in selected series. Photodynamic therapy represents a novel treatment for pancreaticobiliary malignancy. It is a way of producing localized tissue necrosis with light, most conveniently from a low-power, red laser, after prior administration of a photosensitizing agent, thereby initiating a non-thermal cytotoxic effect and tissue necrosis. This review outlines the mechanisms of action of photodynamic therapy including direct cell death, vascular injury, and immune system activation, and summarizes the results of preclinical and clinical studies of photodynamic therapy for pancreaticobiliary malignancy.
Dearden JC, Ayaru L, Wong V, et al., 2004, The double duct sign, LANCET, Vol: 364, Pages: 302-302, ISSN: 0140-6736
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- Citations: 11
Ayaru L, Bown SG, Pereira SP, 2004, Photodynamic therapy for pancreatic cancer-experimental and clinical studies, Photodiagnosis and Photodynamic Therapy, Vol: 1, Pages: 145-155
Ayaru L, Russell RC, Kurzawinski TR, et al., 2003, Complications arising from self-expanding metal bile duct stent insertion before definitive histological diagnosis, Annual meeting of the British-Society-of-Gastroenterology, Publisher: BRITISH MED JOURNAL PUBL GROUP, Pages: A115-A115, ISSN: 0017-5749
Ayaru L, Russell C, Kurzawinski T, et al., 2003, Complications arising from self-expanding metal bile duct stent insertion before definitive histological diagnosis, Digestive Disease Week 2003 Meeting/104th Annual Meeting of the American-Gastroenterological-Association, Publisher: MOSBY, INC, Pages: AB190-AB190, ISSN: 0016-5107
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