Imperial College London
Alternate

DrLakshmanaAyaru

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Honorary Senior Clinical Lecturer
 
 
 
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Contact

 

l.ayaru

 
 
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Location

 

Hammersmith HospitalHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Marks:2023:10.1136/bmjgast-2022-001008,
author = {Marks, IH and Janmohamed, IK and Malas, S and Mavrou, A and Banister, T and Patel, N and Ayaru, L},
doi = {10.1136/bmjgast-2022-001008},
journal = {BMJ Open Gastroenterology},
pages = {1--9},
title = {Derivation and validation of a novel risk score to predict need for haemostatic intervention in acute upper gastrointestinal bleeding (London Haemostat Score)},
url = {http://dx.doi.org/10.1136/bmjgast-2022-001008},
volume = {10},
year = {2023}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Background: Acute Upper Gastrointestinal Bleeding (AUGIB) is a common medical emergency which takes up considerable healthcare resources. However, only approximately 20-30% of bleeds require urgent haemostatic intervention. Current standard of care is for all patients admitted to hospital to undergo endoscopy within 24 hours for risk stratification, but this is difficult to achieve in practice, invasive and costly. Aim To develop a novel non-endoscopic risk stratification tool for AUGIB to predict the need for haemostatic intervention by endoscopic, radiological or surgical treatments. We compared this with the Glasgow-Blatchford Score (GBS). Design: Model development was carried out using a derivation (n=466) and prospectively collected validation cohort (n=404) of patients who were admitted with AUGIB to three large hospitals in London, UK (2015-2020). Univariable and multivariable logistic regression analysis was used to identify variables that were associated with increased or decreased chances of requiring haemostatic intervention. This model was converted into a risk scoring system, the London Haemostat Score (LHS). Results: The LHS was more accurate at predicting need for haemostatic intervention than the GBS, in the derivation cohort (Area Under the Receiver Operating Curve [AUROC] 0.82; 95% Confidence Interval (CI), 0.78-0.86 vs 0.72; 95% CI, 0.67-0.77; p<0.001) and validation cohort (AUROC 0.80; 95% CI, 0.75-0.85 vs 0.72; 95% CI, 0.67-0.78; p<0.001). At cut-off scores at which LHS and GBS identified patients who required haemostatic intervention with 98% sensitivity, the specificity of the LHS was 41% vs 18% with the GBS (p<0.001).  This could translate to 32% of inpatient endoscopies for AUGIB being avoided at a cost of only a 0.5% false negative rate.Conclusions:  The London Haemostat score is accurate at predicting the need for haemostatic intervention in AUGIB and could be used identify a proportion of low-risk patients who can undergo delayed
AU  - Marks,IH
AU  - Janmohamed,IK
AU  - Malas,S
AU  - Mavrou,A
AU  - Banister,T
AU  - Patel,N
AU  - Ayaru,L
DO  - 10.1136/bmjgast-2022-001008
EP  - 9
PY  - 2023///
SN  - 2054-4774
SP  - 1
TI  - Derivation and validation of a novel risk score to predict need for haemostatic intervention in acute upper gastrointestinal bleeding (London Haemostat Score)
T2  - BMJ Open Gastroenterology
UR  - http://dx.doi.org/10.1136/bmjgast-2022-001008
UR  - https://bmjopengastro.bmj.com/content/10/1/e001008
UR  - http://hdl.handle.net/10044/1/103157
VL  - 10
ER  -
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