Imperial College London
Alternate

DrLakshmanaAyaru

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Honorary Senior Clinical Lecturer
 
 
 
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Contact

 

l.ayaru

 
 
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Location

 

Hammersmith HospitalHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Coda:2014:10.1364/BOE.5.000515,
author = {Coda, S and Thompson, AJ and Kennedy, GT and Roche, KL and Ayaru, L and Bansi, DS and Stamp, GW and Thillainayagam, AV and French, PMW and Dunsby, C},
doi = {10.1364/BOE.5.000515},
journal = {Biomedical Optics Express},
pages = {515--538},
title = {Fluorescence lifetime spectroscopy of tissue autofluorescence in normal and diseased colon measured ex vivo using a fiber-optic probe},
url = {http://dx.doi.org/10.1364/BOE.5.000515},
volume = {5},
year = {2014}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - We present an ex vivo study of temporally and spectrally resolved autofluorescence in a total of 47 endoscopic excision biopsy/resection specimens from colon, using pulsed excitation laser sources operating at wavelengths of 375 nm and 435 nm. A paired analysis of normal and neoplastic (adenomatous polyp) tissue specimens obtained from the same patient yielded a significant difference in the mean spectrally averaged autofluorescence lifetime −570 ± 740 ps (p = 0.021, n = 12). We also investigated the fluorescence signature of non-neoplastic polyps (n = 6) and inflammatory bowel disease (n = 4) compared to normal tissue in a small number of specimens.
AU  - Coda,S
AU  - Thompson,AJ
AU  - Kennedy,GT
AU  - Roche,KL
AU  - Ayaru,L
AU  - Bansi,DS
AU  - Stamp,GW
AU  - Thillainayagam,AV
AU  - French,PMW
AU  - Dunsby,C
DO  - 10.1364/BOE.5.000515
EP  - 538
PY  - 2014///
SN  - 2156-7085
SP  - 515
TI  - Fluorescence lifetime spectroscopy of tissue autofluorescence in normal and diseased colon measured ex vivo using a fiber-optic probe
T2  - Biomedical Optics Express
UR  - http://dx.doi.org/10.1364/BOE.5.000515
UR  - http://www.imperial.ac.uk/AP/faces/pages/read/Home.jsp?person=s.coda&_adf.ctrl-state=dbvv3e7m3_3&_afrRedirect=4851527184107293
UR  - http://www.opticsinfobase.org/boe/fulltext.cfm?uri=boe-5-2-515&id=277033
UR  - http://hdl.handle.net/10044/1/12890
VL  - 5
ER  -
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