Imperial College London

Professor Lars Bertram

Faculty of MedicineSchool of Public Health

Visiting Reader
 
 
 
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l.bertram

 
 
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Charing Cross HospitalCharing Cross Campus

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Summary

 

Publications

Publication Type
Year
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225 results found

Wagner M, Lorenz G, Volk AE, Brunet T, Edbauer D, Berutti R, Zhao C, Anderl-Straub S, Bertram L, Danek A, Deschauer M, Dill V, Fassbender K, Fliessbach K, Goetze KS, Jahn H, Kornhuber J, Landwehrmeyer B, Lauer M, Obrig H, Prudlo J, Schneider A, Schroeter ML, Uttner I, Vukovich R, Wiltfang J, Winkler AS, Zhou Q, Ludolph AC, Oexle K, Otto M, Diehl-Schmid J, Winkelmann Jet al., 2021, Clinico-genetic findings in 509 frontotemporal dementia patients, MOLECULAR PSYCHIATRY, ISSN: 1359-4184

Journal article

Kusters CDJ, Paul KC, Folle AD, Keener AM, Bronstein JM, Bertram L, Hansen J, Horvath S, Sinsheimer JS, Lill CM, Ritz BRet al., 2021, Increased Menopausal Age Reduces the Risk of Parkinson's Disease: A Mendelian Randomization Approach, MOVEMENT DISORDERS, Vol: 36, Pages: 2264-2272, ISSN: 0885-3185

Journal article

Shi L, Buckley NJJ, Bos I, Engelborghs S, Sleegers K, Frisoni GB, Wallin A, Lleo A, Popp J, Martinez-Lage P, Legido-Quigley C, Barkhof F, Zetterberg H, Visser PJ, Bertram L, Lovestone S, Nevado-Holgado AJet al., 2021, Plasma Proteomic Biomarkers Relating to Alzheimer's Disease: A Meta-Analysis Based on Our Own Studies, FRONTIERS IN AGING NEUROSCIENCE, Vol: 13, ISSN: 1663-4365

Journal article

Hong S, Dobricic V, Ohlei O, Bos I, Vos SJB, Prokopenko D, Tijms BM, Andreasson U, Blennow K, Vandenberghe R, Gabel S, Scheltens P, Teunissen CE, Engelborghs S, Frisoni G, Blin O, Richardson JC, Bordet R, Lleo A, Alcolea D, Popp J, Clark C, Peyratout G, Martinez-Lage P, Tainta M, Dobson RJB, Legido-Quigley C, Sleegers K, Van Broeckhoven C, Tanzi RE, ten Kate M, Wittig M, Franke A, Lill CM, Barkhof F, Lovestone S, Streffer J, Zetterberg H, Visser PJ, Bertram Let al., 2021, TMEM106B and CPOX are genetic determinants of cerebrospinal fluid Alzheimer's disease biomarker levels, ALZHEIMERS & DEMENTIA, Vol: 17, Pages: 1628-1640, ISSN: 1552-5260

Journal article

Nyberg L, Magnussen F, Lundquist A, Baare W, Bartres-Faz D, Bertram L, Boraxbekk CJ, Brandmaier AM, Drevon CA, Ebmeier K, Ghisletta P, Henson RN, Junque C, Kievit R, Kleemeyer M, Knights E, Kuhn S, Lindenberger U, Penninx BWJH, Pudas S, Sorensen O, Vaque-Alcazar L, Walhovd KB, Fjell AMet al., 2021, Educational attainment does not influence brain aging, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 118, ISSN: 0027-8424

Journal article

Kronenberg G, Gertz K, Schoener J, Bertram L, Liman T, Steinhagen-Thiessen E, Demuth I, Endres M, Hellweg Ret al., 2021, BDNF serum concentrations in 2053 participants of the Berlin Aging Study II, NEUROBIOLOGY OF AGING, Vol: 101, Pages: 221-223, ISSN: 0197-4580

Journal article

Grydeland H, Sederevičius D, Wang Y, Bartrés-Faz D, Bertram L, Dobricic V, Düzel S, Ebmeier KP, Lindenberger U, Nyberg L, Pudas S, Sexton CE, Solé-Padullés C, Sørensen Ø, Walhovd KB, Fjell AMet al., 2021, Self-Reported Sleep Relates to Microstructural Hippocampal Decline in β-Amyloid Positive Adults Beyond Genetic Risk., Sleep

STUDY OBJECTIVES: A critical role linking sleep with memory decay and β-amyloid (Aβ) accumulation, two markers of Alzheimer's disease (AD) pathology, may be played by hippocampal integrity. We tested the hypotheses that worse self-reported sleep relates to decline in memory and intra-hippocampal microstructure, including in the presence of Aβ. METHODS: Two-hundred and forty-three cognitively healthy participants, aged 19-81 years, completed the Pittsburgh Sleep Quality Index once, and 2 diffusion tensor imaging sessions, on average 3 years apart, allowing measures of decline in intra-hippocampal microstructure as indexed by increased mean diffusivity. We measured memory decay at each imaging session using verbal delayed recall. One session of positron emission tomography, in 108 participants above 44 years of age, yielded 23 Aβ positive. Genotyping enabled control for APOE ε4 status, and polygenic scores for sleep and AD, respectively. RESULTS: Worse global sleep quality and sleep efficiency related to more rapid reduction of hippocampal microstructure over time. Focusing on efficiency (the percentage of time in bed at night spent asleep), the relation was stronger in presence of Aβ accumulation, and hippocampal integrity decline mediated the relation with memory decay. The results were not explained by genetic risk for sleep efficiency or AD. CONCLUSIONS: Worse sleep efficiency related to decline in hippocampal microstructure, especially in the presence of Aβ accumulation, and Aβ might link poor sleep and memory decay. As genetic risk did not account for the associations, poor sleep efficiency might constitute a risk marker for AD, although the driving causal mechanisms remain unknown.

Journal article

Prokopenko D, Morgan SL, Mullin K, Hofmann O, Chapman B, Kirchner R, Amberkar S, Wohlers I, Lange C, Hide W, Bertram L, Tanzi REet al., 2021, Whole-genome sequencing reveals new Alzheimer's disease-associated rare variants in loci related to synaptic function and neuronal development, ALZHEIMERS & DEMENTIA, Vol: 17, Pages: 1509-1527, ISSN: 1552-5260

Journal article

Shi L, Winchester LM, Westwood S, Baird AL, Anand SN, Buckley NJ, Hye A, Ashton NJ, Bos I, Vos SJB, ten Kate M, Scheltens P, Teunissen CE, Vandenberghe R, Gabel S, Meersmans K, Engelborghs S, De Roeck EE, Sleegers K, Frisoni GB, Blin O, Richardson JC, Bordet R, Molinuevo JL, Rami L, Wallin A, Kettunen P, Tsolaki M, Verhey F, Lleo A, Sala I, Popp J, Peyratout G, Martinez-Lage P, Tainta M, Johannsen P, Freund-Levi Y, Froeich L, Dobricic V, Legido-Quigley C, Barkhof F, Andreasson U, Blennow K, Zetterberg H, Streffer J, Lill CM, Bertram L, Visser PJ, Kolb HC, Narayan VA, Lovestone S, Nevado-Holgado AJet al., 2021, Replication study of plasma proteins relating to Alzheimer's pathology, ALZHEIMERS & DEMENTIA, Vol: 17, Pages: 1452-1464, ISSN: 1552-5260

Journal article

Jones G, Trajanoska K, Santanasto AJ, Stringa N, Kuo C-L, Atkins JL, Lewis JR, Duong T, Hong S, Biggs ML, Luan J, Sarnowski C, Lunetta KL, Tanaka T, Wojczynski MK, Cvejkus R, Nethander M, Ghasemi S, Yang J, Zillikens MC, Walter S, Sicinski K, Kague E, Ackert-Bicknell CL, Arking DE, Windham BG, Boerwinkle E, Grove ML, Graff M, Spira D, Demuth I, van der Velde N, de Groot LCPGM, Psaty BM, Odden MC, Fohner AE, Langenberg C, Wareham NJ, Bandinelli S, van Schoor NM, Huisman M, Tan Q, Zmuda J, Mellstrom D, Karlsson M, Bennett DA, Buchman AS, De Jager PL, Uitterlinden AG, Voelker U, Kocher T, Teumer A, Rodriguez-Manas L, Garcia FJ, Carnicero JA, Herd P, Bertram L, Ohlsson C, Murabito JM, Melzer D, Kuchel GA, Ferrucci L, Karasik D, Rivadeneira F, Kiel DP, Pilling LCet al., 2021, Genome-wide meta-analysis of muscle weakness identifies 15 susceptibility loci in older men and women, NATURE COMMUNICATIONS, Vol: 12, ISSN: 2041-1723

Journal article

Demuth I, Banszerus V, Drewelies J, Duezel S, Seeland U, Spira D, Tse E, Braun J, Steinhagen-Thiessen E, Bertram L, Thiel A, Lindenberger U, Regitz-Zagrosek V, Gerstorf Det al., 2021, Cohort profile: follow-up of a Berlin Aging Study II (BASE-II) subsample as part of the GendAge study, BMJ OPEN, Vol: 11, ISSN: 2044-6055

Journal article

Hong S, Prokopenko D, Dobricic V, Kilpert F, Bos I, Vos SJB, Tijms BM, Andreasson U, Blennow K, Vandenberghe R, Cleynen I, Gabel S, Schaeverbeke J, Scheltens P, Teunissen CE, Niemantsverdriet E, Engelborghs S, Frisoni G, Blin O, Richardson JC, Bordet R, Molinuevo JL, Rami L, Kettunen P, Wallin A, Lleo A, Sala I, Popp J, Peyratout G, Martinez-Lage P, Tainta M, Dobson RJB, Legido-Quigley C, Sleegers K, Van Broeckhoven C, ten Kate M, Barkhof F, Zetterberg H, Lovestone S, Streffer J, Wittig M, Franke A, Tanzi RE, Visser PJ, Bertram Let al., 2020, Genome-wide association study of Alzheimer's disease CSF biomarkers in the EMIF-AD Multimodal Biomarker Discovery dataset, TRANSLATIONAL PSYCHIATRY, Vol: 10, ISSN: 2158-3188

Journal article

Tijms BM, Gobom J, Reus L, Jansen I, Hong S, Dobricic V, Kilpert F, ten Kate M, Barkhof F, Tsolaki M, Verhey FRJ, Popp J, Martinez-Lage P, Vandenberghe R, Lle A, Molinuevo JL, Engelborghs S, Bertram L, Lovestone S, Streffer J, Vos S, Bos I, Blennow K, Scheltens P, Teunissen CE, Zetterberg H, Visser PJet al., 2020, Pathophysiological subtypes of Alzheimer's disease based on cerebrospinal fluid proteomics, BRAIN, Vol: 143, Pages: 3776-3792, ISSN: 0006-8950

Journal article

Walhovd KB, Fjell AM, Sorensen O, Mowinckel AM, Reinbold CS, Idland A-V, Watne LO, Franke A, Dobricic V, Kilpert F, Bertram L, Wang Yet al., 2020, Genetic risk for Alzheimer disease predicts hippocampal volume through the human lifespan, NEUROLOGY-GENETICS, Vol: 6, ISSN: 2376-7839

Journal article

Kusters CDJ, Paul KC, Folle AD, Keener AM, Bronstein JM, Dobricic V, Tysnes O-B, Bertram L, Alves G, Sinsheimer JS, Lill CM, Maple-Grodem J, Ritz BRet al., 2020, Genetic risk scores and hallucinations in patients with Parkinson disease, NEUROLOGY-GENETICS, Vol: 6, ISSN: 2376-7839

Journal article

Rieck L, Bardey F, Grenkowitz T, Bertram L, Helmuth J, Mischung C, Spranger J, Steinhagen-Thiessen E, Bobbert T, Kassner U, Demuth Iet al., 2020, Mutation spectrum and polygenic score in German patients with familial hypercholesterolemia, CLINICAL GENETICS, Vol: 98, Pages: 457-467, ISSN: 0009-9163

Journal article

Bertram L, Tanzi RE, 2020, Genomic mechanisms in Alzheimer's disease, BRAIN PATHOLOGY, Vol: 30, Pages: 966-977, ISSN: 1015-6305

Journal article

Roehr F, Bucholtz N, Toepfer S, Norman K, Spira D, Steinhagen-Thiessen E, Lill CM, Bertram L, Demuth I, Buchmann N, Duezel Set al., 2020, Relationship between Lipoprotein (a) and cognitive function - Results from the Berlin Aging Study II, SCIENTIFIC REPORTS, Vol: 10, ISSN: 2045-2322

Journal article

Konijnenberg E, Tijms BM, Gobom J, Dobricic V, Bos I, Vos S, Tsolaki M, Verhey F, Popp J, Martinez-Lage P, Vandenberghe R, Lleo A, Froelich L, Lovestone S, Streffer J, Bertram L, Blennow K, Teunissen CE, Veerhuis R, Smit AB, Scheltens P, Zetterberg H, Visser PJet al., 2020, APOE epsilon 4 genotype-dependent cerebrospinal fluid proteomic signatures in Alzheimer's disease, ALZHEIMERS RESEARCH & THERAPY, Vol: 12

Journal article

Fjell AM, Sederevicius D, Sneve MH, De Lange A-MG, Brathen AC, Idland A-V, Watne LO, Wang Y, Reinbold C, Dobricic V, Kilpert F, Blennow K, Zetterbergj H, Hong S, Bertram L, Walhovd KBet al., 2020, Self-reported Sleep Problems Related to Amyloid Deposition in Cortical Regions with High HOMER1 Gene Expression, CEREBRAL CORTEX, Vol: 30, Pages: 2144-2156, ISSN: 1047-3211

Journal article

Prokopenko D, Hecker J, Kirchner R, Chapman BA, Hoffman O, Mullin K, Hide W, Bertram L, Laird N, DeMeo DL, Lange C, Tanzi REet al., 2020, Identification of Novel Alzheimer's Disease Loci Using Sex-Specific Family-Based Association Analysis of Whole-Genome Sequence Data, SCIENTIFIC REPORTS, Vol: 10, ISSN: 2045-2322

Journal article

Wohlers I, Schulz C, Kilpert F, Bertram Let al., 2020, Alzheimer's disease risk SNPs show no strong effect on miRNA expression in human lymphoblastoid cell lines, NEUROBIOLOGY OF AGING, Vol: 86, ISSN: 0197-4580

Journal article

Shi L, Winchester LM, Liu BY, Killick R, Ribe EM, Westwood S, Baird AL, Buckley NJ, Hong S, Dobricic V, Kilpert F, Franke A, Kiddle S, Sattlecker M, Dobson R, Cuadrado A, Hye A, Ashton NJ, Morgan AR, Bos I, Vos SJB, ten Kate M, Scheltens P, Vandenberghe R, Gabel S, Meersmans K, Engelborghs S, De Roeck EE, Sleegers K, Frisoni GB, Blin O, Richardson JC, Bordet R, Molinuevo JL, Rami L, Wallin A, Kettunen P, Tsolaki M, Verhey F, Lleo A, Alcolea D, Popp J, Peyratout G, Martinez-Lage P, Tainta M, Johannsen P, Teunissen CE, Freund-Levi Y, Frolich L, Legido-Quigley C, Barkhof F, Blennow K, Rasmussen KL, Nordestgaard BG, Frikke-Schmidt R, Nielsen SF, Soininen H, Vellas B, Kloszewska I, Mecocci P, Zetterberg H, Morgan BP, Streffer J, Visser PJ, Bertram L, Nevado-Holgado AJ, Lovestone Set al., 2020, Dickkopf-1 Overexpression in vitro Nominates Candidate Blood Biomarkers Relating to Alzheimer's Disease Pathology, JOURNAL OF ALZHEIMERS DISEASE, Vol: 77, Pages: 1353-1368, ISSN: 1387-2877

Journal article

Westwood S, Baird AL, Anand SN, Nevado-Holgado AJ, Kormilitzin A, Shi L, Hye A, Ashton NJ, Morgan AR, Bos I, Vos SJB, Baker S, Buckley NJ, Ten Kate M, Scheltens P, Teunissen CE, Vandenberghe R, Gabel S, Meersmans K, Engelborghs S, De Roeck EE, Sleegers K, Frisoni GB, Blin O, Richardson JC, Bordet R, Molinuevo JL, Rami L, Wallin A, Kettunen P, Tsolaki M, Verhey F, Lleo A, Sala I, Popp J, Peyratout G, Martinez-Lage P, Tainta M, Johannsen P, Freund-Levi Y, Froelich L, Dobricic V, Legido-Quigley C, Bertram L, Barkhof F, Zetterberg H, Morgan BP, Streffer J, Visser PJ, Lovestone Set al., 2020, Validation of Plasma Proteomic Biomarkers Relating to Brain Amyloid Burden in the EMIF-Alzheimer's Disease Multimodal Biomarker Discovery Cohort, JOURNAL OF ALZHEIMERS DISEASE, Vol: 74, Pages: 213-225, ISSN: 1387-2877

Journal article

Shi L, Westwood S, Baird AL, Winchester L, Dobricic V, Kilpert F, Hong S, Franke A, Hye A, Ashton NJ, Morgan AR, Bos I, Vos SJB, Buckley NJ, ten Kate M, Scheltens P, Vandenberghe R, Gabel S, Meersmans K, Engelborghs S, De Roeck EE, Sleegers K, Frisoni GB, Blin O, Richardson JC, Bordet R, Molinuevo JL, Rami L, Wallin A, Kettunen P, Tsolaki M, Verhey F, Lleo A, Alcolea D, Popp J, Peyratout G, Martinez-Lage P, Tainta M, Johannsen P, Teunissen CE, Freund-Levi Y, Froelich L, Legido-Quigley C, Barkhof F, Blennow K, Zetterberg H, Baker S, Morgan BP, Streffer J, Visser PJ, Bertram L, Lovestone S, Nevado-Holgado AJet al., 2019, Discovery and validation of plasma proteomic biomarkers relating to brain amyloid burden by SOMAscan assay, ALZHEIMERS & DEMENTIA, Vol: 15, Pages: 1478-1488, ISSN: 1552-5260

Journal article

Takousis P, Sadlon A, Schulz J, Wohlers I, Dobricic V, Middleton L, Lill CM, Perneczky R, Bertram Let al., 2019, Differential expression of microRNAs in Alzheimer's disease brain, blood, and cerebrospinal fluid, Alzheimers & Dementia, Vol: 15, Pages: 1468-1477, ISSN: 1552-5260

INTRODUCTION: Several microRNAs (miRNAs) have been implicated in Alzheimer's disease pathogenesis, but the evidence from individual case-control studies remains inconclusive. METHODS: A systematic literature review was performed, followed by standardized multistage data extraction, quality control, and meta-analyses on eligible data for brain, blood, and cerebrospinal fluid specimens. Results were compared with miRNAs reported in the abstracts of eligible studies or recent qualitative reviews to assess novelty. RESULTS: Data from 147 independent data sets across 107 publications were quantitatively assessed in 461 meta-analyses. Twenty-five, five, and 32 miRNAs showed studywide significant differential expression (α < 1·08 × 10-4) in brain, cerebrospinal fluid, and blood-derived specimens, respectively, with 5 miRNAs showing differential expression in both brain and blood. Of these 57 miRNAs, 13 had not been reported in the abstracts of previous original or review articles. DISCUSSION: Our systematic assessment of differential miRNA expression is the first of its kind in Alzheimer's disease and highlights several miRNAs of potential relevance.

Journal article

Schmidt AF, Holmes MV, Preiss D, Swerdlow DI, Denaxas S, Fatemifar G, Faraway R, Finan C, Valentine D, Fairhurst-Hunter Z, Hartwig FP, Horta BL, Hypponen E, Power C, Moldovan M, van Iperen E, Hovingh K, Demuth I, Norman K, Steinhagen-Thiessen E, Demuth J, Bertram L, Lill CM, Coassin S, Willeit J, Kiechl S, Willeit K, Mason D, Wright J, Morris R, Wanamethee G, Whincup P, Ben-Shlomo Y, McLachlan S, Price JF, Kivimaki M, Welch C, Sanchez-Galvez A, Marques-Vidal P, Nicolaides A, Panayiotou AG, Onland-Moret NC, van der Schouw YT, Matullo G, Fiorito G, Guarrera S, Sacerdote C, Wareham NJ, Langenberg C, Scott RA, Luan J, Bobak M, Malyutina S, Pająk A, Kubinova R, Tamosiunas A, Pikhart H, Grarup N, Pedersen O, Hansen T, Linneberg A, Jess T, Cooper J, Humphries SE, Brilliant M, Kitchner T, Hakonarson H, Carrell DS, McCarty CA, Lester KH, Larson EB, Crosslin DR, de Andrade M, Roden DM, Denny JC, Carty C, Hancock S, Attia J, Holliday E, Scott R, Schofield P, O'Donnell M, Yusuf S, Chong M, Pare G, van der Harst P, Said MA, Eppinga RN, Verweij N, Snieder H, Lifelines Cohort authors, Christen T, Mook-Kanamori DO, ICBP Consortium, Gustafsson S, Lind L, Ingelsson E, Pazoki R, Franco O, Hofman A, Uitterlinden A, Dehghan A, Teumer A, Baumeister S, Dörr M, Lerch MM, Völker U, Völzke H, Ward J, Pell JP, Meade T, Christophersen IE, Maitland-van der Zee AH, Baranova EV, Young R, Ford I, Campbell A, Padmanabhan S, Bots ML, Grobbee DE, Froguel P, Thuillier D, Roussel R, Bonnefond A, Cariou B, Smart M, Bao Y, Kumari M, Mahajan A, Hopewell JC, Seshadri S, METASTROKE Consortium of the ISGC, Dale C, Costa RPE, Ridker PM, Chasman DI, Reiner AP, Ritchie MD, Lange LA, Cornish AJ, Dobbins SE, Hemminki K, Kinnersley B, Sanson M, Labreche K, Simon M, Bondy M, Law P, Speedy H, Allan J, Li N, Went M, Weinhold N, Morgan G, Sonneveld P, Nilsson B, Goldschmidt H, Sud A, Engert A, Hansson M, Hemingway H, Asselbergs FW, Patel RS, Keating BJ, Sattar N, Houlston R, Casas JP, Hingorani ADet al., 2019, Phenome-wide association analysis of LDL-cholesterol lowering genetic variants in PCSK9, BMC Cardiovascular Disorders, Vol: 19, ISSN: 1471-2261

BACKGROUND: We characterised the phenotypic consequence of genetic variation at the PCSK9 locus and compared findings with recent trials of pharmacological inhibitors of PCSK9. METHODS: Published and individual participant level data (300,000+ participants) were combined to construct a weighted PCSK9 gene-centric score (GS). Seventeen randomized placebo controlled PCSK9 inhibitor trials were included, providing data on 79,578 participants. Results were scaled to a one mmol/L lower LDL-C concentration. RESULTS: The PCSK9 GS (comprising 4 SNPs) associations with plasma lipid and apolipoprotein levels were consistent in direction with treatment effects. The GS odds ratio (OR) for myocardial infarction (MI) was 0.53 (95% CI 0.42; 0.68), compared to a PCSK9 inhibitor effect of 0.90 (95% CI 0.86; 0.93). For ischemic stroke ORs were 0.84 (95% CI 0.57; 1.22) for the GS, compared to 0.85 (95% CI 0.78; 0.93) in the drug trials. ORs with type 2 diabetes mellitus (T2DM) were 1.29 (95% CI 1.11; 1.50) for the GS, as compared to 1.00 (95% CI 0.96; 1.04) for incident T2DM in PCSK9 inhibitor trials. No genetic associations were observed for cancer, heart failure, atrial fibrillation, chronic obstructive pulmonary disease, or Alzheimer's disease - outcomes for which large-scale trial data were unavailable. CONCLUSIONS: Genetic variation at the PCSK9 locus recapitulates the effects of therapeutic inhibition of PCSK9 on major blood lipid fractions and MI. While indicating an increased risk of T2DM, no other possible safety concerns were shown; although precision was moderate.

Journal article

Morgan AR, Touchard S, Leckey C, O'Hagan C, Nevado-Holgado AJ, Barkhof F, Bertram L, Blin O, Bos I, Dobricic V, Engelborghs S, Frisoni G, Froelich L, Gabel S, Johannsen P, Kettunen P, Koszewska I, Legido-Quigley C, Lleo A, Martinez-Lage P, Mecocci P, Meersmans K, Luis Molinuevo J, Peyratout G, Popp J, Richardson J, Sala I, Scheltens P, Streffer J, Soininen H, Tainta-Cuezva M, Teunissen C, Tsolaki M, Vandenberghe R, Visser PJ, Vos S, Wahlund L-O, Wallin A, Westwood S, Zetterberg H, Lovestone S, Morgan BP, Bullmore ET, Bhatti J, Chamberlain SJ, Correia MM, Crofts AL, Dickinson A, Foster AC, Kitzbichler MG, Knight C, Lynall M-E, Maurice C, O'Donnell C, Pointon LJ, Hyslop PSG, Turner L, Vertes P, Widmer B, Williams GB, Morgan BP, Leckey C, Morgan AR, O'Hagan C, Touchard S, Cavanagh J, Deith C, Farmer S, McClean J, McColl A, McPherson A, Scouller P, Sutherland M, Boddeke HWGME, Richardson JC, Khan S, Murphy P, Parker CA, Patel J, Jones D, de Boer P, Kemp J, Drevets WC, Nye JS, Wittenberg G, Isaac J, Bhattacharya A, Carruthers N, Kolb H, Pariante CM, Turkheimer F, Barker GJ, Byrom H, Cash D, Cattaneo A, Gee A, Hastings C, Mariani N, McLaughlin A, Mondelli V, Nettis M, Nikkheslat N, Randall K, Sheridan H, Simmons C, Singh N, Van Loo V, Vicente-Rodriguez M, Wood TC, Worrell C, Zajkowska Z, Plath N, Egebjerg J, Eriksson H, Gastambide F, Adams KH, Jeggo R, Thomsen C, Pederson JT, Campbell B, Moller T, Nelson B, Zorn S, O'Connor J, Attenburrow MJ, Baird A, Benjamin J, Clare S, Cowen P, Huang I-SD, Hurley S, Jones H, Lovestone S, Mada F, Nevado-Holgado A, Oladejo A, Ribe E, Smith K, Vyas A, Hughes Z, Balice-Gordon R, Duerr J, Piro JR, Sporn J, Perry VH, Cleal M, Fryatt G, Gomez-Nicola D, Mancuso R, Reynolds R, Harrison NA, Cercignani M, Clarke CL, Hoskins E, Kohn C, Murray R, Wilcock L, Wlazly Det al., 2019, Inflammatory biomarkers in Alzheimer's disease plasma, ALZHEIMERS & DEMENTIA, Vol: 15, Pages: 776-787, ISSN: 1552-5260

Journal article

Kim M, Snowden S, Suvitaival T, Ali A, Merkler DJ, Ahmad T, Westwood S, Baird A, Proitsi P, Nevado-Holgado A, Hye A, Bos I, Vos S, Vandenberghe R, Teunissen C, ten Kate M, Scheltens P, Gabel S, Meersmans K, Blin O, Richardson J, De Roeck E, Sleegers K, Bordet R, Rami L, Kettunen P, Tsolaki M, Verhey F, Sala I, Lleo A, Peyratout G, Tainta M, Johannsen P, Freund-Levi Y, Frolich L, Dobricic V, Engelborghs S, Frisoni GB, Molinuevo JL, Wallin A, Popp J, Martinez-Lage P, Bertram L, Barkhof F, Ashton N, Blennow K, Zetterberg H, Streffer J, Visser PJ, Lovestone S, Legido-Quigley Cet al., 2019, Primary fatty amides in plasma associated with brain amyloid burden, hippocampal volume, and memory in the European Medical Information Framework for Alzheimer's Disease biomarker discovery cohort, ALZHEIMERS & DEMENTIA, Vol: 15, Pages: 817-827, ISSN: 1552-5260

Journal article

Schulz J, Takousis P, Wohlers I, Itua IOG, Dobricic V, Rücker G, Binder H, Middleton L, Ioannidis JPA, Perneczky R, Bertram L, Lill CMet al., 2019, Meta-analyses identify differentially expressed microRNAs in Parkinson's disease, Annals of Neurology, Vol: 85, Pages: 835-851, ISSN: 0364-5134

Objective: MicroRNA-mediated (dys)regulation of gene expression has been implicated in Parkinson's disease (PD), although results of microRNA expression studies remain inconclusive. We aimed to identify microRNAs that show consistent differential expression across all published expression studies in PD.Mathods: We performed a systematic literature search on microRNA expression studies in PD and extracted data from eligible publications. After stratification for brain, blood, and cerebrospinal fluid (CSF)-derived specimen we performed meta-analyses across microRNAs assessed in three or more independent datasets. Meta-analyses were performed using effect-size and p-value based methods, as applicable.Results: After screening 599 publications we identified 47 datasets eligible for meta-analysis. On these, we performed 160 meta-analyses on microRNAs quantified in brain (n=125), blood (n=31), or CSF samples (n=4). Twenty-one meta-analyses were performed using effect sizes. We identified 13 significantly (Bonferroni-adjusted α=3.13x10-4 ) differentially expressed microRNAs in brain (n=3) and blood (n=10) with consistent effect directions across studies. The most compelling findings were with hsa-miR-132-3p (p=6.37x10-5 ), hsa-miR-497-5p (p=1.35x10-4 ), and hsa-miR-133b (p=1.90x10-4 ) in brain, and with hsa-miR-221-3p (p=4.49x10-35 ), hsa-miR-214-3p (p=2.00x10-34 ), and hsa-miR-29c-3p (p=3.00x10-12 ) in blood. No significant signals were found in CSF. Analyses of GWAS data for target genes of brain microRNAs showed significant association (α=9.40x10-5 ) of genetic variants in nine loci.Interpretation: We identified several microRNAs that showed highly significant differential expression in PD. Future studies may assess the possible role of the identified brain miRNAs in pathogenesis and disease progression as well as the potential of the top blood microRNAs as biomarkers for diagnosis, progression or prediction of PD.

Journal article

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