Publications
61 results found
Liepe J, Taylor H, Barnes CP, et al., 2012, Calibrating spatio-temporal models of leukocyte dynamics against <i>in vivo</i> live-imaging data using approximate Bayesian computation, INTEGRATIVE BIOLOGY, Vol: 4, Pages: 335-345, ISSN: 1757-9694
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- Citations: 30
Bugeon L, Taylor HB, Progatzky F, et al., 2011, The NOTCH pathway contributes to cell fate decision in myelopoiesis, HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, Vol: 96, Pages: 1753-1760, ISSN: 0390-6078
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- Citations: 12
Le Friec G, Bugeon L, Dallman M, et al., 2011, Crosstalk between complement and notch systems is required for normal function and regulation of Th1 responses, Annual Congress of the British-Society-for-Immunology, Publisher: WILEY-BLACKWELL, Pages: 67-67, ISSN: 0019-2805
Pridgeon C, Bugeon L, Donnelly L, et al., 2011, Regulation of IL-17 in chronic inflammation in the human lung., Clin Sci (Lond), Vol: 120, Pages: 515-524
The regulation of human Th17 cell effector function by Treg cells (regulatory T-cells) is poorly understood. In the present study, we report that human Treg (CD4(+)CD25(+)) cells inhibit the proliferative response of Th17 cells but not their capacity to secrete IL (interleukin)-17. However, they could inhibit proliferation and cytokine production by Th1 and Th2 cells as determined by IFN-γ (interferon-γ) and IL-5 biosynthesis. Currently, as there is interest in the role of IL-17-producing cells and Treg cells in chronic inflammatory diseases in humans, we investigated the presence of CD4(+)CD25(+) T-cells and IL-17 in inflammation in the human lung. Transcripts for IL-17 were expressed in mononuclear cells and purified T-cells from lung tissue of patients with chronic pulmonary inflammation and, when activated, these cells secrete soluble protein. The T-cell-specific transcription factors RORCv2 (retinoic acid-related orphan receptor Cv2; for Th17) and FOXP3 (forkhead box P3; for Treg cells) were enriched in the T-cell fraction of lung mononuclear cells. Retrospective stratification of the patient cohort into those with COPD (chronic obstructive pulmonary disease) and non-COPD lung disease revealed no difference in the expression of IL-17 and IL-23 receptor between the groups. We observed that CD4(+)CD25(+) T-cells were present in comparable numbers in COPD and non-COPD lung tissue and with no correlation between the presence of CD4(+)CD25(+) T-cells and IL-17-producing cells. These results suggest that IL-17-expressing cells are present in chronically inflamed lung tissue, but there is no evidence to support this is due to the recruitment or expansion of Treg cells.
McGinty J, Taylor HB, Chen L, et al., 2011, In vivo fluorescence lifetime optical projection tomography, Biomedical Optics Express, Vol: 2, Pages: 1340-1350, ISSN: 2156-7085
We demonstrate the application of fluorescence lifetime optical projection tomography (FLIM-OPT) to in vivo imaging of lysC:GFP transgenic zebrafish embryos (Danio rerio). This method has been applied to unambiguously distinguish between the fluorescent protein (GFP) signal in myeloid cells from background autofluorescence based on the fluorescence lifetime. The combination of FLIM, an inherently ratiometric method, in conjunction with OPT results in a quantitative 3-D tomographic technique that could be used as a robust method for in vivo biological and pharmaceutical research, for example as a readout of Förster resonance energy transfer based interactions.
Le Friec G, Bugeon L, Dallman M, et al., 2010, CD46: just a Notch up your common complement regulator, Annual Congress of the British-Society-for-Immunology, Publisher: WILEY-BLACKWELL PUBLISHING, INC, Pages: 174-174, ISSN: 0019-2805
Le Friec G, Bugeon L, Dallman M, et al., 2010, CD46: Just a Notch up your common complement regulator, 23rd International National Complement Workshop, Publisher: PERGAMON-ELSEVIER SCIENCE LTD, Pages: 2229-2229, ISSN: 0161-5890
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- Citations: 3
Mollet G, Ratelade J, Boyer O, et al., 2009, Podocin Inactivation in Mature Kidneys Causes Focal Segmental Glomerulosclerosis and Nephrotic Syndrome, JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, Vol: 20, Pages: 2181-2189, ISSN: 1046-6673
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- Citations: 79
Bugeon L, Gardner LM, Rose A, et al., 2008, Cutting Edge: Notch Signaling Induces a Distinct Cytokine Profile in Dendritic Cells That Supports T Cell-Mediated Regulation and IL-2-Dependent IL-17 Production, JOURNAL OF IMMUNOLOGY, Vol: 181, Pages: 8189-8193, ISSN: 0022-1767
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- Citations: 32
Boyer O, Mollet G, Muda AO, et al., 2007, A novel mouse model of podocin inactivation in the adult mouse develops nephrotic syndrome and glomerulosclerosis, Publisher: SPRINGER, Pages: 1502-1502, ISSN: 0931-041X
Bugeon L, Wong KK, Rankin AM, et al., 2006, A negative regulatory role in mouse cardiac transplantation for a splice variant of CD80, TRANSPLANTATION, Vol: 82, Pages: 1334-1341, ISSN: 0041-1337
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- Citations: 4
Wagner KD, Wagner N, Guo JK, et al., 2006, An inducible mouse model for PAX2-dependent glomerular disease: Insights into a complex pathogenesis, CURRENT BIOLOGY, Vol: 16, Pages: 793-800, ISSN: 0960-9822
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- Citations: 34
Tolmachova T, Anders R, Abrink M, et al., 2006, Independent degeneration of photoreceptors and retinal pigment epithelium in conditional knockout mouse models of choroideremia, JOURNAL OF CLINICAL INVESTIGATION, Vol: 116, Pages: 386-394, ISSN: 0021-9738
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- Citations: 100
Holzenberger M, Tronche F, Bugeon L, et al., 2005, A french academic network for sharing transgenic materials and knowledge, TRANSGENIC RESEARCH, Vol: 14, Pages: 801-802, ISSN: 0962-8819
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- Citations: 1
Bugeon L, Rosewell I, 2003, Mouse locator-UK": a networking tool for academic transgenic research in the UK, TRANSGENIC RESEARCH, Vol: 12, Pages: 637-637, ISSN: 0962-8819
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- Citations: 3
Bugeon L, Rosewell I, 2003, "Mouse locator-UK": a networking tool for academic transgenic research in the UK., Transgenic Res, Vol: 12, ISSN: 0962-8819
Brown AE, Bugeon L, Crisanti A, et al., 2003, Stable and heritable gene silencing in the malaria vector <i>Anopheles stephensi</i> -: art. no. e85, NUCLEIC ACIDS RESEARCH, Vol: 31, ISSN: 0305-1048
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- Citations: 46
Bugeon L, Danou A, Carpentier D, et al., 2003, Inducible gene silencing in podocytes: A new tool for studying glomerular function, JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, Vol: 14, Pages: 786-791, ISSN: 1046-6673
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- Citations: 24
Bugeon L, Hargreaves REG, Crompton T, et al., 2001, Selective silencing of full-length CD80 but not IgV-CD80 leads to impaired clonal deletion of self-reactive T cells and altered regulation of immune responses, EUROPEAN JOURNAL OF IMMUNOLOGY, Vol: 31, Pages: 118-127, ISSN: 0014-2980
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- Citations: 6
Bugeon L, Dallman MJ, 2000, Costimulation of T cells, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 162, Pages: S164-S168, ISSN: 1073-449X
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- Citations: 55
Bugeon L, Syed N, Dallman MJ, 2000, A fast and efficient method for transiently transfecting ES cells: application to the development of systems for conditional gene expression, TRANSGENIC RESEARCH, Vol: 9, Pages: 229-232, ISSN: 0962-8819
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- Citations: 10
JOSIEN R, PANNETIER C, DOUILLARD P, et al., 1995, GRAFT-INFILTRATING T-HELPER CELLS, CD45RC PHENOTYPE, AND TH1/TH2-RELATED CYTOKINES IN DONOR-SPECIFIC TRANSFUSION-INDUCED TOLERANCE IN ADULT-RATS, TRANSPLANTATION, Vol: 60, Pages: 1131-1139, ISSN: 0041-1337
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- Citations: 78
CUTURI MC, JOSIEN R, CANTAROVICH D, et al., 1994, DECREASED ANTIDONOR MAJOR HISTOCOMPATIBILITY COMPLEX CLASS-I AND INCREASED CLASS-II ALLOANTIBODY RESPONSE IN ALLOGRAFT TOLERANCE IN ADULT-RATS, EUROPEAN JOURNAL OF IMMUNOLOGY, Vol: 24, Pages: 1627-1631, ISSN: 0014-2980
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- Citations: 41
PARKER KE, BUGEON L, CUTURI MC, et al., 1994, CLONING OF CDNA CODING FOR THE RAT MU-HEAVY-CHAIN CONSTANT-REGION - DIFFERENCES BETWEEN RAT ALLOTYPES, IMMUNOGENETICS, Vol: 39, Pages: 159-159, ISSN: 0093-7711
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- Citations: 5
Parker KE, Bugeon L, Cuturi MC, et al., 1994, Cloning of cDNA coding for the rat mu heavy chain constant region: differences between rat allotypes., Immunogenetics, Vol: 39, ISSN: 0093-7711
BUGEON L, CUTURI MC, PAINEAU J, et al., 1993, SIMILAR LEVELS OF GRANZYME-A AND PERFORIN MESSENGER-RNA EXPRESSION IN REJECTED AND TOLERATED HEART ALLOGRAFTS IN DONOR-SPECIFIC TOLERANCE IN RATS, TRANSPLANTATION, Vol: 56, Pages: 405-408, ISSN: 0041-1337
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- Citations: 15
BUGEON L, CUTURI MC, PAINEAU J, et al., 1993, DECREASED IFN-GAMMA AND IL-2 MESSENGER-RNA EXPRESSION IN PERIPHERAL TOLERANCE TO HEART ALLOGRAFTS WITH CONSERVED GRANZYME-A, PERFORIN, AND MHC ANTIGENS MESSENGER-RNA EXPRESSION, TRANSPLANTATION PROCEEDINGS, Vol: 25, Pages: 314-316, ISSN: 0041-1345
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- Citations: 7
BUGEON L, CUTURI MC, HALLET MM, et al., 1992, PERIPHERAL TOLERANCE OF AN ALLOGRAFT IN ADULT-RATS - CHARACTERIZATION BY LOW INTERLEUKIN-2 AND INTERFERON-GAMMA MESSENGER-RNA LEVELS AND BY STRONG ACCUMULATION OF MAJOR HISTOCOMPATIBILITY COMPLEX TRANSCRIPTS IN THE GRAFT, TRANSPLANTATION, Vol: 54, Pages: 219-225, ISSN: 0041-1337
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- Citations: 115
BLANCHO G, BUZELIN F, DANTAL J, et al., 1992, EVIDENCE THAT EARLY ACUTE-RENAL-FAILURE MAY BE MEDIATED BY CD3-CD16+ CELLS IN A KIDNEY GRAFT RECIPIENT WITH LARGE GRANULAR LYMPHOCYTE-PROLIFERATION, TRANSPLANTATION, Vol: 53, Pages: 1242-1247, ISSN: 0041-1337
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- Citations: 13
JAISSER F, BUGEON L, PRADELLES P, et al., 1991, KINETICS OF AVP-INDUCED PGE2 SYNTHESIS IN THE RABBIT CORTICAL COLLECTING TUBULE, 3RD INTERNATIONAL VASOPRESSIN CONF, Publisher: INST NATL SANTE RECHERCHE MEDICALE, Pages: 503-510
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