Imperial College London
Dr Laurence Bugeon

DrLaurenceBugeon

Faculty of Natural Sciences, Department of Life Sciences

Research Fellow
 
 
 
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Contact

 

+44 (0)20 7594 5405l.bugeon

 
 
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Location

 

Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Bottiglione:2020:10.4049/jimmunol.2000372,
author = {Bottiglione, F and Dee, CT and Lea, R and Zeef, LAH and Badrock, AP and Wane, M and Bugeon, L and Dallman, MJ and Allen, JE and Hurlstone, AFL},
doi = {10.4049/jimmunol.2000372},
journal = {Journal of Immunology},
pages = {994--1008},
title = {Zebrafish IL-4-like cytokines and IL-10 suppress inflammation but only IL-10 is essential for gill homeostasis},
url = {http://dx.doi.org/10.4049/jimmunol.2000372},
volume = {205},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Mucosal surfaces such as fish gills interface between the organism and the external environment and as such are major sites of foreign Ag encounter. In the gills, the balance between inflammatory responses to waterborne pathogens and regulatory responses toward commensal microbes is critical for effective barrier function and overall fish health. In mammals, IL-4 and IL-13 in concert with IL-10 are essential for balancing immune responses to pathogens and suppressing inflammation. Although considerable progress has been made in the field of fish immunology in recent years, whether the fish counterparts of these key mammalian cytokines perform similar roles is still an open question. In this study, we have generated IL-4/13A and IL-4/13B mutant zebrafish (Danio rerio) and, together with an existing IL-10 mutant line, characterized the consequences of loss of function of these cytokines. We demonstrate that IL-4/13A and IL-4/13B are required for the maintenance of a Th2-like phenotype in the gills and the suppression of type 1 immune responses. As in mammals, IL-10 appears to have a more striking anti-inflammatory function than IL-4–like cytokines and is essential for gill homeostasis. Thus, both IL-4/13 and IL-10 paralogs in zebrafish exhibit aspects of conserved function with their mammalian counterparts.
AU  - Bottiglione,F
AU  - Dee,CT
AU  - Lea,R
AU  - Zeef,LAH
AU  - Badrock,AP
AU  - Wane,M
AU  - Bugeon,L
AU  - Dallman,MJ
AU  - Allen,JE
AU  - Hurlstone,AFL
DO  - 10.4049/jimmunol.2000372
EP  - 1008
PY  - 2020///
SN  - 0022-1767
SP  - 994
TI  - Zebrafish IL-4-like cytokines and IL-10 suppress inflammation but only IL-10 is essential for gill homeostasis
T2  - Journal of Immunology
UR  - http://dx.doi.org/10.4049/jimmunol.2000372
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000558826900014&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://www.jimmunol.org/content/205/4/994
UR  - http://hdl.handle.net/10044/1/83214
VL  - 205
ER  -
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