Imperial College London
Alternate

ProfessorLakiBuluwela

Faculty of Medicine, Department of Surgery & Cancer

Professor of Cancer Medicine
 
 
 
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Contact

 

+44 (0)20 7594 2812l.buluwela

 
 
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Assistant

 

Mrs Maureen Francis +44 (0)20 7594 2793

 
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Location

 

133ICTEM buildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Periyasamy:2015:10.1016/j.celrep.2015.08.066,
author = {Periyasamy, M and Patel, H and Lai, C-F and Nguyen, VTM and Nevedomskaya, E and Harrod, A and Russell, R and Remenyi, J and Ochocka, AM and Thomas, RS and Fuller-Pace, F and Gyorffy, B and Caldas, C and Navaratnam, N and Carroll, JS and Zwart, W and Coombes, RC and Magnani, L and Buluwela, L and Ali, S},
doi = {10.1016/j.celrep.2015.08.066},
journal = {Cell Reports},
pages = {108--121},
title = {APOBEC3B mediated cytidine deamination is required for estrogen receptor action in breast cancer},
url = {http://dx.doi.org/10.1016/j.celrep.2015.08.066},
volume = {13},
year = {2015}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Estrogen receptor α (ERα) is the key transcriptional driver in a large proportion of breast cancers. We report that APOBEC3B (A3B) is required for regulation of gene expression by ER and acts by causing C-to-U deamination at ER binding regions. We show that these C-to-U changes lead to the generation of DNA strand breaks through activation of base excision repair (BER) and to repair by non-homologous end-joining (NHEJ) pathways. We provide evidence that transient cytidine deamination by A3B aids chromatin modification and remodelling at the regulatory regions of ER target genes that promotes their expression. A3B expression is associated with poor patient survival in ER+ breast cancer, reinforcing the physiological significance of A3B for ER action.
AU  - Periyasamy,M
AU  - Patel,H
AU  - Lai,C-F
AU  - Nguyen,VTM
AU  - Nevedomskaya,E
AU  - Harrod,A
AU  - Russell,R
AU  - Remenyi,J
AU  - Ochocka,AM
AU  - Thomas,RS
AU  - Fuller-Pace,F
AU  - Gyorffy,B
AU  - Caldas,C
AU  - Navaratnam,N
AU  - Carroll,JS
AU  - Zwart,W
AU  - Coombes,RC
AU  - Magnani,L
AU  - Buluwela,L
AU  - Ali,S
DO  - 10.1016/j.celrep.2015.08.066
EP  - 121
PY  - 2015///
SN  - 2211-1247
SP  - 108
TI  - APOBEC3B mediated cytidine deamination is required for estrogen receptor action in breast cancer
T2  - Cell Reports
UR  - http://dx.doi.org/10.1016/j.celrep.2015.08.066
UR  - http://hdl.handle.net/10044/1/26774
VL  - 13
ER  -
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