Imperial College London


Faculty of MedicineDepartment of Surgery & Cancer

Visiting Reader



+44 (0)20 7594 2822l.castellano Website




ICTEM buildingHammersmith Campus





Within tumours, individual cells often differ genetically while also transitioning between specific cell states linked to disease progression and treatment failure. 

Dr Castellano's group is investigating how non-coding RNAs (ncRNAs) interacting with proteins and DNA control these phenotypes. 

ncRNAs can be short (< 200bp) including the class of microRNAs or longer (> 200bp) and called long non-coding RNAs: both are often dysregulated in cancers, either enhancing or slowing oncogenesis by various mechanisms.  By focusing on the roles of these non-coding RNAs in orchestrating transitions, such as the epithelial-mesenchymal transition that facilitates metastasis, and the differentiation of stem-like tumour cells into differentiated progeny, we hope to elucidate functions of this previously unrecognised layer of regulatory RNAs.

Non-coding RNAs implicated in maintaining these tumour cell states can then offer diagnostic, prognostic and therapeutic potential once their contribution to tumour behaviour is established. Interested candidates with relevant skills and expertise may contact Dr Castellano.



Mato Prado M, Puik JR, Castellano L, et al., 2023, A bile-based microRNA signature for differentiating malignant from benign pancreaticobiliary disease, Experimental Hematology &amp; Oncology, Vol:12, ISSN:2162-3619

Salvato I, Ricciardi L, Dal Col J, et al., 2023, Expression of targets of the RNA-binding protein AUF-1 in human airway epithelium indicates its role in cellular senescence and inflammation, Frontiers in Immunology, Vol:14, ISSN:1664-3224, Pages:1-27

Wang P, Wang Z, Lin Y, et al., 2023, Development of a Novel Pyroptosis-Associated lncRNA Biomarker Signature in Lung Adenocarcinoma, Molecular Biotechnology, ISSN:1073-6085

Shiu PKT, Ilieva M, Holm A, et al., 2023, The Non-Coding RNA Journal Club: Highlights on Recent Papers-12, Non-coding Rna, Vol:9, ISSN:2311-553X

Wang P, Wang Z, Zhu L, et al., 2023, A pyroptosis-related lncRNA signature in bladder cancer, Cancer Medicine, Vol:12, ISSN:2045-7634, Pages:6348-6364

More Publications