DrLeandroCastellano

Faculty of Medicine, Department of Surgery & Cancer

Visiting Reader

Contact

Location

ICTEM buildingHammersmith Campus

Summary

Within tumours, individual cells often differ genetically while also transitioning between specific cell states linked to disease progression and treatment failure.

Dr Castellano's group is investigating how non-coding RNAs (ncRNAs) interacting with proteins and DNA control these phenotypes.

ncRNAs can be short (< 200bp) including the class of microRNAs or longer (> 200bp) and called long non-coding RNAs: both are often dysregulated in cancers, either enhancing or slowing oncogenesis by various mechanisms. By focusing on the roles of these non-coding RNAs in orchestrating transitions, such as the epithelial-mesenchymal transition that facilitates metastasis, and the differentiation of stem-like tumour cells into differentiated progeny, we hope to elucidate functions of this previously unrecognised layer of regulatory RNAs.

Non-coding RNAs implicated in maintaining these tumour cell states can then offer diagnostic, prognostic and therapeutic potential once their contribution to tumour behaviour is established. Interested candidates with relevant skills and expertise may contact Dr Castellano.

Publications

Journals

Salvato I, Ricciardi L, Dal Col J, et al.Salvato I, Ricciardi L, Dal Col J, Nigro A, Giurato G, Memoli D, Sellitto A, Lamparelli EP, Crescenzi MA, Vitale M, Vatrella A, Nucera F, Brun P, Caicci F, Dama P, Stiff T, Castellano L, Idrees S, Johansen MD, Faiz A, Wark PA, Hansbro PM, Adcock IM, Caramori G, Stellato C close, 2023, Expression of targets of the RNA-binding protein AUF-1 in human airway epithelium indicates its role in cellular senescence and inflammation, Frontiers in Immunology, Vol:14, ISSN:1664-3224, Pages:1-27

Wang P, Wang Z, Lin Y, et al.Wang P, Wang Z, Lin Y, Castellano L, Stebbing J, Zhu L, Peng L close, 2023, Development of a Novel Pyroptosis-Associated lncRNA Biomarker Signature in Lung Adenocarcinoma, Molecular Biotechnology, ISSN:1073-6085

Shiu PKT, Ilieva M, Holm A, et al.Shiu PKT, Ilieva M, Holm A, Uchida S, DiStefano JK, Bronisz A, Yang L, Asahi Y, Goel A, Yang L, Nuthanakanti A, Serganov A, Alahari SK, Lin C, Pardini B, Naccarati A, Jin J, Armanios B, Zhong X-B, Sideris N, Bayraktar S, Castellano L, Gerber AP, Lin H, Conn SJ, Sleem DMM, Timmons L close, 2023, The Non-Coding RNA Journal Club: Highlights on Recent Papers-12, Non-coding Rna, Vol:9, ISSN:2311-553X

Wang P, Wang Z, Zhu L, et al.Wang P, Wang Z, Zhu L, Sun Y, Castellano L, Stebbing J, Yu Z, Peng L close, 2023, A pyroptosis-related lncRNA signature in bladder cancer, Cancer Medicine, Vol:12, ISSN:2045-7634, Pages:6348-6364

Correia JS, Miron Barroso S, Hutchings C, et al.Correia JS, Miron Barroso S, Hutchings C, Ottaviani S, Somuncuoğlu B, Castellano L, Porter AE, Krell J, Georgiou TK close, 2023, How does the polymer architecture and position of cationic charges affect cell viability?, Polymer Chemistry, Vol:14, ISSN:1759-9954, Pages:303-317

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