Imperial College London
Alternate

Dr Laure de Preux

Business School

Assistant Professor
 
 
 
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Contact

 

+44 (0)20 7594 9349l.depreux

 
 
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Location

 

486City and Guilds BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Behranwala:2021:10.1080/02699052.2021.1878556,
author = {Behranwala, R and Aojula, N and Hagana, A and Houbby, N and Gallone, LDP},
doi = {10.1080/02699052.2021.1878556},
journal = {Brain Injury},
pages = {444--452},
title = {An economic evaluation for the use of decompressive craniectomy in the treatment of refractory traumatic intracranial hypertension},
url = {http://dx.doi.org/10.1080/02699052.2021.1878556},
volume = {35},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Objectives : The management of intracranial hypertension is a primary concern following traumatic brain injury. Data from recent randomized controlled trials have indicated that decompressive craniectomy results in some improved clinical outcomes compared to medical treatment for patients with refractory intracranial hypertension post-traumatic brain injury (TBI). This economic evaluation aims to assess the cost-effectiveness of decompressive craniectomy as a last-tier intervention for refractory intracranial hypertension from the perspective of the National Health Service (NHS).Methods: A Markov model was used to present the results from an international, multicentre, parallel-group, superiority, randomized trial. A cost-utility analysis was then carried out over a 1-year time horizon, measuring benefits in quality adjusted life years (QALYs) and costs in pound sterling.Results: The cost-utility analysis produced an incremental cost-effectiveness ratio (ICER) of £96,155.67 per QALY. This means that for every additional QALY gained by treating patients with decompressive craniectomy, a cost of £96,155.67 is incurred to the NHS.Conclusions: The ICER calculated is above the National Institute for Health and Care Excellence (NICE) threshold of £30,000 per QALY. This indicates that decompressive craniectomy is not a cost-effective first treatment option for refractory intracranial hypertension and maximum medical management is preferable initially.
AU  - Behranwala,R
AU  - Aojula,N
AU  - Hagana,A
AU  - Houbby,N
AU  - Gallone,LDP
DO  - 10.1080/02699052.2021.1878556
EP  - 452
PY  - 2021///
SN  - 0269-9052
SP  - 444
TI  - An economic evaluation for the use of decompressive craniectomy in the treatment of refractory traumatic intracranial hypertension
T2  - Brain Injury
UR  - http://dx.doi.org/10.1080/02699052.2021.1878556
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000614205600001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://www.tandfonline.com/doi/full/10.1080/02699052.2021.1878556
UR  - http://hdl.handle.net/10044/1/105697
VL  - 35
ER  -
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