Imperial College London


Faculty of MedicineNational Heart & Lung Institute

Professor of Respiratory Cell Biology



+44 (0)20 7594 7895l.donnelly




G227AGuy Scadding BuildingRoyal Brompton Campus





Louise Donnelly is Professor of Respiratory Cell Biology, within the Section of Airway Disease at the NHLI. She obtained her BSc in Biochemistry from the University of Bath and subsequently a PhD in Biochemistry from the University of Cardiff. This was followed by a post-doctoral position in cell signaling at the Royal Postgraduate Medical School (now part of Imperial College London) prior to working at the NHLI.

Since 1995, Professor Donnelly has worked in the field of respiratory cell biology with a particular interest in the cellular profile in inflammatory lung diseases including asthma and COPD. Her research has focussed upon how inflammatory cells are altered in the disease state and the investigation of novel therapeutic strategies. To this end, she has established a number of human primary cell systems to investigate mechanisms of aberrant inflammation. She has published extensively and has presented both nationally and internationally and is an associate editor for the American Journal of Respiratory Cell and Molecular Biology, Respiratory Research and Experimental Lung Research.

Professor Donnelly is currently Director of the Respiratory Science BSc and is involved in respiratory teaching on  the undergraduate MBSS course. In 2009, Professor Donnelly received a Rector's Award for Research Supervision and in 2012 a Rector's Award for Pastoral Care.

Professor Donnelly has been a member of the British Association of Lung Research (BALR) committee for several years and is a past chair of the BALR.  She has served on the British Lung Foundation Scientific Committee and is currently a member of the the European Respiratory Society Fellowship and Awards Working Group.



Belchamber K, Singh R, Batista C, et al., 2019, Defective bacterial phagocytosis is associated with dysfunctional mitochondria in COPD macrophages, European Respiratory Journal, Vol:54, ISSN:0903-1936, Pages:1-14

Barnes PJ, Baker J, Donnelly LE, 2019, Cellular senescence as a mechanism and target in chronic lung diseases, American Journal of Respiratory and Critical Care Medicine, Vol:200, ISSN:1073-449X

Finney LJ, Belchamber KBR, Fenwick PS, et al., 2019, Human rhinovirus impairs the innate immune response to bacteria in alveolar macrophages in chronic obstructive pulmonary disease, American Journal of Respiratory and Critical Care Medicine, Vol:199, ISSN:1073-449X, Pages:1496-1507

Menzies-Gow A, McBrien CN, Baker JR, et al., 2019, Update in asthma/airway inflammation 2018, American Journal of Respiratory and Critical Care Medicine, ISSN:1073-449X

Dunne A, Kawamatawong T, Fenwick P, et al., 2019, Direct inhibitory rffect of the phosphodiesterase-4 inhibitor, roflumilast, on neutrophil migration in COPD, American Journal of Respiratory Cell and Molecular Biology, Vol:60, ISSN:1044-1549, Pages:445-453

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