Imperial College London
Alternate

ProfessorLouiseDonnelly

Faculty of Medicine, National Heart & Lung Institute

Professor of Respiratory Cell Biology
 
 
 
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Contact

 

+44 (0)20 7594 7895l.donnelly

 
 
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Location

 

419Guy Scadding BuildingRoyal Brompton Campus

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Summary

 

Publications

Publication Type
Year
to

256 results found

Russell REK, Culpitt SV, DeMatos C, Donnelly L, Smith M, Wiggins J, Barnes PJet al., 2002, Release and activity of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 by alveolar macrophages from patients with chronic obstructive pulmonary disease, AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, Vol: 26, Pages: 602-609, ISSN: 1044-1549

Journal article

Newton R, Eddleston J, Haddad EB, Hawisa S, Mak J, Lim S, Fox AJ, Donnelly LE, Chung KFet al., 2002, Regulation of kinin receptors in airway epithelial cells by inflammatory cytokines and dexamethasone, EUROPEAN JOURNAL OF PHARMACOLOGY, Vol: 441, Pages: 193-202, ISSN: 0014-2999

Journal article

Traves SL, Smith SJ, Barnes PJ, Donnelly LEet al., 2002, Increased migration of monocytes from COPD patients towards GROα is not mediated by an increase in CXCR<sub>2</sub> receptor expression, BRITISH JOURNAL OF PHARMACOLOGY, Vol: 135, ISSN: 0007-1188

Journal article

Donnelly LE, Barnes PJ, 2002, Expression and regulation of inducible nitric oxide synthase from human primary airway epithelial cells, AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, Vol: 26, Pages: 144-151, ISSN: 1044-1549

Journal article

Balint B, Kharitonov SA, Hanazawa T, Donnelly LE, Shah PL, Hodson ME, Barnes PJet al., 2001, Increased nitrotyrosine in exhaled breath condensate in cystic fibrosis, EUROPEAN RESPIRATORY JOURNAL, Vol: 17, Pages: 1201-1207, ISSN: 0903-1936

Journal article

Balint B, Donnelly LE, Hanazawa T, Kharitonov SA, Barnes PJet al., 2001, Increased nitric oxide metabolites in exhaled breath condensate after exposure to tobacco smoke, THORAX, Vol: 56, Pages: 456-461, ISSN: 0040-6376

Journal article

Finney PA, Donnelly LE, Belvisi MG, Chuang TT, Birrell M, Harris A, Mak JCW, Scorer C, Barnes PJ, Adcock IM, Giembycz MAet al., 2001, Chronic systemic administration of salmeterol to rats promotes pulmonary β<sub>2</sub>-adrenoceptor desensitization and down-regulation of G<sub>sα</sub>, BRITISH JOURNAL OF PHARMACOLOGY, Vol: 132, Pages: 1261-1270, ISSN: 0007-1188

Journal article

Corradi M, Montuschi P, Donnelly LE, Pesci A, Kharitonov SA, Barnes PJet al., 2001, Increased nitrosothiols in exhaled breath condensate in inflammatory airway diseases, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 163, Pages: 854-858, ISSN: 1073-449X

Journal article

Donnelly LE, Barnes PJ, 2001, Expression of heme oxygenase in human airway epithelial cells, AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, Vol: 24, Pages: 295-303, ISSN: 1044-1549

Journal article

, 2001, Administration of Resveratrol to Treat Inflammatory Respiratory Disorders, 09/694, 108

Patent

Horvath I, MacNee W, Kelly FJ, Dekhuijzen PN, Phillips M, Doring G, Choi AM, Yamaya M, Bach FH, Willis D, Donnelly LE, Chung KF, Barnes PJet al., 2001, "Haemoxygenase-1 induction and exhaled markers of oxidative stress in lung diseases", summary of the ERS Research Seminar in Budapest, Hungary, September, 1999, Eur Respir J, Vol: 18, Pages: 420-430, ISSN: 0903-1936

In recent years, there has been increasing interest in noninvasive monitoring of airway inflammation and oxidative stress. Several volatile and nonvolatile substances can be measured in exhaled breath and have been suggested as potential biomarkers of these events. Exhaled gases, including carbon monoxide (CO), alkanes (ethane, pentane), and substances measured in breath condensate, such as hydrogen peroxide (H2O2) and isoprostanes were all suggested as potential markers of oxidative stress in the lung. A European Respiratory Society (ERS) International Research Seminar entitled "Haemoxygenase-1 induction and exhaled markers of oxidative stress in lung diseases" was organized by the Airway Regulation and Provocation Group of the Clinical Allergy and Immunology Assembly in Budapest, Hungary in September, 1999 to integrate the latest knowledge on these issues and accelerate further improvement in this area. During this 2-day event several issues were raised about: the use and standardization of measurements in exhaled breath; problems of measuring expired H2O2 and other mediators in breath condensate; role and regulation of haemoxygenase (HO)-1 in the lung; and conditions and factors influencing exhaled CO. This report is a summary of the main presentations at the seminar, together with the current areas of research in this rapidly expanding field.

Journal article

Donnelly LE, 2001, Human Airway Inflammation: Sampling techniques and analytical protocols, ISBN: 9780896039230

Book

Donnelly LE, 2001, Airway Epithelial Cells (Primaries vs Cell lines), Pages: 127-136, ISBN: 9780896039230

Book chapter

Finney PA, Belvisi MG, Donnelly LE, Chuang TT, Mak JCW, Scorer C, Barnes PJ, Adcock IM, Giembycz MAet al., 2000, Albuterol-induced downregulation of Gsα accounts for pulmonary β<sub>2</sub>-adrenoceptor desensitization in vivo, JOURNAL OF CLINICAL INVESTIGATION, Vol: 106, Pages: 125-135, ISSN: 0021-9738

Journal article

Nightingale JA, Maggs R, Cullinan P, Donnelly LE, Rogers DF, Kinnersley R, Chung KF, Barnes PJ, Ashmore M, Newman-Taylor Aet al., 2000, Airway inflammation after controlled exposure to diesel exhaust particulates, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 162, Pages: 161-166, ISSN: 1073-449X

Journal article

Horvath I, Donnelly LE, Kiss A, Kharitonov SA, Lim A, Chung KF, Barnes PJet al., 1999, Combined use of exhaled hydrogen peroxide and nitric oxide in monitoring asthma, Pneumologie, Vol: 53, ISSN: 0934-8387

Journal article

Patel HJ, Belvisi MG, Donnelly LE, Yacoub MH, Chung KF, Mitchell JAet al., 1999, Constitutive expressions of type INOS in human airway smooth muscle cells: evidence for an antiproliferative role, FASEB JOURNAL, Vol: 13, Pages: 1810-1816, ISSN: 0892-6638

Journal article

Donnelly LE, Lim S, Chung KF, Barnes PJet al., 1999, Expression of heme-oxygenase in human airway primary epithelial cells., Publisher: AMER LUNG ASSOC, Pages: A218-A218, ISSN: 1073-449X

Conference paper

Patel HJ, Belvisi MG, Donnelly LE, Yacoub MH, Chung KF, Mitchell JAet al., 1999, Constitutive expression of nNOS in human cultured airway smooth muscle cells: Evidence for an anti-proliferative role., Publisher: AMER LUNG ASSOC, Pages: A531-A531, ISSN: 1073-449X

Conference paper

Mattos WL, Russell R, Donnelly LE, Jatakanon A, Lim S, Barnes PJet al., 1999, Sputum gelatinases do not change after allergen challenge, Publisher: AMER LUNG ASSOC, Pages: A324-A324, ISSN: 1073-449X

Conference paper

Lim S, Donnelly LE, Chung KF, Barnes PJet al., 1999, Human bronchial epithelial cells do not express the antiinflammatory cytokine I-10., Publisher: AMER LUNG ASSOC, Pages: A103-A103, ISSN: 1073-449X

Conference paper

Russell REK, Donnelly LE, Wiggins J, Barnes PJet al., 1999, The St George's Respiratory Questionnaire in the assessment of early chronic obstructive pulmonary disease, Publisher: AMER LUNG ASSOC, Pages: A460-A460, ISSN: 1073-449X

Conference paper

Donnelly LE, Adcock IM, Lim S, Chung KF, Barnes PJet al., 1999, Effect of glucocorticosteroids on inducible nitric oxide synthase expression in human airway primary epithelial cells., Publisher: AMER LUNG ASSOC, Pages: A446-A446, ISSN: 1073-449X

Conference paper

Eddleston J, Fox AJ, Lim S, Donnelly LE, Newton R, Haddad EB, Chung KFet al., 1999, Expression of the bradykinin B1 and B2 receptors in human airway epithelial cells., Publisher: AMER LUNG ASSOC, Pages: A180-A180, ISSN: 1073-449X

Conference paper

Russell REK, Donnelly LE, Culpitt SJ, Wiggins J, Barnes PJet al., 1999, Matrix metalloproteinases in the induced sputum of healthy smokers with early chronic obstructive pulmonary disease, Publisher: AMER LUNG ASSOC, Pages: A800-A800, ISSN: 1073-449X

Conference paper

Finney PA, Belvisi MG, Barnes PJ, Donnelly LE, Adcock IM, Giembycz MAet al., 1999, <i>In vivo</i> heterologous desensitisation of pulmonary β<sub>2</sub>-adrenoceptors in Sprague-Dawley rats after chronic treatment with salmeterol., Publisher: AMER LUNG ASSOC, Pages: A396-A396, ISSN: 1073-449X

Conference paper

Corradi M, Montuschi P, Donnelly LE, Hodson ME, Kharitonov SA, Barnes PJet al., 1999, Nitrosothiols and nitrite in exhaled breath condensate of patients with cystic fibrosis., Publisher: AMER LUNG ASSOC, Pages: A682-A682, ISSN: 1073-449X

Conference paper

Horváth I, Donnelly LE, Kiss A, Kharitonov SA, Lim S, Chung KF, Barnes PJet al., 1998, Combined use of exhaled hydrogen peroxide and nitric oxide in monitoring asthma, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 158, Pages: 1042-1046, ISSN: 1073-449X

Journal article

Newton R, Hart LA, Stevens DA, Bergmann M, Donnelly LE, Adcock IM, Barnes PJet al., 1998, Effect of dexamethasone on interleukin-1β(IL-1β)-induced nuclear factor-κB (NF-κB) and κB-dependent transcription in epithelial cells, EUROPEAN JOURNAL OF BIOCHEMISTRY, Vol: 254, Pages: 81-89, ISSN: 0014-2956

Journal article

Kaba R, Coppen SR, Dupont E, Skepper JN, Elneil S, Haw M, Pepper J, Yacoub M, Rothery S, Severs NJet al., 1998, Raised levels of exhaled carbon monoxide are associated with an increased expression of heme oxygenase-1 in airway macrophages in asthma: a new marker of oxidative stress, [Thorax, Vol: 53, Pages: 668-672

Journal article

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