DrLeanneFelkin

Faculty of Medicine, National Heart & Lung Institute

Healthcare Senior Teaching Fellow

Contact

+44 (0)20 7594 8582l.felkin

Location

G218Guy Scadding BuildingRoyal Brompton Campus

Summary

I am a Senior Teaching Fellow on the MSc Cardiovascular and Respiratory Healthcare programme hosted by the National Heart and Lung Institute (NHLI). Together with the Course Director and Course Administrator, I plan and organise all aspects of the programme and I work with our Module Leads and lecturers to develop and deliver innovative teaching and assessment methods. I am Module Lead for the Research Project module and a personal tutor for postgraduate students.

I studied Genetics and Zoology as an undergraduate at Swansea University before spending 2 years in industry developing a DNA based security system. In 2000, I moved to NHLI where I managed the departmental real-time PCR facility and began my PhD research supervised by Prof Sir Magdi Yacoub and Dr Paul Barton. My PhD investigated the role of cardiac extracellular matrix - the non-cellular portion of the heart, often likened to the scaffolding of the tissue - in the development of heart failure and recovery from heart failure using left ventricular assist devices (a type of artificial heart).

Following the award of my PhD, I continued my research into the molecular mechanisms of cardiac recovery at NHLI before taking up a teaching role in 2019.

I am currently working towards my Master's degree in University Learning and Teaching (ULT, Imperial College London) after completing the PGDip and PGCert in ULT.

Outside of work, I am a governor at a primary school with responsibility for safeguarding, curriculum, assessment and standards, and pupil voice. I am interested in the promotion of science as a career for young women and have previously work with the WISE campaign (Women into Science and Engineering) giving TV and newspaper interviews (including the Sunday Times and Evening Standard) and was profiled in ‘One Hundred Faces of Modern Science’, part of Science Year (2001), a nationwide initiative to promote science in schools.

Publications

Journals

Reichart D, Lindberg EL, Maatz H, et al.Reichart D, Lindberg EL, Maatz H, Miranda AMA, Viveiros A, Shvetsov N, Gaertner A, Nadelmann ER, Lee M, Kanemaru K, Ruiz-Orera J, Strohmenger V, DeLaughter DM, Patone G, Zhang H, Woehler A, Lippert C, Kim Y, Adami E, Gorham JM, Barnett SN, Brown K, Buchan RJ, Chowdhury RA, Constantinou C, Cranley J, Felkin LE, Fox H, Ghauri A, Gummert J, Kanda M, Li R, Mach L, McDonough B, Samari S, Shahriaran F, Yapp C, Stanasiuk C, Theotokis P, Theis FJ, van den Bogaerdt A, Wakimoto H, Ware JS, Worth CL, Barton PJR, Lee Y-A, Teichmann SA, Milting H, Noseda M, Oudit GY, Heinig M, Seidman JG, Hubner N, Seidman CE close, 2022, Pathogenic variants damage cell composition and single-cell transcription in cardiomyopathies, Science, Vol:377, ISSN:0036-8075, Pages:1-13

Clerk A, Meijles DN, Hardyman MA, et al.Clerk A, Meijles DN, Hardyman MA, Fuller SJ, Chothani SP, Cull JJ, Cooper STE, Alharbi HO, Vanezis K, Felkin LE, Markou T, Leonard SJ, Shaw SW, Rackham OJL, Cook SA, Glennon PE, Sheppard MN, Sembrat JC, Rojas M, McTiernan CF, Barton PJ, Sugden PH close, 2022, Cardiomyocyte BRAF and type 1 RAF inhibitors promote cardiomyocyte and cardiac hypertrophy in mice in vivo, Biochemical Journal, Vol:479, ISSN:0264-6021, Pages:401-424

Widjaja AA, Dong J, Adami E, et al.Widjaja AA, Dong J, Adami E, Viswanathan S, Ng B, Pakkiri LS, Chothani SP, Singh BK, Lim WW, Zhou J, Shekeran SG, Tan J, Lim SY, Goh J, Wang M, Holgate R, Hearn A, Felkin LE, Yen PM, Dear JW, Drum CL, Schafer S, Cook SA close, 2021, Redefining IL11 as a regeneration-limiting hepatotoxin and therapeutic target in acetaminophen-induced liver injury, Science Translational Medicine, Vol:13, ISSN:1946-6234

Mazzarotto F, Tayal U, Buchan RJ, et al.Mazzarotto F, Tayal U, Buchan RJ, Midwinter W, Wilk A, Whiffin N, Govind R, Mazaika E, de Marvao A, Dawes T, Felkin LE, Ahmad M, Theotokis PI, Edwards E, Ing AI, Thomson KL, Chan LLH, Sim D, Baksi AJ, Pantazis A, Roberts AM, Watkins H, Funke B, O'Regan D, Olivotto I, Barton PJR, Prasad SK, Cook SA, Ware JS, Walsh R close, 2020, Re-evaluating the genetic contribution of monogenic dilated cardiomyopathy, Circulation, Vol:141, ISSN:0009-7322, Pages:387-398

Conference

Walsh R, Mazzarotto F, Whiffin N, et al.Walsh R, Mazzarotto F, Whiffin N, Buchan R, Li N, Felkin L, Thomson KL, Watkins H, Barton PJR, Olivotto I, Cook SA, Bezzina CR, Ware JS close, 2019, Quantitative approaches to variant classification increase the yield and precision of genetic testing in Mendelian diseases, 52nd Conference of the European-Society-of-Human-Genetics (ESHG), NATURE PUBLISHING GROUP, Pages:1720-1720, ISSN:1018-4813

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