Imperial College London


Faculty of MedicineNational Heart & Lung Institute

Honorary Senior Research Fellow



+44 (0)20 7352 8121 ext 2938l.fleming




Department of Respiratory PaediaRoyal BromptonRoyal Brompton Campus





Dr Louise Fleming is an Honorary Senior Fellow in Respiratory Paediatrics and part of the Paediatric Severe Asthma Research Group. She is Deputy Senior Tutor for Phase 2 MBBS (Year 4) and a Consultant Respiratory Paediatrician West London Children's Hospital (part of Imperial Healthcare NHS Trust) and the Royal Brompton hospital. 

Dr Louise Fleming completed her undergraduate degree in medicine at the University of Manchester before moving to London for postgraduate training in Paediatrics. This included an 18-month VSO/RCPCH Fellowship in The Gambia.

Dr Fleming undertook postgraduate research at NHLI and the Royal Brompton Hospital, funded by the British Lung Foundation, under the supervision of Professor Andrew Bush and Dr Nicola Wilson. She carried out a randomised controlled trial investigating the use of inflammatory markers to guide management in children with severe asthma.

Dr Fleming’s research interests include characterizing problematic severe asthma; monitoring asthma including adherence and use of biomarkers; identification of novel therapeutic targets and non-pharmacological management of asthma including behaviour change. Current work includes the use of novel adherence monitoring devices, understanding determinants of poor adherence in the individual and targeting interventions accordingly. Clinically she looks after children with a wide range of respiratory problems. Interests include the systematic multi-disciplinary assessment of children with problematic severe asthma and dysfunctional breathing. She is a member of the difficult asthma team at the Royal Brompton where she has developed the difficult asthma protocol and the National Registry for children with difficult asthma.

Dr Fleming  is a member of the GINA Science Committee, Asthma UK Health Professionals Council (past chair), BPRS Executive Committee and RSM Paediatrics and Child Health Council (past president). She has previously served on the BTS Specialist Advisory Group for Severe Asthma and the BTS/SIGN clinical guidelines group. She is an Associate Editor (respiratory) for Archives of Disease in Childhood. She is a strong advocate for children with asthma and improving care to deliver better outcomes. In order to achieve this, she is a member of a number of networks including the London Asthma Leadership and Implementation Group, London Paediatric Severe Asthma Group (Chair), Children and Young People Asthma Oversight Group and North West London Paediatric asthma network.



Kallis C, Morgan A, Fleming L, et al., 2023, Prevalence of poorly controlled asthma and factors associated with specialist referral in those with poorly controlled asthma in a paediatric asthma population, Journal of Asthma and Allergy, ISSN:1178-6965

Levy ML, Bateman ED, Allan K, et al., 2023, Global access and patient safety in the transition to environmentally friendly respiratory inhalers: the Global Initiative for Asthma perspective., Lancet, Vol:402, Pages:1012-1016

Fleming L, Hine J, Bush A, et al., 2023, Patient financial incentives to improve asthma management: a systematic review, Bmj Open, Vol:13, ISSN:2044-6055, Pages:1-9

Abdel-Aziz MI, Thorsen J, Hashimoto S, et al., 2023, Oropharyngeal Microbiota Clusters in Children with Asthma or Wheeze Associate with Allergy, Blood Transcriptomic Immune Pathways, and Exacerbation Risk., Am J Respir Crit Care Med, Vol:208, Pages:142-154

Brandsma J, Schofield JPR, Yang X, et al., 2023, Stratification of asthma by lipidomic profiling of induced sputum supernatant, Journal of Allergy and Clinical Immunology, Vol:152, ISSN:0091-6749, Pages:117-125

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