Imperial College London
Portrait Picture

DrLouiseFleming

Faculty of Medicine, National Heart & Lung Institute

Honorary Senior Research Fellow
 
 
 
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Contact

 

+44 (0)20 7352 8121 ext 2938l.fleming

 
 
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Location

 

Department of Respiratory PaediaRoyal BromptonRoyal Brompton Campus

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Summary

 

Publications

Publication Type
Year
to

298 results found

Hall P, Bracken M, Winch D, Nagakumar P, Bush A, Saglani S, Fleming Let al., 2014, SMARTINHALERS - A NEW APPROACH TO ASSESSING ADHERENCE IN DIFFICULT ASTHMA, Meeting of the British-Thoracic-Society, Publisher: BMJ PUBLISHING GROUP, Pages: A182-A182, ISSN: 0040-6376

Conference paper

Robson K, Nagakumar P, Collins N, Davies JC, Fleming L, Balfour-Lynn I, Rosenthal M, Hogg C, Jochmann A, Bush A, Saglani Set al., 2014, SAFETY, FEASIBILITY AND QUALITY OF SPUTUM INDUCTION IN PRESCHOOL CHILDREN WITH OBSTRUCTIVE AIRWAYS DISEASE, Meeting of the British-Thoracic-Society, Publisher: BMJ PUBLISHING GROUP, Pages: A123-A123, ISSN: 0040-6376

Conference paper

Nagakumar P, Hall P, Bracken M, Saglani S, Bush A, Fleming Let al., 2014, IS PRESCRIPTION UPTAKE AND MEDICATION ADHERENCE RATING SCALE (MARS) A USEFUL TOOL IN ASSESSING ASTHMA CONTROL IN CHILDREN WITH PROBLEMATIC SEVERE ASTHMA (PSA)?, Meeting of the British-Thoracic-Society, Publisher: BMJ PUBLISHING GROUP, Pages: A98-A98, ISSN: 0040-6376

Conference paper

Ahmad FA, Irving SI, Bush AB, Fleming LF, Saglani SSet al., 2014, MULTIPLE BREATH WASHOUTS IN CHILDREN CAN BE SIGNIFICANTLY SHORTENED WITHOUT COMPROMISING MEASUREMENT QUALITY, Meeting of the British-Thoracic-Society, Publisher: BMJ PUBLISHING GROUP, Pages: A166-A167, ISSN: 0040-6376

Conference paper

Brinkman P, Hashimoto S, Fleming LJ, Hedlin G, Knobel H, Vink TJ, Rattray N, Santonico M, Pennazza G, D'Amico A, Montuschi P, Fowler S, Cortield J, Rowe A, Singer PF, Frey U, Bisgaard H, Bush A, Wagers SS, Chung KF, Shaw DE, Pandis I, Compton C, Siebold W, Barisal AT, Roberts G, van Aalderen WM, Sterk PJet al., 2014, Unbiased clustering of children with asthma or pre-school wheeze using the U-BIOPRED electronic nose platform, Publisher: EUROPEAN RESPIRATORY SOC JOURNALS LTD, ISSN: 0903-1936

Conference paper

Blok F, Irving S, Bush A, Saglani S, Fleming L, Tupker Fet al., 2014, Positive relationship between offline exhaled nitric oxide and lung clearance index in pre-school wheezers, Publisher: EUROPEAN RESPIRATORY SOC JOURNALS LTD, ISSN: 0903-1936

Conference paper

Sousa AR, Pandis I, Xian Y, Hoda U, Rowe A, Corfield J, Jeyasingham E, Bansal A, Seibold W, Wagener A, Bakke P, Roberts G, Singer F, Frey U, Ildiko H, Polosa R, Krug N, Middelveld R, Dahlen S-E, Musial J, Gibeon D, Fleming L, Fowler S, Pahus L, Shaw D, Howarth P, Myles D, Compton C, Higenbottam T, Montuschi P, Vestbo J, Nihlen U, Sandstrom T, Wagers S, Djukanovic R, Bel E, Sterk P, Chung Fet al., 2014, Characteristics of the adult corticosteroid-dependent severe asthma in UBIOPRED consortium, Publisher: EUROPEAN RESPIRATORY SOC JOURNALS LTD, ISSN: 0903-1936

Conference paper

Tupker F, Blok F, Irving S, Bush A, Fleming L, Saglani Set al., 2014, Non-invasive markers of airway eosinophilic inflammation in pre-school children, Publisher: EUROPEAN RESPIRATORY SOC JOURNALS LTD, ISSN: 0903-1936

Conference paper

Fleming L, Sousa A, Murray C, Hashimoto S, Hedlin G, Corfield J, Anthony R, Singer F, Frey U, Bisgaard H, Bush A, Wagers S, Chung KF, Shaw D, Fowler S, Pandis I, Compton C, Seibold W, Bansal A, Sterk P, Roberts Get al., 2014, U-BIOPRED: Clinical characteristics of children with severe asthma (SA) and severe pre-school wheeze (SPSW), Publisher: EUROPEAN RESPIRATORY SOC JOURNALS LTD, ISSN: 0903-1936

Conference paper

Brugha RE, Mustaq N, Round T, Gadhvi DH, Dundas I, Gaillard E, Koh L, Fleming L, Lewis D, Sanak M, Wood HE, Barratt B, Mudway IS, Kelly F, Griffiths CJ, Gigg Jet al., 2014, Carbon in airway macrophages from children with asthma, Thorax, Vol: 69, Pages: 654-659, ISSN: 0040-6376

Background Airway macrophage (AM) phagocytosis is impaired in severe asthma. Prostaglandin (PG) E2 and D2 are increased in severe asthma and suppress AM phagocytic function in vitro. In this study, we sought evidence for PG-mediated impairment of phagocytosis of inhalable carbonaceous particulate matter (PM) by AM in children with severe asthma compared with mild asthmatics and healthy controls.Methods AM were obtained from children with asthma and healthy controls using induced sputum. AM carbon area (μm2) was assessed by image analysis. In a subgroup of asthmatics, urinary PGE2 and PGD2 metabolites were measured by high-performance liquid chromatography, and PM exposure at the home address was modelled. Phagocytosis of PM by human monocyte-derived macrophages and rat AM was assessed in vitro by image analysis.Results AM carbon was 51% lower in children with moderate-to-severe asthma (n=36) compared with mild asthmatics (n=12, p<0.01) and healthy controls (n=47, p<0.01). There was no association between modelled PM exposure and AM carbon in 33 asthmatics who had a urine sample, but there was an inverse association between AM carbon and urinary metabolites of PGE2 and D2 (n=33, rs=−0.40, p<0.05, and rs=−0.44, p<0.01). PGE2 10−6 M, but not PGD2 10−6 M, suppressed phagocytosis of PM10 by human macrophages in vitro (p<0.05 vs control). PGE2 10−6 M also suppressed phagocytosis of PM10 by rat AM in vitro (p<0.01 vs control).Conclusions Phagocytosis of inhaled carbonaceous PM by AMs is impaired in severe asthma. PGE2 may contribute to impaired AM phagocytic function in severe asthma.

Journal article

Hekking P-P, Wagener AH, Sousa AR, Fowler SJ, Bakke P, Frey U, Krug N, Hashimoto S, Woodcock A, Chanez P, Montuschi P, Bisgaard H, Corfield J, Howarth PH, Djukanovic R, Chung K, Fleming L, Riley J, Jeyasingham E, Fichtner K, Rowe A, Roberts G, Singer F, Geiser T, Horvath I, Polosa R, Vissing N, Dahlen B, Musial J, Murray C, Myles D, Compton C, Higenbottam TW, Vestbo J, Pahus L, Larsson L, Sandstrom T, Shaw D, Wagers SS, Sterk PJ, Bansal AT, Bel Eet al., 2014, Prevalence And Phenotypic Characteristics Of Severe Adult-Onset Asthma In The U-Biopred Cohort, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 189, ISSN: 1073-449X

Journal article

Chung KF, Gibeon D, Sousa AR, Corfield J, Shaw DE, Fowler SJ, Fleming LJ, Riley J, Jeyasingham E, Rowe A, Fichtner K, Roberts G, Bakke P, Von Garnier C, Horvath I, Riccardo P, Krug N, Dahlen B, Musial J, Pahus L, Myles D, Compton C, Higenbottam TW, Montuschi P, Larsson L, Sandstrom T, Wagers SS, Howarth PH, Bel E, Bansal AT, Djukanovic R, Sterk PJet al., 2014, Severe Asthma Patients On Oral Corticosteroid Therapy As A Distinct Phenotype: The European U-Biopred Cohort, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 189, ISSN: 1073-449X

Journal article

Hopkinson N, Wallis C, Higgins B, Gaduzo S, Sherrington R, Keilty Set al., 2013, CIGARETTE PACKAGING Children must be protected from the tobacco industry's marketing tactics, BMJ-BRITISH MEDICAL JOURNAL, Vol: 347, ISSN: 1756-1833

Journal article

Koo MK, Bossley CB, Carlton AC, Bush AB, Saglani SS, Fleming LFet al., 2013, REAL-LIFE EXPERIENCE OF OMALIZUMAB IN CHILDREN WITH SEVERE ASTHMA, Winter Meeting of the British-Thoracic-Society, Publisher: BMJ PUBLISHING GROUP, Pages: A115-A115, ISSN: 0040-6376

Conference paper

Gibeon D, Wagener AH, Yang X, Sousa AR, Corfield J, Shaw DE, Fowler S, Fleming LJ, Riley J, Jeyasingham E, Rowe A, Fichtner K, Roberts G, Bakke P, Singer F, Geiser T, Frey U, Horvarth I, Polosa R, Bonnelykke K, Krug N, Middelveld R, Dahlen S-E, Dahlen B, Hedlin G, Hashimoto S, Nordlund B, Musial J, Woodcock A, Murray CS, Pahus L, Chanez P, Myles D, Compton C, Higenbottam TW, Montuschi P, Vestbo J, Larsson L, Sandstrom T, Bisgaard H, Wagers SS, Howarth PH, Bel EH, Djukanovic R, Sterk PJ, Chung KFet al., 2013, U-BIOPRED asthma cohort: Inflammatory markers and corticosteroid use, EUROPEAN RESPIRATORY JOURNAL, Vol: 42, ISSN: 0903-1936

Journal article

Macleod K, Irving S, Adams A, Gupta A, Bossley C, Bush A, Fleming Let al., 2013, Lung function measured by multiple breath inert gas washout in children with severe asthma (SA) before and after intramuscular triamcinolone, EUROPEAN RESPIRATORY JOURNAL, Vol: 42, ISSN: 0903-1936

Journal article

Wagener A, Gibeon D, Yang X, Sousa A, Corfield J, Shaw D, Fowler S, Fleming L, Riley J, Jeyasingham L, Rowe A, Fichtner K, Roberts G, Bakke P, Singer F, Geiser T, Frey U, Horvarth I, Polosa R, Bonnelykke K, Krug N, Middelveld R, Dahlen S-E, Dahlen B, Hedlin G, Hashimoto S, Nordlund B, Musial J, Woodcock A, Murray C, Pahus L, Chanez P, Myles D, Compton C, Higenbottam TW, Montuschi P, Vestbo J, Larsson L, Sandstrom T, Bisgaard H, Wagers SS, Howarth PH, Bel EH, Djukanovic R, Chung F, Sterk Pet al., 2013, Associated factors with persistent airflow limitation in asthma in U-BIOPRED, EUROPEAN RESPIRATORY JOURNAL, Vol: 42, ISSN: 0903-1936

Journal article

Fleming L, Tsartsali L, Wilson N, Regamey N, Bush Aet al., 2013, Longitudinal Relationship between Sputum Eosinophils and Exhaled Nitric Oxide in Children with Asthma, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 188, Pages: 400-402, ISSN: 1073-449X

Journal article

Ullmann N, Bossley CJ, Fleming L, Silvestri M, Bush A, Saglani Set al., 2013, Blood eosinophil counts rarely reflect airway eosinophilia in children with severe asthma, ALLERGY, Vol: 68, Pages: 402-406, ISSN: 0105-4538

Journal article

Chung K, Corfield J, Jeyasingham E, Wille DR, Rowe A, Fichtner K, Wagener AH, Krug N, Hashimoto S, Bush A, Chanez P, Knox AJ, Montuschi P, Vestbo J, Bisgaard H, Roberts G, Singer F, Frey U, Horvath I, Polosa R, Bonnelykke K, Dahlen B, Nordlund B, Musial J, Gideon D, Woodcock A, Fowler SJ, Shaw DE, Pahus L, Yang X, Myles D, Larson L, Sandstrom T, Hedlin G, Bakke PS, Geiser T, Middelveld R, Dahlen SE, Fleming LJ, Murray CS, Compton CH, Higgenbottam TW, Wagers SS, Howarth PH, Bell ED, Djukanovic R, Sterk PJ, Sousa ARet al., 2013, U-Biopred Adult And Paediatric Cohorts: A Novel Approach To Characterise Severe Asthma, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 187, ISSN: 1073-449X

Journal article

Fleming L, Bush A, 2012, Use of sputum eosinophil counts to guide management in children with severe asthma, THORAX, Vol: 67, Pages: 1015-U113, ISSN: 0040-6376

Journal article

Castanhinha S, Gupta A, Maglione M, Koo S, Bossley C, Fleming L, Bush A, Saglani Set al., 2012, Fungal sensitisation in children with severe therapy resistant asthma, Publisher: EUROPEAN RESPIRATORY SOC JOURNALS LTD, ISSN: 0903-1936

Conference paper

Koo S, Gupta A, Fainardi V, Bossley C, Bush A, Saglani S, Fleming Let al., 2012, Ethnic variation in response to intramuscular triamcinolone in children with severe therapy resistant asthma, Publisher: EUROPEAN RESPIRATORY SOC JOURNALS LTD, ISSN: 0903-1936

Conference paper

Bush A, Fleming L, 2012, 2012 and never been KISSed: we need to improve the care of children with asthma, PRIMARY CARE RESPIRATORY JOURNAL, Vol: 21, Pages: 242-244, ISSN: 1471-4418

Journal article

Fleming L, Tsartsali L, Wilson N, Regamey N, Bush Aet al., 2012, Sputum inflammatory phenotypes are not stable in children with asthma, THORAX, Vol: 67, Pages: 675-681, ISSN: 0040-6376

Journal article

Sharples J, Gupta A, Fleming L, Bossley CJ, Bracken-King M, Hall P, Hayward A, Puckey M, Balfour-Lynn IM, Rosenthal M, Bush A, Saglani Set al., 2012, Long-term effectiveness of a staged assessment for paediatric problematic severe asthma, EUROPEAN RESPIRATORY JOURNAL, Vol: 40, Pages: 264-267, ISSN: 0903-1936

Journal article

Bossley CJ, Fleming L, Gupta A, Regamey N, Frith J, Oates T, Tsartsali L, Lloyd CM, Bush A, Saglani Set al., 2012, Pediatric severe asthma is characterized by eosinophilia and remodeling without T<sub>H</sub>2 cytokines, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Vol: 129, Pages: 974-U469, ISSN: 0091-6749

Journal article

Fleming L, Wilson N, Regamey N, Bush Aet al., 2012, Use of sputum eosinophil counts to guide management in children with severe asthma, THORAX, Vol: 67, Pages: 193-198, ISSN: 0040-6376

Journal article

Castanhinha S, Gupta A, Maglione M, Koo S, Bossley C, Fleming L, Bush A, Saglani Set al., 2011, FUNGAL SENSITISATION IN CHILDREN WITH SEVERE THERAPY RESISTANT ASTHMA, Winter Meeting of the British-Thoracic-Society, Publisher: B M J PUBLISHING GROUP, Pages: A39-A40, ISSN: 0040-6376

Conference paper

Vosicka K, di Pasquale J, Gore R, Fleming L, Warner JO, Habibi P, Boyle RJet al., 2011, Effects of Temperature-controlled laminar airflow on sleep quality in allergic rhinitis: a pilot study, Annual Meeting of the British-Society-for-Allergy-and-Clinical-Immunology (BSACI), Publisher: WILEY-BLACKWELL, Pages: 1847-1847, ISSN: 0954-7894

Conference paper

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