Imperial College London
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DrLouiseFleming

Faculty of Medicine, National Heart & Lung Institute

Honorary Senior Research Fellow
 
 
 
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Contact

 

+44 (0)20 7352 8121 ext 2938l.fleming

 
 
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Location

 

Department of Respiratory PaediaRoyal BromptonRoyal Brompton Campus

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Summary

 

Publications

Citation

BibTex format

@article{Saglani:2019,
author = {Saglani, S and Fleming, L and Sonnappa, S and Bush, A},
journal = {Lancet Child and Adolescent Health},
title = {Recent advances in the aetiology, management and prevention of acute asthma attacks},
url = {http://hdl.handle.net/10044/1/67158},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Acute attacks of wheeze or asthma remain among the most common reasons for paediatric hospital attendance and rates of severe attacks in the UK are among the highest in Europe. Although most attacks are precipitated by infection, there are critical differences in the underlying pathophysiology between preschool and school-aged children. Allergen sensitisation, airway eosinophilia and type 2 inflammation are predominant in older children, while phenotypes in younger children are variable, often including non-atopic, neutrophilic infection driven episodes. Currently, a universal approach is adopted towards management in all ages, but there is a need to make objective assessments of airway function, inflammation and infection both during the attack and in disease stability to identify “treatable traits” and target therapy if we are to improve outcomes. An assessment of risk factors that led to the attack and early, focussed follow-up is essential to ensure attacks are a “never event”.
AU  - Saglani,S
AU  - Fleming,L
AU  - Sonnappa,S
AU  - Bush,A
PY  - 2019///
SN  - 2352-4642
TI  - Recent advances in the aetiology, management and prevention of acute asthma attacks
T2  - Lancet Child and Adolescent Health
UR  - http://hdl.handle.net/10044/1/67158
ER  -
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